Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression.

myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) characterized by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse the epigenetic repression, such as 5-azacytidine (5-AZA), induces hematologic improvement in half of the patients treated.

Although the underlying mechanisms of therapeutic efficacy is not yet clear, the induction of endogenous retroelements (eres) has hypothesised.Using RNA sequencing (RNA-seq), we compared the transcriptional Eres in bone marrow HSCs of a new cohort of MDS and chronic myelomonocytic leukemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and patients with AML.

We further examined the ERE transcription using a comprehensive explanation ERE partially-overlapping transcripts expressed in HSCs, produced here by de novo assembly and supported by transcripts of full-length RNA-seq.Consistent with previous reports, we found that treatment with 5- AZA increased representation of ERE-derived RNA-seq reads in the transcriptome. However, the increase is comparable between treatment response and failure.

Extended view HSC transcription diversity offered by de novo assembly transcripts against Eres 5-AZA-responsive as a determinant of treatment outcome. In contrast, pre-treatment revealed expression and alternative splicing gene transcripts regulated as a predictor of response to the development of MDS and CMML patients to 5-AZA treatment.Our studies identify transcriptional signature-coding genes regulated development of non-protein-coding and not eres, as correlated good response from MDS and CMML patients for the treatment of 5-AZA and offer new candidates for further evaluation.

Dialysis membrane, 44mm
TX0112	Bio Basic	2m, 2m	EUR 69.14
Product category: Labware/Dialysis Tubing/Membranes

Dialysis membrane, 77mm
TX0113	Bio Basic	2m, 2m	EUR 77.84
Product category: Labware/Dialysis Tubing/Membranes

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-001	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-002	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-003	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-004	GenDepot	Roll	EUR 986

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-005	GenDepot	Roll	EUR 986

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-001	GenDepot	Roll	EUR 490

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-002	GenDepot	Roll	EUR 490

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-003	GenDepot	Roll	EUR 514

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-001	GenDepot	Roll	EUR 604

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-002	GenDepot	Roll	EUR 388

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-003	GenDepot	Roll	EUR 408

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-004	GenDepot	Roll	EUR 456

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-005	GenDepot	Roll	EUR 471

Spectra/Por ® 5 Dry Standard RC Dialysis Tubing
LC9005-001	GenDepot	Roll	EUR 431

Spectra/Por ® 5 Dry Standard RC Dialysis Tubing
LC9005-002	GenDepot	Roll	EUR 571

Add cassette
1292236	Atto	1unit	EUR 447

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m
LC9001-001	GenDepot	Roll	EUR 421

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-002	GenDepot	Roll	EUR 436

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-003	GenDepot	Roll	EUR 436

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-004	GenDepot	Roll	EUR 463

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-005	GenDepot	Roll	EUR 521

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m
LC9001-006	GenDepot	Roll	EUR 601

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m
LC9001-007	GenDepot	Roll	EUR 621

positive electrode cassette (red)
EHS1500-POS	Consort	ea	EUR 116

CUBE Cassette Carrier Adapter
LFRCA-001	BioAssayWorks	Each	EUR 526
Product Category: Lateral-Flow Readers and Equipment
Description: CUBE Cassette Carrier Adapter is an accessory to CUBE Lateral Flow Reader. It could be custom made in order to meet your requirements for cassette/dipstick. The Carrier holds the cassette or dipstick in order to be read from the CUBE Lateral Flow Reader.

Metal Lid for M480 Cassette
M481	ScyTek Laboratories	1 ea.	EUR 141

ATP Binding Cassette Transporter C6 (ABCC6) Antibody
20-abx007239	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx007896	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C13 (ABCC13) Antibody
20-abx007943	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C12 (ABCC12) Antibody
20-abx007986	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A5 (ABCA5) Antibody
20-abx008240	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A9 (ABCA9) Antibody
20-abx008345	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
20-abx008793	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C3 (ABCC3) Antibody
abx025605-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C3 (ABCC3) Antibody
abx025605-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A3 (ABCA3) Antibody
20-abx005231	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx005455	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx005827	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter B8 (ABCB8) Antibody
20-abx005962	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C8 (ABCC8) Antibody
20-abx006205	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C12 (ABCC12) Antibody
abx027270-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C12 (ABCC12) Antibody
abx027270-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C13 (ABCC13) Antibody
20-abx014758	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
abx015757-100ul	Abbexa	100 ul	EUR 411
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
abx015758-100ug	Abbexa	100 ug	EUR 411
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
abx015759-100ug	Abbexa	100 ug	EUR 411
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C12 (ABCC12) Antibody
20-abx213724	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C9 (ABCC9) Antibody
20-abx214164	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter F1 (ABCF1) Antibody
20-abx214913	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter F1 (ABCF1) Antibody
20-abx214914	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx175490	Abbexa	EUR 1177.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter A13 (ABCA13) Antibody
20-abx175491	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C12 (ABCC12) Antibody
20-abx175492	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C13 (ABCC13) Antibody
20-abx175493	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C5 (ABCC5) Antibody
20-abx175494	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C6 (ABCC6) Antibody
20-abx175495	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C6 (ABCC6) Antibody
20-abx175496	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C9 (ABCC9) Antibody
20-abx175497	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter G2 (ABCG2) Antibody
20-abx175498	Abbexa	EUR 1135.00 EUR 551.00	1 mg 200 ug
Please enquire.

ATP Binding Cassette Transporter C10 (ABCC10) Antibody
20-abx210755	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G1 (ABCG1) Antibody
20-abx211076	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G1 (ABCG1) Antibody
20-abx211153	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C3 (ABCC3) Antibody
20-abx211522	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
20-abx212034	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter F2 (ABCF2) Antibody
20-abx212451	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter F2 (ABCF2) Antibody
20-abx212586	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter E1 (ABCE1) Antibody
20-abx213413	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter E1 (ABCE1) Antibody
20-abx213414	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G4 (ABCG4) Antibody
20-abx213415	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
20-abx213514	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx210298	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G2 (ABCG2) Antibody
20-abx210354	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G2 (ABCG2) Antibody
20-abx210395	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
20-abx210611	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx103801	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter G1 (ABCG1) Antibody
20-abx103802	Abbexa	EUR 411.00 EUR 133.00 EUR 1149.00 EUR 565.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx111159	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx111164	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter D1 (ABCD1) Antibody
20-abx111165	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter E1 (ABCE1) Antibody
20-abx111166	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G8 (ABCG8) Antibody
abx117169-100ug	Abbexa	100 ug	EUR 467
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
20-abx123998	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx124284	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C5 (ABCC5) Antibody
20-abx125480	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx128016	Abbexa	EUR 411.00 EUR 133.00 EUR 1149.00 EUR 565.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter A12 (ABCA12) Antibody
20-abx128076	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx128088	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter C4 (ABCC4) Antibody
20-abx128089	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
abx037364-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
abx037564-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A13 (ABCA13) Antibody
abx037596-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
abx037631-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter C10 (ABCC10) Antibody
abx037660-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A6 (ABCA6) Antibody
abx037661-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A5 (ABCA5) Antibody
abx037916-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.

ATP Binding Cassette Transporter A3 (ABCA3) Antibody
abx038096-100ug	Abbexa	100 ug	EUR 391
Shipped within 5-10 working days.