myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) characterized by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse the epigenetic repression, such as 5-azacytidine (5-AZA), induces hematologic improvement in half of the patients treated.
Although the underlying mechanisms of therapeutic efficacy is not yet clear, the induction of endogenous retroelements (eres) has hypothesised.Using RNA sequencing (RNA-seq), we compared the transcriptional Eres in bone marrow HSCs of a new cohort of MDS and chronic myelomonocytic leukemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and patients with AML.
We further examined the ERE transcription using a comprehensive explanation ERE partially-overlapping transcripts expressed in HSCs, produced here by de novo assembly and supported by transcripts of full-length RNA-seq.Consistent with previous reports, we found that treatment with 5- AZA increased representation of ERE-derived RNA-seq reads in the transcriptome. However, the increase is comparable between treatment response and failure.
Extended view HSC transcription diversity offered by de novo assembly transcripts against Eres 5-AZA-responsive as a determinant of treatment outcome. In contrast, pre-treatment revealed expression and alternative splicing gene transcripts regulated as a predictor of response to the development of MDS and CMML patients to 5-AZA treatment.Our studies identify transcriptional signature-coding genes regulated development of non-protein-coding and not eres, as correlated good response from MDS and CMML patients for the treatment of 5-AZA and offer new candidates for further evaluation.
Dialysis Bagholder clip Beakers |
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BAF182370000-6EA | Scientific Laboratory Supplies | PK6 | EUR 37.8 |
Mini Dialysis Kit 1 kDa cutoff 2mL |
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80648394 | Scientific Laboratory Supplies | EACH | EUR 555.6 |
Mini Dialysis Kit 8 kDa cutoff 2mL |
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80648432 | Scientific Laboratory Supplies | EACH | EUR 555.6 |
Mini Dialysis Kit 1 kDa cutoff 250 ul |
|||
80648375 | Scientific Laboratory Supplies | EACH | EUR 555.6 |
Mini Dialysis Kit 8 kDa cutoff 250 ul |
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80648413 | Scientific Laboratory Supplies | EACH | EUR 555.6 |
Visking Dialysis Tubing Clips - Gripping Width 44mm |
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TUB2040 | Scientific Laboratory Supplies | PK10 | EUR 42.69 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-002 | GenDepot | Roll | EUR 644.4 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
|||
LC9002-003 | GenDepot | Roll | EUR 644.4 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-004 | GenDepot | Roll | EUR 1183.2 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
|||
LC9002-005 | GenDepot | Roll | EUR 1183.2 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
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LC9003-001 | GenDepot | Roll | EUR 588 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
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LC9003-002 | GenDepot | Roll | EUR 588 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
|||
LC9003-003 | GenDepot | Roll | EUR 616.8 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
|||
LC9004-001 | GenDepot | Roll | EUR 724.8 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
|||
LC9004-002 | GenDepot | Roll | EUR 465.6 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
|||
LC9004-003 | GenDepot | Roll | EUR 489.6 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
|||
LC9004-004 | GenDepot | Roll | EUR 547.2 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
|||
LC9004-005 | GenDepot | Roll | EUR 565.2 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
|||
LC9005-001 | GenDepot | Roll | EUR 517.2 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
|||
LC9005-002 | GenDepot | Roll | EUR 685.2 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
|||
LC9002-001 | GenDepot | Roll | EUR 644.4 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m |
|||
LC9001-001 | GenDepot | Roll | EUR 505.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
|||
LC9001-002 | GenDepot | Roll | EUR 523.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
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LC9001-003 | GenDepot | Roll | EUR 523.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
|||
LC9001-004 | GenDepot | Roll | EUR 555.6 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
|||
LC9001-005 | GenDepot | Roll | EUR 625.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
|||
LC9001-006 | GenDepot | Roll | EUR 721.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
|||
LC9001-007 | GenDepot | Roll | EUR 745.2 |
Visking Dialysis Tubing - 0.03 x 14.3mm (Wall Thickness x Diam) - 30m |
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TUB2002 | Scientific Laboratory Supplies | 30MTR | EUR 91.39 |
Visking Dialysis Tubing - 0.03 x 15.9mm (Wall Thickness x Diam) - 30m |
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TUB2004 | Scientific Laboratory Supplies | 30MTR | EUR 116.2 |
Visking Dialysis Tubing - 0.03 x 17.5mm (Wall Thickness x Diam) - 30m |
|||
TUB2006 | Scientific Laboratory Supplies | 30MTR | EUR 105.75 |
Visking Dialysis Tubing - 0.03 x 19.0mm (Wall Thickness x Diam) - 30m |
|||
TUB2008 | Scientific Laboratory Supplies | 30MTR | EUR 92.7 |
Visking Dialysis Tubing - 0.03 x 21.5mm (Wall Thickness x Diam) - 30m |
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TUB2010 | Scientific Laboratory Supplies | 30MTR | EUR 112.28 |
Visking Dialysis Tubing - 0.03 x 23.8mm (Wall Thickness x Diam) - 30m |
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TUB2012 | Scientific Laboratory Supplies | 30MTR | EUR 104.45 |
Visking Dialysis Tubing - 0.03 x 25.4mm (Wall Thickness x Diam) - 30m |
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TUB2014 | Scientific Laboratory Supplies | 30MTR | EUR 104.45 |
Visking Dialysis Tubing - 0.03 x 28.6mm (Wall Thickness x Diam) - 30m |
|||
TUB2016 | Scientific Laboratory Supplies | 30MTR | EUR 110.98 |
Visking Dialysis Tubing - 0.04 x 31.7mm (Wall Thickness x Diam) - 30m |
|||
TUB2018 | Scientific Laboratory Supplies | 15MTR | EUR 99.23 |
Visking Dialysis Tubing - 0.04 x 38.1mm (Wall Thickness x Diam) - 30m |
|||
TUB2020 | Scientific Laboratory Supplies | 15MTR | EUR 147.53 |
Visking Dialysis Tubing - 0.05 x 50.8mm (Wall Thickness x Diam) - 15m |
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TUB2024 | Scientific Laboratory Supplies | 15MTR | EUR 147.53 |
Visking Dialysis Tubing - 0.09 x 69.8mm (Wall Thickness x Diam) - 30m |
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TUB2030 | Scientific Laboratory Supplies | 15MTR | EUR 237.62 |
Visking Dialysis Tubing - 0.12 x 82.5mm (Wall Thickness x Diam) - 15m |
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TUB2032 | Scientific Laboratory Supplies | 15MTR | EUR 237.62 |
Visking Dialysis Tubing - 0.12 x 95.2mm (Wall Thickness x Diam) - 15m |
|||
TUB2034 | Scientific Laboratory Supplies | 15MTR | EUR 298.98 |
Visking Dialysis Tubing - 0.12 x 114.3mm (Wall Thickness x Diam) - 15m |
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TUB2036 | Scientific Laboratory Supplies | 15MTR | EUR 327.71 |
Visking Dialysis Tubing - 0.12 x 139.7mm (Wall Thickness x Diam) - 15m |
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TUB2038 | Scientific Laboratory Supplies | EACH | EUR 383.85 |
Add cassette |
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1292236 | Atto | 1unit | EUR 536.4 |
Cassette Lilac |
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HIS0117 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Sub Blot Mini Cassette |
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SB10C | Scientific Laboratory Supplies | EACH | EUR 61.2 |
Sub Blot Maxi Cassette |
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SB20C | Scientific Laboratory Supplies | EACH | EUR 102 |
omniPAGE Mini Wide Cassette |
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SB10WC | Scientific Laboratory Supplies | EACH | EUR 73.2 |
CryoEM AutoGrid Cassette Puck |
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M-CEM-AGC-P1 | MiTeGen | 1 EACH | EUR 587 |
Description: CryoEM AutoGrid Cassette Puck |
SSRL Cassette Transfer Handle |
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M-CP-111-003 | MiTeGen | 1 UNIT | EUR 460 |
Description: SSRL Cassette Transfer Handle |
CUBE Cassette Carrier Adapter |
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LFRCA-001 | BioAssayWorks | Each | EUR 631.2 |
Description: CUBE Cassette Carrier Adapter is an accessory to CUBE Lateral Flow Reader. It could be custom made in order to meet your requirements for cassette/dipstick. The Carrier holds the cassette or dipstick in order to be read from the CUBE Lateral Flow Reader. |
Metal Lid for M480 Cassette |
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M481 | ScyTek Laboratories | 1 ea. | EUR 169.2 |
Simport Embedding Cassette Tan |
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HIS0027 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Tan |
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HIS0038 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Tan |
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HIS0049 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Tan |
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HIS0060 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Tan |
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HIS0071 | Scientific Laboratory Supplies | PK1500 | EUR 398.4 |
Simport Embedding Cassette Tan |
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HIS0082 | Scientific Laboratory Supplies | PK1500 | EUR 387.6 |
Simport Embedding Cassette Tan |
|||
HIS0093 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette Tan |
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HIS0104 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Tan |
|||
HIS0115 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Tan |
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HIS0126 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Tan |
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HIS0159 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Tan |
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HIS0181 | Scientific Laboratory Supplies | PK2000 | EUR 518.4 |
Uni Adj Macro Cassette Clamp |
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HIS3030 | Scientific Laboratory Supplies | EACH | EUR 1069.2 |
Cassette Loading Station Insert |
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M-CEM-AGC-PLSI1 | MiTeGen | 1 EACH | EUR 464 |
Description: Cassette Loading Station Insert |
positive electrode cassette (red) |
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EHS1500-POS | Consort | ea | EUR 139.2 |
Simport Embedding Cassette Pink |
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HIS0010 | Scientific Laboratory Supplies | PK1500 | EUR 248.4 |
Simport Embedding Cassette Grey |
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HIS0028 | Scientific Laboratory Supplies | PK1500 | EUR 210 |
Simport Embedding Cassette Grey |
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HIS0039 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Aqua |
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HIS0042 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Pink |
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HIS0044 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Blue |
|||
HIS0047 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Grey |
|||
HIS0050 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Aqua |
|||
HIS0053 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Pink |
|||
HIS0055 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Blue |
|||
HIS0058 | Scientific Laboratory Supplies | PK1500 | EUR 277.2 |
Simport Embedding Cassette Grey |
|||
HIS0061 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Aqua |
|||
HIS0064 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Grey |
|||
HIS0072 | Scientific Laboratory Supplies | PK1500 | EUR 398.4 |
Simport Embedding Cassette Aqua |
|||
HIS0075 | Scientific Laboratory Supplies | PK1500 | EUR 398.4 |
Simport Embedding Cassette Grey |
|||
HIS0083 | Scientific Laboratory Supplies | PK1500 | EUR 387.6 |
Simport Embedding Cassette Aqua |
|||
HIS0086 | Scientific Laboratory Supplies | PK1500 | EUR 387.6 |
Simport Embedding Cassette Pink |
|||
HIS0088 | Scientific Laboratory Supplies | PK1000 | EUR 186 |
Simport Embedding Cassette Blue |
|||
HIS0091 | Scientific Laboratory Supplies | PK1000 | EUR 186 |
Simport Embedding Cassette Grey |
|||
HIS0094 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette Aqua |
|||
HIS0097 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette Pink |
|||
HIS0099 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Blue |
|||
HIS0102 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Grey |
|||
HIS0105 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Aqua |
|||
HIS0108 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Pink |
|||
HIS0110 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Blue |
|||
HIS0113 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Grey |
|||
HIS0116 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Aqua |
|||
HIS0119 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Pink |
|||
HIS0121 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Blue |
|||
HIS0124 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Grey |
|||
HIS0127 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Aqua |
|||
HIS0130 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Pink |
|||
HIS0154 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Blue |
|||
HIS0157 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Grey |
|||
HIS0160 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Aqua |
|||
HIS0163 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Pink |
|||
HIS0176 | Scientific Laboratory Supplies | PK2000 | EUR 518.4 |
Simport Embedding Cassette Blue |
|||
HIS0179 | Scientific Laboratory Supplies | PK2000 | EUR 518.4 |
Simport Embedding Cassette Grey |
|||
HIS0182 | Scientific Laboratory Supplies | PK2000 | EUR 518.4 |
Simport Embedding Cassette Aqua |
|||
HIS0185 | Scientific Laboratory Supplies | PK2000 | EUR 518.4 |
Simport Embedding Cassette White |
|||
HIS0009 | Scientific Laboratory Supplies | PK1500 | EUR 248.4 |
Simport Embedding Cassette Green |
|||
HIS0011 | Scientific Laboratory Supplies | PK1500 | EUR 248.4 |
Simport Embedding Cassette Peach |
|||
HIS0014 | Scientific Laboratory Supplies | PK1500 | EUR 248.4 |
Simport Embedding Cassette Peach |
|||
HIS0026 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Peach |
|||
HIS0037 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette Lilac |
|||
HIS0040 | Scientific Laboratory Supplies | PK1500 | EUR 228 |
Simport Embedding Cassette White |
|||
HIS0043 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Green |
|||
HIS0045 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Peach |
|||
HIS0048 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Lilac |
|||
HIS0051 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette White |
|||
HIS0054 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Green |
|||
HIS0056 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Peach |
|||
HIS0059 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Lilac |
|||
HIS0062 | Scientific Laboratory Supplies | PK1500 | EUR 290.4 |
Simport Embedding Cassette Peach |
|||
HIS0070 | Scientific Laboratory Supplies | PK1500 | EUR 398.4 |
Simport Embedding Cassette Lilac |
|||
HIS0073 | Scientific Laboratory Supplies | PK1500 | EUR 398.4 |
Simport Embedding Cassette Peach |
|||
HIS0081 | Scientific Laboratory Supplies | PK1500 | EUR 387.6 |
Simport Embedding Cassette Lilac |
|||
HIS0084 | Scientific Laboratory Supplies | PK1500 | EUR 387.6 |
Simport Embedding Cassette White |
|||
HIS0087 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette Green |
|||
HIS0089 | Scientific Laboratory Supplies | PK1000 | EUR 186 |
Simport Embedding Cassette Peach |
|||
HIS0092 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette Lilac |
|||
HIS0095 | Scientific Laboratory Supplies | PK1000 | EUR 201.6 |
Simport Embedding Cassette White |
|||
HIS0098 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Green |
|||
HIS0100 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Peach |
|||
HIS0103 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette Lilac |
|||
HIS0106 | Scientific Laboratory Supplies | PK1000 | EUR 254.4 |
Simport Embedding Cassette White |
|||
HIS0109 | Scientific Laboratory Supplies | PK1000 | EUR 511.8 |
Simport Embedding Cassette Green |
|||
HIS0111 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Peach |
|||
HIS0114 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette White |
|||
HIS0120 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Green |
|||
HIS0122 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Peach |
|||
HIS0125 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Lilac |
|||
HIS0128 | Scientific Laboratory Supplies | PK1000 | EUR 508.8 |
Simport Embedding Cassette Green |
|||
HIS0155 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Peach |
|||
HIS0158 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |
Simport Embedding Cassette Lilac |
|||
HIS0161 | Scientific Laboratory Supplies | PK2000 | EUR 517.2 |