Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression.

myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) characterized by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse the epigenetic repression, such as 5-azacytidine (5-AZA), induces hematologic improvement in half of the patients treated.

Although the underlying mechanisms of therapeutic efficacy is not yet clear, the induction of endogenous retroelements (eres) has hypothesised.Using RNA sequencing (RNA-seq), we compared the transcriptional Eres in bone marrow HSCs of a new cohort of MDS and chronic myelomonocytic leukemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and patients with AML.

We further examined the ERE transcription using a comprehensive explanation ERE partially-overlapping transcripts expressed in HSCs, produced here by de novo assembly and supported by transcripts of full-length RNA-seq.Consistent with previous reports, we found that treatment with 5- AZA increased representation of ERE-derived RNA-seq reads in the transcriptome. However, the increase is comparable between treatment response and failure.

Extended view HSC transcription diversity offered by de novo assembly transcripts against Eres 5-AZA-responsive as a determinant of treatment outcome. In contrast, pre-treatment revealed expression and alternative splicing gene transcripts regulated as a predictor of response to the development of MDS and CMML patients to 5-AZA treatment.Our studies identify transcriptional signature-coding genes regulated development of non-protein-coding and not eres, as correlated good response from MDS and CMML patients for the treatment of 5-AZA and offer new candidates for further evaluation.

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-001	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-002	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-003	GenDepot	Roll	EUR 537

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-004	GenDepot	Roll	EUR 986

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing
LC9002-005	GenDepot	Roll	EUR 986

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-001	GenDepot	Roll	EUR 490

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-002	GenDepot	Roll	EUR 490

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing
LC9003-003	GenDepot	Roll	EUR 514

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-001	GenDepot	Roll	EUR 604

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-002	GenDepot	Roll	EUR 388

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-003	GenDepot	Roll	EUR 408

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-004	GenDepot	Roll	EUR 456

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing
LC9004-005	GenDepot	Roll	EUR 471

Spectra/Por ® 5 Dry Standard RC Dialysis Tubing
LC9005-001	GenDepot	Roll	EUR 431

Spectra/Por ® 5 Dry Standard RC Dialysis Tubing
LC9005-002	GenDepot	Roll	EUR 571

Add cassette
1292236	Atto	1unit	EUR 447

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m
LC9001-001	GenDepot	Roll	EUR 421

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-002	GenDepot	Roll	EUR 436

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-003	GenDepot	Roll	EUR 436

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-004	GenDepot	Roll	EUR 463

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m
LC9001-005	GenDepot	Roll	EUR 521

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m
LC9001-006	GenDepot	Roll	EUR 601

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m
LC9001-007	GenDepot	Roll	EUR 621

positive electrode cassette (red)
EHS1500-POS	Consort	ea	EUR 116

CUBE Cassette Carrier Adapter
LFRCA-001	BioAssayWorks	Each	EUR 526
Description: CUBE Cassette Carrier Adapter is an accessory to CUBE Lateral Flow Reader. It could be custom made in order to meet your requirements for cassette/dipstick. The Carrier holds the cassette or dipstick in order to be read from the CUBE Lateral Flow Reader.

Metal Lid for M480 Cassette
M481	ScyTek Laboratories	1 ea.	EUR 141

ATP Binding Cassette Transporter A5 (ABCA5) Antibody
20-abx301853	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx301860	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

ATP Binding Cassette Transporter C9 (ABCC9) Antibody
20-abx302237	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

ATP Binding Cassette Transporter A3 (ABCA3) Antibody
20-abx147857	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

ATP Binding Cassette Transporter A12 (ABCA12) Antibody
20-abx147861	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

ATP Binding Cassette Transporter A9 (ABCA9) Antibody
20-abx147865	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

ATP Binding Cassette Transporter C9 (ABCC9) Antibody
abx147871-100ug	Abbexa	100 ug	EUR 439

ATP Binding Cassette Transporter A3 (ABCA3) Antibody
20-abx128628	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C3 (ABCC3) Antibody
20-abx129112	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A13 (ABCA13) Antibody
20-abx130546	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx130547	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx130548	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A5 (ABCA5) Antibody
20-abx130550	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A6 (ABCA6) Antibody
20-abx130551	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A9 (ABCA9) Antibody
20-abx130555	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A9 (ABCA9) Antibody
20-abx130556	Abbexa	EUR 467.00 EUR 133.00 EUR 1344.00 EUR 634.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A9 (ABCA9) Antibody
20-abx130557	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B4 (ABCB4) Antibody
20-abx130561	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B7 (ABCB7) Antibody
20-abx130563	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B7 (ABCB7) Antibody
20-abx130564	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B8 (ABCB8) Antibody
20-abx130565	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B8 (ABCB8) Antibody
20-abx130566	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B8 (ABCB8) Antibody
20-abx130567	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B9 (ABCB9) Antibody
20-abx130568	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B9 (ABCB9) Antibody
20-abx130569	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C11 (ABCC11) Antibody
20-abx130571	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C11 (ABCC11) Antibody
20-abx130572	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C6 (ABCC6) Antibody
20-abx130573	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C6 (ABCC6) Antibody
20-abx130574	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter D1 (ABCD1) Antibody
20-abx130575	Abbexa	EUR 398.00 EUR 133.00 EUR 1094.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter D2 (ABCD2) Antibody
20-abx130576	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
20-abx130577	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
20-abx130578	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter E1 (ABCE1) Antibody
20-abx130579	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter F1 (ABCF1) Antibody
20-abx130580	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter F1 (ABCF1) Antibody
20-abx130581	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter F2 (ABCF2) Antibody
20-abx130582	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G4 (ABCG4) Antibody
20-abx130583	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
20-abx130584	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G8 (ABCG8) Antibody
20-abx130585	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G8 (ABCG8) Antibody
20-abx130586	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G2 (ABCG2) Antibody
20-abx130861	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C5 (ABCC5) Antibody
20-abx125480	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx128016	Abbexa	EUR 411.00 EUR 133.00 EUR 1149.00 EUR 565.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter A12 (ABCA12) Antibody
20-abx128076	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx128088	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C4 (ABCC4) Antibody
20-abx128089	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G2 (ABCG2) Antibody
20-abx128137	Abbexa	EUR 300.00 EUR 133.00 EUR 759.00 EUR 398.00 EUR 258.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C10 (ABCC10) Antibody
20-abx128395	Abbexa	EUR 453.00 EUR 133.00 EUR 1316.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter C8 (ABCC8) Antibody
20-abx128425	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G8 (ABCG8) Antibody
abx117169-100ug	Abbexa	100 ug	EUR 467

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx111159	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
20-abx111164	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

ATP Binding Cassette Transporter D1 (ABCD1) Antibody
20-abx111165	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

ATP Binding Cassette Transporter E1 (ABCE1) Antibody
20-abx111166	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

ATP Binding Cassette Transporter C3 (ABCC3) Antibody
20-abx135793	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
20-abx123998	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

ATP Binding Cassette Transporter A2 (ABCA2) Antibody
20-abx124284	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

ATP Binding Cassette Transporter A1 (ABCA1) Antibody
20-abx103801	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter G1 (ABCG1) Antibody
20-abx103802	Abbexa	EUR 411.00 EUR 133.00 EUR 1149.00 EUR 565.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

ATP Binding Cassette Transporter B4 (ABCB4) Antibody
20-abx110010	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

ATP Binding Cassette Transporter G8 (ABCG8) Antibody
abx038435-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter A6 (ABCA6) Antibody
abx038443-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter C2 (ABCC2) Antibody
abx037364-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter G5 (ABCG5) Antibody
abx037564-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter A13 (ABCA13) Antibody
abx037596-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter D4 (ABCD4) Antibody
abx037631-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter C10 (ABCC10) Antibody
abx037660-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter A6 (ABCA6) Antibody
abx037661-100ug	Abbexa	100 ug	EUR 391

ATP Binding Cassette Transporter A5 (ABCA5) Antibody
abx037916-100ug	Abbexa	100 ug	EUR 391