myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) characterized by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse the epigenetic repression, such as 5-azacytidine (5-AZA), induces hematologic improvement in half of the patients treated.
Although the underlying mechanisms of therapeutic efficacy is not yet clear, the induction of endogenous retroelements (eres) has hypothesised.Using RNA sequencing (RNA-seq), we compared the transcriptional Eres in bone marrow HSCs of a new cohort of MDS and chronic myelomonocytic leukemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and patients with AML.
We further examined the ERE transcription using a comprehensive explanation ERE partially-overlapping transcripts expressed in HSCs, produced here by de novo assembly and supported by transcripts of full-length RNA-seq.Consistent with previous reports, we found that treatment with 5- AZA increased representation of ERE-derived RNA-seq reads in the transcriptome. However, the increase is comparable between treatment response and failure.
Extended view HSC transcription diversity offered by de novo assembly transcripts against Eres 5-AZA-responsive as a determinant of treatment outcome. In contrast, pre-treatment revealed expression and alternative splicing gene transcripts regulated as a predictor of response to the development of MDS and CMML patients to 5-AZA treatment.Our studies identify transcriptional signature-coding genes regulated development of non-protein-coding and not eres, as correlated good response from MDS and CMML patients for the treatment of 5-AZA and offer new candidates for further evaluation.
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-001 | GenDepot | Roll | EUR 537 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-002 | GenDepot | Roll | EUR 537 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-003 | GenDepot | Roll | EUR 537 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-004 | GenDepot | Roll | EUR 986 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
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LC9002-005 | GenDepot | Roll | EUR 986 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
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LC9003-001 | GenDepot | Roll | EUR 490 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
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LC9003-002 | GenDepot | Roll | EUR 490 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
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LC9003-003 | GenDepot | Roll | EUR 514 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
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LC9004-001 | GenDepot | Roll | EUR 604 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
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LC9004-002 | GenDepot | Roll | EUR 388 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
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LC9004-003 | GenDepot | Roll | EUR 408 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
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LC9004-004 | GenDepot | Roll | EUR 456 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
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LC9004-005 | GenDepot | Roll | EUR 471 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
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LC9005-001 | GenDepot | Roll | EUR 431 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
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LC9005-002 | GenDepot | Roll | EUR 571 |
Add cassette |
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1292236 | Atto | 1unit | EUR 447 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m |
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LC9001-001 | GenDepot | Roll | EUR 421 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
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LC9001-002 | GenDepot | Roll | EUR 436 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
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LC9001-003 | GenDepot | Roll | EUR 436 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
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LC9001-004 | GenDepot | Roll | EUR 463 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
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LC9001-005 | GenDepot | Roll | EUR 521 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
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LC9001-006 | GenDepot | Roll | EUR 601 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
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LC9001-007 | GenDepot | Roll | EUR 621 |
positive electrode cassette (red) |
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EHS1500-POS | Consort | ea | EUR 116 |
CUBE Cassette Carrier Adapter |
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LFRCA-001 | BioAssayWorks | Each | EUR 526 |
Description: CUBE Cassette Carrier Adapter is an accessory to CUBE Lateral Flow Reader. It could be custom made in order to meet your requirements for cassette/dipstick. The Carrier holds the cassette or dipstick in order to be read from the CUBE Lateral Flow Reader. |
Metal Lid for M480 Cassette |
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M481 | ScyTek Laboratories | 1 ea. | EUR 141 |
ATP Binding Cassette Transporter A5 (ABCA5) Antibody |
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20-abx301853 | Abbexa |
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ATP Binding Cassette Transporter A2 (ABCA2) Antibody |
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20-abx301860 | Abbexa |
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ATP Binding Cassette Transporter C9 (ABCC9) Antibody |
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20-abx302237 | Abbexa |
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ATP Binding Cassette Transporter A3 (ABCA3) Antibody |
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20-abx147857 | Abbexa |
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ATP Binding Cassette Transporter A12 (ABCA12) Antibody |
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20-abx147861 | Abbexa |
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ATP Binding Cassette Transporter A9 (ABCA9) Antibody |
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20-abx147865 | Abbexa |
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ATP Binding Cassette Transporter C9 (ABCC9) Antibody |
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abx147871-100ug | Abbexa | 100 ug | EUR 439 |
ATP Binding Cassette Transporter A3 (ABCA3) Antibody |
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20-abx128628 | Abbexa |
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ATP Binding Cassette Transporter C3 (ABCC3) Antibody |
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20-abx129112 | Abbexa |
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ATP Binding Cassette Transporter A13 (ABCA13) Antibody |
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20-abx130546 | Abbexa |
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ATP Binding Cassette Transporter A2 (ABCA2) Antibody |
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20-abx130547 | Abbexa |
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ATP Binding Cassette Transporter A2 (ABCA2) Antibody |
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20-abx130548 | Abbexa |
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ATP Binding Cassette Transporter A5 (ABCA5) Antibody |
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20-abx130550 | Abbexa |
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ATP Binding Cassette Transporter A6 (ABCA6) Antibody |
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20-abx130551 | Abbexa |
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ATP Binding Cassette Transporter A9 (ABCA9) Antibody |
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20-abx130555 | Abbexa |
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ATP Binding Cassette Transporter A9 (ABCA9) Antibody |
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20-abx130556 | Abbexa |
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ATP Binding Cassette Transporter A9 (ABCA9) Antibody |
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20-abx130557 | Abbexa |
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ATP Binding Cassette Transporter B4 (ABCB4) Antibody |
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20-abx130561 | Abbexa |
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ATP Binding Cassette Transporter B7 (ABCB7) Antibody |
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20-abx130563 | Abbexa |
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ATP Binding Cassette Transporter B7 (ABCB7) Antibody |
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20-abx130564 | Abbexa |
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ATP Binding Cassette Transporter B8 (ABCB8) Antibody |
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20-abx130565 | Abbexa |
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ATP Binding Cassette Transporter B8 (ABCB8) Antibody |
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20-abx130566 | Abbexa |
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ATP Binding Cassette Transporter B8 (ABCB8) Antibody |
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20-abx130567 | Abbexa |
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ATP Binding Cassette Transporter B9 (ABCB9) Antibody |
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20-abx130568 | Abbexa |
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ATP Binding Cassette Transporter B9 (ABCB9) Antibody |
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20-abx130569 | Abbexa |
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ATP Binding Cassette Transporter C11 (ABCC11) Antibody |
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20-abx130571 | Abbexa |
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ATP Binding Cassette Transporter C11 (ABCC11) Antibody |
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20-abx130572 | Abbexa |
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ATP Binding Cassette Transporter C6 (ABCC6) Antibody |
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20-abx130573 | Abbexa |
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ATP Binding Cassette Transporter C6 (ABCC6) Antibody |
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20-abx130574 | Abbexa |
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ATP Binding Cassette Transporter D1 (ABCD1) Antibody |
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20-abx130575 | Abbexa |
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ATP Binding Cassette Transporter D2 (ABCD2) Antibody |
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20-abx130576 | Abbexa |
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ATP Binding Cassette Transporter D4 (ABCD4) Antibody |
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20-abx130577 | Abbexa |
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ATP Binding Cassette Transporter D4 (ABCD4) Antibody |
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20-abx130578 | Abbexa |
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ATP Binding Cassette Transporter E1 (ABCE1) Antibody |
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20-abx130579 | Abbexa |
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ATP Binding Cassette Transporter F1 (ABCF1) Antibody |
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20-abx130580 | Abbexa |
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ATP Binding Cassette Transporter F1 (ABCF1) Antibody |
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20-abx130581 | Abbexa |
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ATP Binding Cassette Transporter F2 (ABCF2) Antibody |
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20-abx130582 | Abbexa |
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ATP Binding Cassette Transporter G4 (ABCG4) Antibody |
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20-abx130583 | Abbexa |
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ATP Binding Cassette Transporter G5 (ABCG5) Antibody |
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20-abx130584 | Abbexa |
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ATP Binding Cassette Transporter G8 (ABCG8) Antibody |
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20-abx130585 | Abbexa |
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ATP Binding Cassette Transporter G8 (ABCG8) Antibody |
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20-abx130586 | Abbexa |
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ATP Binding Cassette Transporter G2 (ABCG2) Antibody |
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20-abx130861 | Abbexa |
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ATP Binding Cassette Transporter C5 (ABCC5) Antibody |
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20-abx125480 | Abbexa |
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ATP Binding Cassette Transporter A1 (ABCA1) Antibody |
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20-abx128016 | Abbexa |
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ATP Binding Cassette Transporter A12 (ABCA12) Antibody |
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20-abx128076 | Abbexa |
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ATP Binding Cassette Transporter C2 (ABCC2) Antibody |
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20-abx128088 | Abbexa |
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ATP Binding Cassette Transporter C4 (ABCC4) Antibody |
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20-abx128089 | Abbexa |
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ATP Binding Cassette Transporter G2 (ABCG2) Antibody |
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20-abx128137 | Abbexa |
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ATP Binding Cassette Transporter C10 (ABCC10) Antibody |
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20-abx128395 | Abbexa |
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ATP Binding Cassette Transporter C8 (ABCC8) Antibody |
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20-abx128425 | Abbexa |
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ATP Binding Cassette Transporter G8 (ABCG8) Antibody |
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abx117169-100ug | Abbexa | 100 ug | EUR 467 |
ATP Binding Cassette Transporter A2 (ABCA2) Antibody |
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20-abx111159 | Abbexa |
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ATP Binding Cassette Transporter C2 (ABCC2) Antibody |
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20-abx111164 | Abbexa |
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ATP Binding Cassette Transporter D1 (ABCD1) Antibody |
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20-abx111165 | Abbexa |
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ATP Binding Cassette Transporter E1 (ABCE1) Antibody |
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20-abx111166 | Abbexa |
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ATP Binding Cassette Transporter C3 (ABCC3) Antibody |
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20-abx135793 | Abbexa |
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ATP Binding Cassette Transporter G5 (ABCG5) Antibody |
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20-abx123998 | Abbexa |
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ATP Binding Cassette Transporter A2 (ABCA2) Antibody |
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20-abx124284 | Abbexa |
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ATP Binding Cassette Transporter A1 (ABCA1) Antibody |
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20-abx103801 | Abbexa |
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ATP Binding Cassette Transporter G1 (ABCG1) Antibody |
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20-abx103802 | Abbexa |
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ATP Binding Cassette Transporter B4 (ABCB4) Antibody |
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20-abx110010 | Abbexa |
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ATP Binding Cassette Transporter G8 (ABCG8) Antibody |
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abx038435-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter A6 (ABCA6) Antibody |
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abx038443-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter C2 (ABCC2) Antibody |
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abx037364-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter G5 (ABCG5) Antibody |
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abx037564-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter A13 (ABCA13) Antibody |
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abx037596-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter D4 (ABCD4) Antibody |
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abx037631-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter C10 (ABCC10) Antibody |
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abx037660-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter A6 (ABCA6) Antibody |
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abx037661-100ug | Abbexa | 100 ug | EUR 391 |
ATP Binding Cassette Transporter A5 (ABCA5) Antibody |
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abx037916-100ug | Abbexa | 100 ug | EUR 391 |