myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) characterized by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse the epigenetic repression, such as 5-azacytidine (5-AZA), induces hematologic improvement in half of the patients treated.
Although the underlying mechanisms of therapeutic efficacy is not yet clear, the induction of endogenous retroelements (eres) has hypothesised.Using RNA sequencing (RNA-seq), we compared the transcriptional Eres in bone marrow HSCs of a new cohort of MDS and chronic myelomonocytic leukemia (CMML) patients before and after 5-AZA treatment with HSCs from healthy donors and patients with AML.
We further examined the ERE transcription using a comprehensive explanation ERE partially-overlapping transcripts expressed in HSCs, produced here by de novo assembly and supported by transcripts of full-length RNA-seq.Consistent with previous reports, we found that treatment with 5- AZA increased representation of ERE-derived RNA-seq reads in the transcriptome. However, the increase is comparable between treatment response and failure.
Extended view HSC transcription diversity offered by de novo assembly transcripts against Eres 5-AZA-responsive as a determinant of treatment outcome. In contrast, pre-treatment revealed expression and alternative splicing gene transcripts regulated as a predictor of response to the development of MDS and CMML patients to 5-AZA treatment.Our studies identify transcriptional signature-coding genes regulated development of non-protein-coding and not eres, as correlated good response from MDS and CMML patients for the treatment of 5-AZA and offer new candidates for further evaluation.
Dialysis membrane, 77mm |
TX0113 |
Bio Basic |
2m, 2m |
EUR 93.41 |
|
Dialysis Tubing No. 4 (DM003) |
LA393-1MT |
EWC Diagnostics |
1 unit |
EUR 7.6 |
Description: Dialysis Tubing No. 4 (DM003) |
Dialysis Tubing Wash Buffer 5X |
40120355-1 |
Bio-WORLD |
250 ml |
EUR 33.21 |
Dialysis Tubing Wash Buffer 5X |
40120355-2 |
Bio-WORLD |
500 ml |
EUR 50.17 |
Dialysis Membrane-50 Av.flat width - |
LA387-10MT |
EWC Diagnostics |
1 unit |
EUR 60.05 |
Description: Dialysis Membrane-50 Av.flat width - |
Dialysis Membrane-50 Av.flat width - |
LA387-30MT |
EWC Diagnostics |
1 unit |
EUR 161.71 |
Description: Dialysis Membrane-50 Av.flat width - |
Dialysis Membrane-50 Av.flat width - |
LA387-5MT |
EWC Diagnostics |
1 unit |
EUR 34.79 |
Description: Dialysis Membrane-50 Av.flat width - |
Dialysis Membrane-60 Av.flat width - |
LA390-10MT |
EWC Diagnostics |
1 unit |
EUR 60.11 |
Description: Dialysis Membrane-60 Av.flat width - |
Dialysis Membrane-60 Av.flat width - |
LA390-30MT |
EWC Diagnostics |
1 unit |
EUR 166.51 |
Description: Dialysis Membrane-60 Av.flat width - |
Dialysis Membrane-60 Av.flat width - |
LA390-5MT |
EWC Diagnostics |
1 unit |
EUR 34.79 |
Description: Dialysis Membrane-60 Av.flat width - |
Dialysis Membrane-70 Av.flat width - |
LA393-10MT |
EWC Diagnostics |
1 unit |
EUR 60.11 |
Description: Dialysis Membrane-70 Av.flat width - |
Dialysis Membrane-70 Av.flat width - |
LA393-30MT |
EWC Diagnostics |
1 unit |
EUR 166.51 |
Description: Dialysis Membrane-70 Av.flat width - |
Dialysis Membrane-70 Av.flat width - |
LA393-5MT |
EWC Diagnostics |
1 unit |
EUR 34.79 |
Description: Dialysis Membrane-70 Av.flat width - |
Dialysis Closure Clips a perfect |
LA404-10NO |
EWC Diagnostics |
1 unit |
EUR 125.96 |
Description: Dialysis Closure Clips a perfect |
Dialysis Membrane-110 Av.flat width - |
LA395-10MT |
EWC Diagnostics |
1 unit |
EUR 66.93 |
Description: Dialysis Membrane-110 Av.flat width - |
Dialysis Membrane-110 Av.flat width - |
LA395-30MT |
EWC Diagnostics |
1 unit |
EUR 188 |
Description: Dialysis Membrane-110 Av.flat width - |
Dialysis Membrane-110 Av.flat width - |
LA395-5MT |
EWC Diagnostics |
1 unit |
EUR 39.89 |
Description: Dialysis Membrane-110 Av.flat width - |
Dialysis Membrane-135 Av.flat width - |
LA398-10MT |
EWC Diagnostics |
1 unit |
EUR 65.57 |
Description: Dialysis Membrane-135 Av.flat width - |
Dialysis Membrane-135 Av.flat width - |
LA398-30MT |
EWC Diagnostics |
1 unit |
EUR 184.29 |
Description: Dialysis Membrane-135 Av.flat width - |
Dialysis Membrane-135 Av.flat width - |
LA398-5MT |
EWC Diagnostics |
1 unit |
EUR 47.67 |
Description: Dialysis Membrane-135 Av.flat width - |
Dialysis Membrane-150 Av.flat width - |
LA401-10MT |
EWC Diagnostics |
1 unit |
EUR 83.76 |
Description: Dialysis Membrane-150 Av.flat width - |
Dialysis Membrane-150 Av.flat width - |
LA401-30MT |
EWC Diagnostics |
1 unit |
EUR 235.13 |
Description: Dialysis Membrane-150 Av.flat width - |
Dialysis Membrane-150 Av.flat width - |
LA401-5MT |
EWC Diagnostics |
1 unit |
EUR 47.67 |
Description: Dialysis Membrane-150 Av.flat width - |
Dialysis Membrane-135Av.flat width - 39. |
LA398-1MT |
EWC Diagnostics |
1 unit |
EUR 10.12 |
Description: Dialysis Membrane-135Av.flat width - 39. |
Dialysis Membrane-150Av.flat width - 42. |
LA401-1MT |
EWC Diagnostics |
1 unit |
EUR 10.77 |
Description: Dialysis Membrane-150Av.flat width - 42. |
GeBAflex Midi Dialysis, No Buffers (3500) |
43270012-1 |
Bio-WORLD |
10 Tube (s) |
Ask for price |
GeBAflex Midi Dialysis, No Buffers (3500) |
43270012-2 |
Bio-WORLD |
30 Tube (s) |
Ask for price |
GeBAflex Mini Dialysis, No Buffers (12000) |
43270016-1 |
Bio-WORLD |
10 Tube (s) |
Ask for price |
GeBAflex Mini Dialysis, No Buffers (12000) |
43270016-2 |
Bio-WORLD |
30 Tube (s) |
Ask for price |
Dialysis Membrane-50Av. flat width - 24. |
LA387-1MT |
EWC Diagnostics |
1 unit |
EUR 7.6 |
Description: Dialysis Membrane-50Av. flat width - 24. |
Dialysis Membrane-60Av. flat width - 25. |
LA390-1MT |
EWC Diagnostics |
1 unit |
EUR 7.6 |
Description: Dialysis Membrane-60Av. flat width - 25. |
Dialysis Membrane-110Av. flat width - 32 |
LA395-1MT |
EWC Diagnostics |
1 unit |
EUR 8.73 |
Description: Dialysis Membrane-110Av. flat width - 32 |
Dialysis Tubing Size 1 Dia 8/32, 6.3 mm |
LA653-10MT |
EWC Diagnostics |
1 unit |
EUR 372.38 |
Description: Dialysis Tubing Size 1 Dia 8/32, 6.3 mm |
Dialysis Tubing Size 1 Dia 8/32, 6.3 mm |
LA653-30MT |
EWC Diagnostics |
1 unit |
EUR 956.16 |
Description: Dialysis Tubing Size 1 Dia 8/32, 6.3 mm |
GeBAflex Mini Dialysis, No Buffers (6000 MW cut off) |
43270017-1 |
Bio-WORLD |
10 Tube (s) |
Ask for price |
GeBAflex Mini Dialysis, No Buffers (6000 MW cut off) |
43270017-2 |
Bio-WORLD |
30 Tube (s) |
Ask for price |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
LC9002-001 |
GenDepot |
Roll |
EUR 644.4 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
LC9002-002 |
GenDepot |
Roll |
EUR 644.4 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
LC9002-003 |
GenDepot |
Roll |
EUR 644.4 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
LC9002-004 |
GenDepot |
Roll |
EUR 1183.2 |
Spectra/Por ® 2 Dry Standard RC Dialysis Tubing |
LC9002-005 |
GenDepot |
Roll |
EUR 1183.2 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
LC9003-001 |
GenDepot |
Roll |
EUR 588 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
LC9003-002 |
GenDepot |
Roll |
EUR 588 |
Spectra/Por ® 3 Dry Standard RC Dialysis Tubing |
LC9003-003 |
GenDepot |
Roll |
EUR 616.8 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
LC9004-001 |
GenDepot |
Roll |
EUR 724.8 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
LC9004-002 |
GenDepot |
Roll |
EUR 465.6 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
LC9004-003 |
GenDepot |
Roll |
EUR 489.6 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
LC9004-004 |
GenDepot |
Roll |
EUR 547.2 |
Spectra/Por ® 4 Dry Standard RC Dialysis Tubing |
LC9004-005 |
GenDepot |
Roll |
EUR 565.2 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
LC9005-001 |
GenDepot |
Roll |
EUR 517.2 |
Spectra/Por ® 5 Dry Standard RC Dialysis Tubing |
LC9005-002 |
GenDepot |
Roll |
EUR 685.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m |
LC9001-001 |
GenDepot |
Roll |
EUR 505.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
LC9001-002 |
GenDepot |
Roll |
EUR 523.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
LC9001-003 |
GenDepot |
Roll |
EUR 523.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
LC9001-004 |
GenDepot |
Roll |
EUR 555.6 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m |
LC9001-005 |
GenDepot |
Roll |
EUR 625.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
LC9001-006 |
GenDepot |
Roll |
EUR 721.2 |
Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 15 m |
LC9001-007 |
GenDepot |
Roll |
EUR 745.2 |
Add cassette |
1292236 |
Atto |
1unit |
EUR 280.06 |
LentiTitre Cassette |
ATG-LT-02-10 |
Antagene |
10 cassettes |
EUR 600 |
LentiTitre Cassette |
ATG-LT-02-20 |
Antagene |
20 cassettes |
EUR 1000 |
LentiTitre Cassette |
ATG-LT-02-5 |
Antagene |
5 cassettes |
EUR 315 |
BZO Test Cassette |
BZO-D112 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.27 |
AMP Test Cassette |
AMP-1062 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.28 |
MET Test Cassette |
MET-1072 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.28 |
THC Test Cassette |
THC-1092 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.27 |
h-FABP Test Cassette |
HF-1331 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 1.91 |
Troponin I Test Cassette |
TroponinI-1221 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.76 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (AP) |
MBS6453808-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (AP) |
MBS6453808-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (APC) |
MBS6453809-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (APC) |
MBS6453809-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (FITC) |
MBS6453811-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (FITC) |
MBS6453811-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (HRP) |
MBS6453812-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (HRP) |
MBS6453812-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (PE) |
MBS6453818-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (PE) |
MBS6453818-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
Malaria pf/pv Ab Cassette |
INV-911 |
Innovation Biotech |
4.0mm (strip in a card) 25cards/box |
EUR 0.47 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (Biotin) |
MBS6453810-02mL |
MyBiosource |
0.2mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (Biotin) |
MBS6453810-5x02mL |
MyBiosource |
5x0.2mL |
EUR 4250 |
CryoEM AutoGrid Cassette Puck |
M-CEM-AGC-P1 |
MiTeGen |
1 EACH |
EUR 587 |
Description: CryoEM AutoGrid Cassette Puck |
SSRL Cassette Transfer Handle |
M-CP-111-003 |
MiTeGen |
1 UNIT |
EUR 460 |
Description: SSRL Cassette Transfer Handle |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 405) |
MBS6453813-01mL |
MyBiosource |
0.1mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 405) |
MBS6453813-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 490) |
MBS6453814-01mL |
MyBiosource |
0.1mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 490) |
MBS6453814-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 550) |
MBS6453815-01mL |
MyBiosource |
0.1mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 550) |
MBS6453815-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 650) |
MBS6453816-01mL |
MyBiosource |
0.1mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 650) |
MBS6453816-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4250 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 750) |
MBS6453817-01mL |
MyBiosource |
0.1mL |
EUR 980 |
ABCA2 (ATP-Binding Cassette Sub-Family A Member 2, ATP-Binding Cassette Transporter 2, ATP-Binding Cassette 2, ABCA2, ABC2, KIAA1062) (MaxLight 750) |
MBS6453817-5x01mL |
MyBiosource |
5x0.1mL |
EUR 4250 |
positive electrode cassette (red) |
EHS1500-POS |
Consort |
ea |
EUR 139.2 |