Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

Egg White Ovalbumin Purified Dialyzed Lyophilized

IEGGOVAPF100MG each
EUR 97
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized

Egg White Ovalbumin Purified Dialyzed Lyophilized

IEGGOVAPF1GM each
EUR 408
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized

Hyclone Dialyzed Fetal Bovine Serum US Origin 50 mL (SH30079.01) - EACH

HYC43 EACH
EUR 116.1

Hyclone Dialyzed Fetal Bovine Serum US Origin 100 mL (SH30079.02) - EACH

HYC45 EACH
EUR 195.75

Hyclone Dialyzed Fetal Bovine Serum US Origin 500 mL (SH30079.03) - EACH

HYC47 EACH
EUR 816.75

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0500 500 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0500 500 ml Ask for price

Hyclone Dialyzed Fetal Bovine Serum US Origin Irradiated 500 mL (SH30079.03IR) - EACH

HYC50 EACH
EUR 892.35

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 50 mL (SH30079.01HI) - EACH

HYC44 EACH
EUR 137.7

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 100 mL (SH30079.02HI) - EACH

HYC46 EACH
EUR 218.7

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 500 mL (SH30079.03HI) - EACH

HYC48 EACH
EUR 868.05

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0500 500 ml Ask for price

DiaEasy? Dialyzer (800 µl) MWCO 3.5 kDa

K1018-25 each
EUR 288

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa

K1019-10 each
EUR 164.4

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa

K1019-25 each
EUR 288

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-10 each
EUR 138

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-100 each
EUR 574.8

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-25 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa

K1021-10 each
EUR 138

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa

K1021-25 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa

K1022-10 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa

K1022-25 each
EUR 418.8

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-10 each
EUR 216

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa

K1001-100 each
EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa

K1001-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa

K1002-100 each
EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa

K1002-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa

K1003-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa

K1003-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa

K1004-100 each
EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa

K1004-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa

K1005-100 each
EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa

K1005-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa

K1006-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa

K1006-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa

K1007-10 each
EUR 216

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa

K1007-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa

K1008-10 each
EUR 216

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa

K1008-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 1 kDa

K1009-25 each
EUR 914.4

DiaEasy? Dialyzer (15 ml) MWCO 1 kDa

K1010-25 each
EUR 914.4

DiaEasy? Dialyzer (10 ml) MWCO 1 kDa

K1011-25 each
EUR 914.4

DiaEasy? Dialyzer (3 ml) MWCO 3.5 kDa

K1012-25 each
EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 6-8 kDa

K1013-25 each
EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 12-14 kDa

K1014-25 each
EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 25 kDa

K1015-25 each
EUR 588

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-10 each
EUR 301.2

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-100 each
EUR 1776

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-25 each
EUR 588

DiaEasy? Dialyzer (800 µl) MWCO 1 kDa

K1017-25 each
EUR 579.6

DiaEasy? Dialyzer (250 µl) Floating racks

1020-10 each
EUR 124.8

DiaEasy? Dialyzer (250 µl) Floating racks

1020-5 each
EUR 105.6

DiaEasy? Dialyzer (800 µl) Floating racks

1018-10 each
EUR 124.8

DiaEasy? Dialyzer (800 µl) Floating racks

1018-5 each
EUR 105.6

DiaEasy? Dialyzer (3 ml) Floating racks

1016-10 each
EUR 170.4

DiaEasy? Dialyzer (3 ml) Floating racks

1016-5 each
EUR 130.8

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks

1000-10 each
EUR 164.4

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks

1000-5 each
EUR 124.8

DiaEasy? Dialyzer (250 µl) Supporting trays

1028-10 each
EUR 124.8

DiaEasy? Dialyzer (250 µl) Supporting trays

1028-5 each
EUR 105.6

DiaEasy? Dialyzer (3 ml) Supporting trays

1017-10 each
EUR 157.2

DiaEasy? Dialyzer (3 ml) Supporting trays

1017-5 each
EUR 117.6

DiaEasy? Dialyzer (800 µl) Supporting trays

1019-10 each
EUR 124.8

DiaEasy? Dialyzer (800 µl) Supporting trays

1019-5 each
EUR 105.6

FBS (PREMIUM)

35-015-CV 500 mL/pk
EUR 667.2
Description: Serum; Serum

FBS Replacement

0454-50 50 ml
EUR 97.2

FBS Replacement

0454-500 500 ml
EUR 248.4

FBS (US Origin)

C0013-12 RT 500 mL Bottle
EUR 595

FBS Liquid Media

88-NB05 100 ml
EUR 196.8
Description: Fetal Bovine Serum (US origin)

FBS, Hepatocyte Optimized

F0692-050 500ml Ask for price

FBS, Melanocyte Optimized

F0695-050 500ml Ask for price

Recombinant Fibrosin (FBS)

RPU51034-100ug 100ug
EUR 451

Recombinant Fibrosin (FBS)

RPU51034-1mg 1mg
EUR 1998.1

Recombinant Fibrosin (FBS)

RPU51034-50ug 50ug
EUR 361.9

Recombinant Fibrosin (FBS)

RPC473Hu01 10ug
EUR 146

Recombinant Fibrosin (FBS)

4-RPC473Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)

RPC473Mu01 10ug
EUR 158

Recombinant Fibrosin (FBS)

4-RPC473Mu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)

RPU51444-100ug 100ug
EUR 488.4

Recombinant Fibrosin (FBS)

RPU51444-1mg 1mg
EUR 2161.9

Recombinant Fibrosin (FBS)

RPU51444-50ug 50ug
EUR 391.6

FBS, Transfection Optimized

F0640-050 500ml
EUR 902.4

FBS, Keratinocyte Optimized

F0694-050 500ml Ask for price

Refeed Medium 5% FBS

10-170100 100 mL Ask for price
Description: used with most cell cultures for detection of viruses other than influenza

Refeed Medium 5% FBS

10-170500 500 mL Ask for price
Description: used with most cell cultures for detection of viruses other than influenza

FBS - Fetal Bovine Serum

FBS001 500 ml
EUR 654

FBS Alternative (Xeno-free)

P766-50 - Ask for price

FBS Alternative (Xeno-free)

P766-500 - Ask for price

FBS (PREMIUM, HEAT INACTIVATED)

35-016-CV 500 mL/pk
EUR 678
Description: Serum; Serum

FBS, Fibroblasts Optimized I

F0691-050 500ml Ask for price

Fibrosin (FBS) Polyclonal Antibody

CAU24231-100ul 100ul
EUR 241.9

Fibrosin (FBS) Polyclonal Antibody

CAU24231-200ul 200ul
EUR 302.4

Fibrosin (FBS) Polyclonal Antibody

CAU24232-100ul 100ul
EUR 235.2

Fibrosin (FBS) Polyclonal Antibody

CAU24232-200ul 200ul
EUR 294

Fetal Bovine Serum (FBS) [500 ml]

ABP-MED-FBS0500 500ml Ask for price

FBS Opti-Gold, US Origin

F0900-050 500ml
EUR 675.6

MEM Complete Medium (10%FBS)

PM150411B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

MEM Complete Medium (20%FBS)

PM150411C-125mL4 125 mL×4
EUR 158
Description: Complete Growth Medium

ELISA Kit for Fibrosin (FBS)

SEC473Mu 96Т
EUR 720

MEMα Complete Medium (10%FBS)

PM150421B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

MEMα Complete Medium (20%FBS)

PM150421C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

IMDM Complete Medium (10%FBS)

PM150510B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

IMDM Complete Medium (20%FBS)

PM150510C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

M199 Complete Medium (10%FBS)

PM150610B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

M199 Complete Medium (20%FBS)

PM150610C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

Human Fibrosin(FBS)ELISA Kit

QY-E00902 96T
EUR 433.2

100ML FBS - Sterile - Filtered - 100ML

SLS1166 100ML
EUR 102.6

FBS - Preferred Fetal Bovine Serum

FBS007 each
EUR 270

Cell Culture Freezing Medium (FBS)

cAP-22 50ml
EUR 108.9

FBS, Endothelial Cell Optimized I

F0670-050 500ml Ask for price

FBS, Endothelial Cell Optimized II

F0672-050 500ml Ask for price

FBS, Epithelical Cell Optimized I

F0680-050 500ml Ask for price

FBS, Epithelical Cell Optimized II

F0682-050 500ml Ask for price

Polyclonal Antibody to Fibrosin (FBS)

PAC473Hu01 100ul
EUR 245

Polyclonal Antibody to Fibrosin (FBS)

PAC473Mu01 100ul
EUR 252

Fibrosin (FBS) Polyclonal Antibody (Mouse)

4-PAC473Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS)

Exosome-depleted FBS Media Supplement

EXO-FBS-250A-1 250 ml
EUR 837

Exosome-depleted FBS Media Supplement

EXO-FBS-50A-1 50 ml
EUR 193

Fetal Bovine Serum (FBS) [50 ml]

ABP-MED-FBS0050 50ml Ask for price

DMEM/F12 Complete Medium (10%FBS)

PM150312B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

DMEM/F12 Complete Medium (20%FBS)

PM150312C-125mL4 125 mL×4
EUR 158
Description: Complete Growth Medium

McCoy's 5A Complete Medium (10%FBS)

PM150710B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

McCoy's 5A Complete Medium (20%FBS)

PM150710C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

FBS - Tet-Free Fetal Bovine Serum

FBS002-T each
EUR 415.8

FBS - Fetal Bovine Serum USDA Origin

FBS002 500 mL
EUR 574.8

RPMI-1640 Complete Medium (10%FBS)

PM150110B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

RPMI-1640 Complete Medium (20%FBS)

PM150110C-125mL4 125 mL×4
EUR 158
Description: Complete Growth Medium

FBS - Female Only Fetal Bovine Serum

FBS001-F each
EUR 581.4

FBS - Exosome Free Fetal Bovine Serum

FBS002-X each
EUR 120.6

FBS - Exosome Free Fetal Bovine Serum

FBS002-X-A each
EUR 601.2

FBS - Lipid Depleted Fetal Bovine Serum

FBS005-L each
EUR 558

FBS Ultra Low IgG, < 5 μg/ml

F1900-050 500ml
EUR 1113.6

100ML FBS - Sterile - Heat Inactivated - 100ML

SLS1168 100ML
EUR 139.05

FBS - Charcoal Stripped Fetal Bovine Serum

FBS005-C each
EUR 585

Fibrosin (FBS) Polyclonal Antibody (Mouse), PE

4-PAC473Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC

4-PAC473Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3

4-PAC473Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP

4-PAC473Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC

4-PAC473Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse)

4-PAC473Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS)

Ham's F-12 Complete Medium (10%FBS)

PM150810B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

Ham's F-12 Complete Medium (20%FBS)

PM150810C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

Ham's F-10 Complete Medium (10%FBS)

PM151110B-125mL4 125 mL×4
EUR 108
Description: Complete Growth Medium

Ham's F-10 Complete Medium (20%FBS)

PM151110C-125mL4 125 mL×4
EUR 168
Description: Complete Growth Medium

FBS Opti-Gold, US Origin, Low IgG

F0970-050 500ml Ask for price