retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.
Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.
ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.
This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.
FBS Replacement |
0454-50 |
AthenaES |
50 ml |
EUR 81 |
FBS Replacement |
0454-500 |
AthenaES |
500 ml |
EUR 207 |
Recombinant Fibrosin (FBS) |
4-RPC473Hu01 |
Cloud-Clone |
-
EUR 427.94
-
EUR 217.00
-
EUR 1329.76
-
EUR 509.92
-
EUR 919.84
-
EUR 349.00
-
EUR 3174.40
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Fibrosin expressed in: E.coli |
Recombinant Fibrosin (FBS) |
4-RPC473Mu01 |
Cloud-Clone |
-
EUR 454.82
-
EUR 224.00
-
EUR 1430.56
-
EUR 543.52
-
EUR 987.04
-
EUR 367.00
-
EUR 3426.40
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Mouse Fibrosin expressed in: E.coli |
FBS, Transfection Optimized |
F0640-050 |
GenDepot |
500ml |
EUR 752 |
FBS, Hepatocyte Optimized |
F0692-050 |
GenDepot |
500ml |
Ask for price |
FBS, Keratinocyte Optimized |
F0694-050 |
GenDepot |
500ml |
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FBS, Melanocyte Optimized |
F0695-050 |
GenDepot |
500ml |
Ask for price |
FBS Liquid Media |
88-NB05 |
Fitzgerald |
100 ml |
EUR 164 |
Description: Fetal Bovine Serum (US origin) |
FBS Liquid Media |
88-NB06 |
Fitzgerald |
500 ml |
EUR 651 |
Description: FBS Liquid Media (Heat Inactivated) |
FBS, Fibroblasts Optimized I |
F0691-050 |
GenDepot |
500ml |
Ask for price |
FBS - Fetal Bovine Serum |
FBS001 |
Neuromics |
500 ml |
EUR 545 |
FBS Alternative (Xeno-free) |
P766-50 |
101Bio |
- |
Ask for price |
FBS Alternative (Xeno-free) |
P766-500 |
101Bio |
- |
Ask for price |
FBS (PREMIUM, HEAT INACTIVATED) |
35-016-CV |
CORNING |
500 mL/pk |
EUR 565 |
Description: Serum; Serum |
Fetal Bovine Serum, Premium, US Origin, Dialyzed |
F0602-050 |
GenDepot |
500ml |
EUR 1063 |
500 ML FETAL BOVINE SERUM, PREMIUM (DIALYZED) |
35-071-CV |
CORNING |
500 mL/pk |
EUR 925 |
Description: Serum; Serum |
Fibrosin (FBS) Polyclonal Antibody (Mouse) |
4-PAC473Mu01 |
Cloud-Clone |
-
EUR 251.00
-
EUR 2576.00
-
EUR 640.00
-
EUR 316.00
-
EUR 215.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS) |
FBS, Endothelial Cell Optimized I |
F0670-050 |
GenDepot |
500ml |
Ask for price |
FBS, Endothelial Cell Optimized II |
F0672-050 |
GenDepot |
500ml |
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FBS, Epithelical Cell Optimized I |
F0680-050 |
GenDepot |
500ml |
Ask for price |
FBS, Epithelical Cell Optimized II |
F0682-050 |
GenDepot |
500ml |
Ask for price |
FBS Opti-Gold, US Origin |
F0900-050 |
GenDepot |
500ml |
EUR 563 |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse) |
4-PAC473Hu01 |
Cloud-Clone |
-
EUR 247.00
-
EUR 2510.00
-
EUR 625.00
-
EUR 310.00
-
EUR 214.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS) |
Fibrosin (FBS) Polyclonal Antibody (Mouse), APC |
4-PAC473Mu01-APC |
Cloud-Clone |
-
EUR 351.00
-
EUR 3365.00
-
EUR 935.00
-
EUR 449.00
-
EUR 222.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated |
4-PAC473Mu01-Biotin |
Cloud-Clone |
-
EUR 316.00
-
EUR 2526.00
-
EUR 744.00
-
EUR 387.00
-
EUR 221.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3 |
4-PAC473Mu01-Cy3 |
Cloud-Clone |
-
EUR 427.00
-
EUR 4445.00
-
EUR 1205.00
-
EUR 557.00
-
EUR 254.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC |
4-PAC473Mu01-FITC |
Cloud-Clone |
-
EUR 301.00
-
EUR 2712.00
-
EUR 768.00
-
EUR 379.00
-
EUR 197.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP |
4-PAC473Mu01-HRP |
Cloud-Clone |
-
EUR 321.00
-
EUR 2933.00
-
EUR 827.00
-
EUR 405.00
-
EUR 209.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), PE |
4-PAC473Mu01-PE |
Cloud-Clone |
-
EUR 301.00
-
EUR 2712.00
-
EUR 768.00
-
EUR 379.00
-
EUR 197.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE. |
FBS - Fetal Bovine Serum USDA Origin |
FBS002 |
Neuromics |
500 mL |
EUR 479 |
Fetal Bovine Serum (FBS) [50 ml] |
ABP-MED-FBS0050 |
Allele Biotech |
50ml |
Ask for price |
|
Fetal Bovine Serum (FBS) [500 ml] |
ABP-MED-FBS0500 |
Allele Biotech |
500ml |
Ask for price |
|
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC |
4-PAC473Hu01-APC |
Cloud-Clone |
-
EUR 345.00
-
EUR 3275.00
-
EUR 912.00
-
EUR 440.00
-
EUR 219.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated |
4-PAC473Hu01-Biotin |
Cloud-Clone |
-
EUR 311.00
-
EUR 2460.00
-
EUR 727.00
-
EUR 381.00
-
EUR 219.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3 |
4-PAC473Hu01-Cy3 |
Cloud-Clone |
-
EUR 419.00
-
EUR 4325.00
-
EUR 1175.00
-
EUR 545.00
-
EUR 251.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC |
4-PAC473Hu01-FITC |
Cloud-Clone |
-
EUR 296.00
-
EUR 2640.00
-
EUR 750.00
-
EUR 372.00
-
EUR 195.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP |
4-PAC473Hu01-HRP |
Cloud-Clone |
-
EUR 316.00
-
EUR 2855.00
-
EUR 807.00
-
EUR 398.00
-
EUR 206.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE |
4-PAC473Hu01-PE |
Cloud-Clone |
-
EUR 296.00
-
EUR 2640.00
-
EUR 750.00
-
EUR 372.00
-
EUR 195.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7 |
4-PAC473Mu01-APC-Cy7 |
Cloud-Clone |
-
EUR 583.00
-
EUR 6610.00
-
EUR 1750.00
-
EUR 778.00
-
EUR 324.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7. |
FBS Ultra Low IgG, < 5 μg/ml |
F1900-050 |
GenDepot |
500ml |
EUR 928 |
FBS-HI - Heat Inactivated Fetal Bovine Serum |
FBS001-HI |
Neuromics |
500 ml |
EUR 564 |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBMDY30-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBMDY30-0500 |
Equitech |
500 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBUDY30-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBUDY30-0500 |
Equitech |
500 ml |
Ask for price |
|
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7 |
4-PAC473Hu01-APC-Cy7 |
Cloud-Clone |
-
EUR 571.00
-
EUR 6430.00
-
EUR 1705.00
-
EUR 760.00
-
EUR 319.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7. |
FBS,Mouse Embryonic Stem cell and iPSC Optimized |
F0650-050 |
GenDepot |
500ml |
EUR 752 |
FBS,Human Embryonic Stem cell and iPSC Optimized |
F0660-050 |
GenDepot |
500ml |
EUR 752 |
Fetal Bovine Serum (FBS), Premium, 100% US Origin |
P760-1 |
101Bio |
- |
Ask for price |
Fetal Bovine Serum (FBS), Premium, 100% US Origin |
P760-10 |
101Bio |
- |
Ask for price |
Fetal Bovine Serum (FBS), Premium, 100% US Origin |
P760S |
101Bio |
- |
Ask for price |
Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG |
FBS11-A |
Alpha Diagnostics |
100 ul |
EUR 408 |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
SFBMDY32-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
SFBMDY32-0500 |
Equitech |
500 ml |
Ask for price |
|
Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified |
EXO-FBSHI-250A-1 |
SBI |
250 ml |
EUR 893 |
|
Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified |
EXO-FBSHI-50A-1 |
SBI |
50 ml |
EUR 255 |
|
Collagenase Type I Solution 0.25% in PBS with 20% FBS |
CA091-002 |
GenDepot |
20ml |
EUR 178 |
Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested |
P761-1 |
101Bio |
- |
Ask for price |
Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested |
P761-10 |
101Bio |
- |
Ask for price |
Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested |
P761S |
101Bio |
- |
Ask for price |
Human Anti-Fetal Bovine/Calf Serum (FBS /FCS) IgG ELISA Kit, 96 tests, Quantitative |
710-150-FBG |
Alpha Diagnostics |
1 Kit |
EUR 773 |
Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG-Agarose affinity matrix to remove fetal bovine serum |
FBS12-AS |
Alpha Diagnostics |
2 ml |
EUR 469 |