retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.
Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.
ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.
This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.
FBS (PREMIUM) |
35-015-CV |
CORNING |
500 mL/pk |
EUR 667.2 |
Description: Serum; Serum |
FBS Replacement |
0454-50 |
AthenaES |
50 ml |
EUR 97.2 |
FBS Replacement |
0454-500 |
AthenaES |
500 ml |
EUR 248.4 |
FBS Liquid Media |
88-NB05 |
Fitzgerald |
100 ml |
EUR 196.8 |
Description: Fetal Bovine Serum (US origin) |
FBS Liquid Media |
88-NB06 |
Fitzgerald |
500 ml |
EUR 781.2 |
Description: FBS Liquid Media (Heat Inactivated) |
FBS, Transfection Optimized |
F0640-050 |
GenDepot |
500ml |
EUR 902.4 |
FBS, Hepatocyte Optimized |
F0692-050 |
GenDepot |
500ml |
Ask for price |
FBS, Keratinocyte Optimized |
F0694-050 |
GenDepot |
500ml |
Ask for price |
FBS, Melanocyte Optimized |
F0695-050 |
GenDepot |
500ml |
Ask for price |
Recombinant Fibrosin (FBS) |
4-RPC473Hu01 |
Cloud-Clone |
-
EUR 513.53
-
EUR 260.40
-
EUR 1595.71
-
EUR 611.90
-
EUR 1103.81
-
EUR 418.80
-
EUR 3809.28
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Fibrosin expressed in: E.coli |
Recombinant Fibrosin (FBS) |
4-RPC473Mu01 |
Cloud-Clone |
-
EUR 545.78
-
EUR 268.80
-
EUR 1716.67
-
EUR 652.22
-
EUR 1184.45
-
EUR 440.40
-
EUR 4111.68
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Mouse Fibrosin expressed in: E.coli |
FBS (PREMIUM, HEAT INACTIVATED) |
35-016-CV |
CORNING |
500 mL/pk |
EUR 678 |
Description: Serum; Serum |
FBS, Fibroblasts Optimized I |
F0691-050 |
GenDepot |
500ml |
Ask for price |
FBS - Fetal Bovine Serum |
FBS001 |
Neuromics |
500 ml |
EUR 654 |
Fibrosin (FBS) Polyclonal Antibody (Mouse) |
4-PAC473Mu01 |
Cloud-Clone |
-
EUR 301.20
-
EUR 3091.20
-
EUR 768.00
-
EUR 379.20
-
EUR 258.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS) |
FBS, Endothelial Cell Optimized I |
F0670-050 |
GenDepot |
500ml |
Ask for price |
FBS, Endothelial Cell Optimized II |
F0672-050 |
GenDepot |
500ml |
Ask for price |
FBS, Epithelical Cell Optimized I |
F0680-050 |
GenDepot |
500ml |
Ask for price |
FBS, Epithelical Cell Optimized II |
F0682-050 |
GenDepot |
500ml |
Ask for price |
FBS Opti-Gold, US Origin |
F0900-050 |
GenDepot |
500ml |
EUR 675.6 |
500 ML FETAL BOVINE SERUM, PREMIUM (DIALYZED) |
35-071-CV |
CORNING |
500 mL/pk |
EUR 1110 |
Description: Serum; Serum |
Fetal Bovine Serum, Premium, US Origin, Dialyzed |
F0602-050 |
GenDepot |
500ml |
EUR 1275.6 |
Fetal Bovine Serum (FBS) [50 ml] |
ABP-MED-FBS0050 |
Allele Biotech |
50ml |
Ask for price |
|
Fetal Bovine Serum (FBS) [500 ml] |
ABP-MED-FBS0500 |
Allele Biotech |
500ml |
Ask for price |
|
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse) |
4-PAC473Hu01 |
Cloud-Clone |
-
EUR 296.40
-
EUR 3012.00
-
EUR 750.00
-
EUR 372.00
-
EUR 256.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS) |
Fibrosin (FBS) Polyclonal Antibody (Mouse), APC |
4-PAC473Mu01-APC |
Cloud-Clone |
-
EUR 421.20
-
EUR 4038.00
-
EUR 1122.00
-
EUR 538.80
-
EUR 266.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated |
4-PAC473Mu01-Biotin |
Cloud-Clone |
-
EUR 379.20
-
EUR 3031.20
-
EUR 892.80
-
EUR 464.40
-
EUR 265.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3 |
4-PAC473Mu01-Cy3 |
Cloud-Clone |
-
EUR 512.40
-
EUR 5334.00
-
EUR 1446.00
-
EUR 668.40
-
EUR 304.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC |
4-PAC473Mu01-FITC |
Cloud-Clone |
-
EUR 361.20
-
EUR 3254.40
-
EUR 921.60
-
EUR 454.80
-
EUR 236.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP |
4-PAC473Mu01-HRP |
Cloud-Clone |
-
EUR 385.20
-
EUR 3519.60
-
EUR 992.40
-
EUR 486.00
-
EUR 250.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), PE |
4-PAC473Mu01-PE |
Cloud-Clone |
-
EUR 361.20
-
EUR 3254.40
-
EUR 921.60
-
EUR 454.80
-
EUR 236.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE. |
FBS - Fetal Bovine Serum USDA Origin |
FBS002 |
Neuromics |
500 mL |
EUR 574.8 |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC |
4-PAC473Hu01-APC |
Cloud-Clone |
-
EUR 414.00
-
EUR 3930.00
-
EUR 1094.40
-
EUR 528.00
-
EUR 262.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated |
4-PAC473Hu01-Biotin |
Cloud-Clone |
-
EUR 373.20
-
EUR 2952.00
-
EUR 872.40
-
EUR 457.20
-
EUR 262.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3 |
4-PAC473Hu01-Cy3 |
Cloud-Clone |
-
EUR 502.80
-
EUR 5190.00
-
EUR 1410.00
-
EUR 654.00
-
EUR 301.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC |
4-PAC473Hu01-FITC |
Cloud-Clone |
-
EUR 355.20
-
EUR 3168.00
-
EUR 900.00
-
EUR 446.40
-
EUR 234.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP |
4-PAC473Hu01-HRP |
Cloud-Clone |
-
EUR 379.20
-
EUR 3426.00
-
EUR 968.40
-
EUR 477.60
-
EUR 247.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE |
4-PAC473Hu01-PE |
Cloud-Clone |
-
EUR 355.20
-
EUR 3168.00
-
EUR 900.00
-
EUR 446.40
-
EUR 234.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7 |
4-PAC473Mu01-APC-Cy7 |
Cloud-Clone |
-
EUR 699.60
-
EUR 7932.00
-
EUR 2100.00
-
EUR 933.60
-
EUR 388.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7. |
FBS Ultra Low IgG, < 5 μg/ml |
F1900-050 |
GenDepot |
500ml |
EUR 1113.6 |
FBS-HI - Heat Inactivated Fetal Bovine Serum |
FBS001-HI |
Neuromics |
500 ml |
EUR 676.8 |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBMDY30-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBMDY30-0500 |
Equitech |
500 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBUDY30-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
SFBUDY30-0500 |
Equitech |
500 ml |
Ask for price |
|
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7 |
4-PAC473Hu01-APC-Cy7 |
Cloud-Clone |
-
EUR 685.20
-
EUR 7716.00
-
EUR 2046.00
-
EUR 912.00
-
EUR 382.80
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7. |
FBS,Mouse Embryonic Stem cell and iPSC Optimized |
F0650-050 |
GenDepot |
500ml |
EUR 902.4 |
FBS,Human Embryonic Stem cell and iPSC Optimized |
F0660-050 |
GenDepot |
500ml |
EUR 902.4 |
Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG |
FBS11-A |
Alpha Diagnostics |
100 ul |
EUR 489.6 |
Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified |
EXO-FBSHI-250A-1 |
SBI |
250 ml |
EUR 1071.6 |
|
Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified |
EXO-FBSHI-50A-1 |
SBI |
50 ml |
EUR 306 |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
SFBMDY32-0100 |
Equitech |
100 ml |
Ask for price |
|
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
SFBMDY32-0500 |
Equitech |
500 ml |
Ask for price |
|
Collagenase Type I Solution 0.25% in PBS with 20% FBS |
CA091-002 |
GenDepot |
20ml |
EUR 213.6 |
Human Anti-Fetal Bovine/Calf Serum (FBS /FCS) IgG ELISA Kit, 96 tests, Quantitative |
710-150-FBG |
Alpha Diagnostics |
1 Kit |
EUR 927.6 |
Exo-Check Exosome Antibody Array |
322-EXO-FBS-50A-1 |
Gentaur Genprice |
100 µg |
EUR 469.2 |
Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG-Agarose affinity matrix to remove fetal bovine serum |
FBS12-AS |
Alpha Diagnostics |
2 ml |
EUR 562.8 |