Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

FBS (PREMIUM)

35-015-CV 500 mL/pk
EUR 667.2
Description: Serum; Serum

FBS Replacement

0454-50 50 ml
EUR 97.2

FBS Replacement

0454-500 500 ml
EUR 248.4

FBS Liquid Media

88-NB05 100 ml
EUR 196.8
Description: Fetal Bovine Serum (US origin)

FBS Liquid Media

88-NB06 500 ml
EUR 781.2
Description: FBS Liquid Media (Heat Inactivated)

FBS, Transfection Optimized

F0640-050 500ml
EUR 902.4

FBS, Hepatocyte Optimized

F0692-050 500ml Ask for price

FBS, Keratinocyte Optimized

F0694-050 500ml Ask for price

FBS, Melanocyte Optimized

F0695-050 500ml Ask for price

Recombinant Fibrosin (FBS)

4-RPC473Hu01
  • EUR 513.53
  • EUR 260.40
  • EUR 1595.71
  • EUR 611.90
  • EUR 1103.81
  • EUR 418.80
  • EUR 3809.28
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)

4-RPC473Mu01
  • EUR 545.78
  • EUR 268.80
  • EUR 1716.67
  • EUR 652.22
  • EUR 1184.45
  • EUR 440.40
  • EUR 4111.68
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

FBS (PREMIUM, HEAT INACTIVATED)

35-016-CV 500 mL/pk
EUR 678
Description: Serum; Serum

FBS, Fibroblasts Optimized I

F0691-050 500ml Ask for price

FBS - Fetal Bovine Serum

FBS001 500 ml
EUR 654

FBS Alternative (Xeno-free)

P766-50 - Ask for price

FBS Alternative (Xeno-free)

P766-500 - Ask for price

100ML FBS - Sterile - Filtered

SLS1166 100ML
EUR 70.68

Fibrosin (FBS) Polyclonal Antibody (Mouse)

4-PAC473Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS)

FBS, Endothelial Cell Optimized I

F0670-050 500ml Ask for price

FBS, Endothelial Cell Optimized II

F0672-050 500ml Ask for price

FBS, Epithelical Cell Optimized I

F0680-050 500ml Ask for price

FBS, Epithelical Cell Optimized II

F0682-050 500ml Ask for price

FBS Opti-Gold, US Origin

F0900-050 500ml
EUR 675.6

Human Fibrosin(FBS)ELISA Kit

QY-E00902 96T
EUR 433.2

100ML FBS - Sterile - Heat Inactivated

SLS1168 100ML
EUR 102.6

500 ML FETAL BOVINE SERUM, PREMIUM (DIALYZED)

35-071-CV 500 mL/pk
EUR 1110
Description: Serum; Serum

Fetal Bovine Serum, Premium, US Origin, Dialyzed

F0602-050 500ml
EUR 1275.6

Fetal Bovine Serum (FBS) [50 ml]

ABP-MED-FBS0050 50ml Ask for price

Fetal Bovine Serum (FBS) [500 ml]

ABP-MED-FBS0500 500ml Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse)

4-PAC473Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS)

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC

4-PAC473Mu01-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated

4-PAC473Mu01-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3

4-PAC473Mu01-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC

4-PAC473Mu01-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP

4-PAC473Mu01-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), PE

4-PAC473Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE.

FBS - Fetal Bovine Serum USDA Origin

FBS002 500 mL
EUR 574.8

South American FBS Serum 500ml Bottles

35-079-CV 500ML
EUR 391.02

500ML FBS EU Grade Origin: Brazil

SLS1108 500ML
EUR 273.6

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC

4-PAC473Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated

4-PAC473Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3

4-PAC473Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC

4-PAC473Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP

4-PAC473Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE

4-PAC473Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC473Mu01-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS Ultra Low IgG, < 5 μg/ml

F1900-050 500ml
EUR 1113.6

FBS-HI - Heat Inactivated Fetal Bovine Serum

FBS001-HI 500 ml
EUR 676.8

Fetal Bovine Serum (FBS) proteins for ELISA

FBS15-N-1 1 ml
EUR 270

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0500 500 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0500 500 ml Ask for price

Hyclone Dialyzed Fetal Bovine Serum US Origin 50 mL (SH30079.01)

HYC43 EACH
EUR 92.34

Hyclone Dialyzed Fetal Bovine Serum US Origin 100 mL (SH30079.02)

HYC45 EACH
EUR 157.32

Hyclone Dialyzed Fetal Bovine Serum US Origin 500 mL (SH30079.03)

HYC47 EACH
EUR 656.64

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7

4-PAC473Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS,Mouse Embryonic Stem cell and iPSC Optimized

F0650-050 500ml
EUR 902.4

FBS,Human Embryonic Stem cell and iPSC Optimized

F0660-050 500ml
EUR 902.4

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG

FBS11-A 100 ul
EUR 489.6

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-1 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-10 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760S - Ask for price

South American FBS Serum Heat Inactivated 500ml Bottles

35-089-CV 500ML
EUR 399

Hyclone Dialyzed Fetal Bovine Serum US Origin Irradiated 500 mL (SH30079.03IR)

HYC50 EACH
EUR 694.26

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified      

EXO-FBSHI-250A-1 250 ml
EUR 1071.6

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified      

EXO-FBSHI-50A-1 50 ml
EUR 306

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0500 500 ml Ask for price

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 50 mL (SH30079.01HI)

HYC44 EACH
EUR 108.3

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 100 mL (SH30079.02HI)

HYC46 EACH
EUR 173.28

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 500 mL (SH30079.03HI)

HYC48 EACH
EUR 674.88

Collagenase Type I Solution 0.25% in PBS with 20% FBS

CA091-002 20ml
EUR 213.6

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761-1 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761-10 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761S - Ask for price

500ML LSG Fetal Bovine Serum (FBS) - Sterile Filtered US Origin

SLS1154 500ML
EUR 978.12

Hyclone Tetracycline Screened FBS US Origin Heat Inactivated 500 mL (SH30070.03TH)

HYC33 EACH
EUR 1026

Hyclone Characterized FBS US Origin Irradiated Heat Inactiv 500 mL (SH30071.03IH)

HYC41 EACH
EUR 611.04

500ML LSG Fetal Bovine Serum (FBS) -Sterile Filtered - Heat Inactivated 500ml

SLS1150 500ML
EUR 296.4

500ML LSG Fetal Bovine Serum (FBS) - Sterile Filtered - Gamma Irradiated 500ml

SLS1152 500ML
EUR 444.6

Hyclone Charcoal/Dextran Treated FBS US Origin Heat Inactiv 100 mL (SH30068.02HI)

HYC10 EACH
EUR 173.28

Hyclone Char/Dext Treated FBS US Origin Heat Inactivated 500 mL (SH30068.03HI)

HYC12 EACH
EUR 674.88

Hyclone Human Mesenchymal Stem Cell Screened FBS US Origin 500 mL (SH30070.03M)

HYC31 EACH
EUR 1010.04

Hyclone Standard FBS US Origin Irradiated and Heat Inactiv 500 mL (SH30088.03IH)

HYC60 EACH
EUR 506.16

Hyclone Charcoal/Dextran Treated FBS US Origin Heat Inactiv 50 mL (SH30068.01HI)

HYC8 EACH
EUR 108.3

Hyclone Research Grade FBS S-American Origin Heat Inactiv 500 mL (SV30160.03HI)

HYC86 EACH
EUR 258.78

500ML LSG Fetal Bovine Serum (FBS) - Sterile Filtered - Heat Inactivated US Origin

SLS1156 500ML
EUR 957.6

Hyclone Super Low IgG FBS US Origin Irradiated Heat Inactiv 500 mL (SH30898.03IH)

HYC77 EACH
EUR 745.56

Human Anti-Fetal Bovine/Calf Serum (FBS /FCS) IgG ELISA Kit, 96 tests, Quantitative

710-150-FBG 1 Kit
EUR 927.6

Exo-Check Exosome Antibody Array

322-EXO-FBS-50A-1 100 µg
EUR 469.2

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG-Agarose affinity matrix to remove fetal bovine serum

FBS12-AS 2 ml
EUR 562.8