retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.
Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.
ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.
This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.
Egg White Ovalbumin Purified Dialyzed Lyophilized |
|||
IEGGOVAPF100MG | Innovative research | each | EUR 97 |
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized |
Egg White Ovalbumin Purified Dialyzed Lyophilized |
|||
IEGGOVAPF1GM | Innovative research | each | EUR 408 |
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized |
Hyclone Dialyzed Fetal Bovine Serum US Origin 50 mL (SH30079.01) - EACH |
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HYC43 | Scientific Laboratory Supplies | EACH | EUR 116.1 |
Hyclone Dialyzed Fetal Bovine Serum US Origin 100 mL (SH30079.02) - EACH |
|||
HYC45 | Scientific Laboratory Supplies | EACH | EUR 195.75 |
Hyclone Dialyzed Fetal Bovine Serum US Origin 500 mL (SH30079.03) - EACH |
|||
HYC47 | Scientific Laboratory Supplies | EACH | EUR 816.75 |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
|||
SFBMDY30-0100 | Equitech | 100 ml | Ask for price |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
|||
SFBMDY30-0500 | Equitech | 500 ml | Ask for price |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
|||
SFBUDY30-0100 | Equitech | 100 ml | Ask for price |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered |
|||
SFBUDY30-0500 | Equitech | 500 ml | Ask for price |
Hyclone Dialyzed Fetal Bovine Serum US Origin Irradiated 500 mL (SH30079.03IR) - EACH |
|||
HYC50 | Scientific Laboratory Supplies | EACH | EUR 892.35 |
Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 50 mL (SH30079.01HI) - EACH |
|||
HYC44 | Scientific Laboratory Supplies | EACH | EUR 137.7 |
Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 100 mL (SH30079.02HI) - EACH |
|||
HYC46 | Scientific Laboratory Supplies | EACH | EUR 218.7 |
Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 500 mL (SH30079.03HI) - EACH |
|||
HYC48 | Scientific Laboratory Supplies | EACH | EUR 868.05 |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
|||
SFBMDY32-0100 | Equitech | 100 ml | Ask for price |
Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated |
|||
SFBMDY32-0500 | Equitech | 500 ml | Ask for price |
DiaEasy? Dialyzer (800 µl) MWCO 3.5 kDa |
|||
K1018-25 | Biovision | each | EUR 288 |
DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa |
|||
K1019-10 | Biovision | each | EUR 164.4 |
DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa |
|||
K1019-25 | Biovision | each | EUR 288 |
DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa |
|||
K1020-10 | Biovision | each | EUR 138 |
DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa |
|||
K1020-100 | Biovision | each | EUR 574.8 |
DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa |
|||
K1020-25 | Biovision | each | EUR 235.2 |
DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa |
|||
K1021-10 | Biovision | each | EUR 138 |
DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa |
|||
K1021-25 | Biovision | each | EUR 235.2 |
DiaEasy? Dialyzer (250 µl) MWCO 25 kDa |
|||
K1022-10 | Biovision | each | EUR 235.2 |
DiaEasy? Dialyzer (250 µl) MWCO 25 kDa |
|||
K1022-25 | Biovision | each | EUR 418.8 |
DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa |
|||
K1000-10 | Biovision | each | EUR 216 |
DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa |
|||
K1000-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa |
|||
K1000-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa |
|||
K1001-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa |
|||
K1001-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa |
|||
K1002-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa |
|||
K1002-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa |
|||
K1003-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa |
|||
K1003-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa |
|||
K1004-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa |
|||
K1004-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa |
|||
K1005-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa |
|||
K1005-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa |
|||
K1006-100 | Biovision | each | EUR 1227.6 |
DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa |
|||
K1006-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa |
|||
K1007-10 | Biovision | each | EUR 216 |
DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa |
|||
K1007-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa |
|||
K1008-10 | Biovision | each | EUR 216 |
DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa |
|||
K1008-25 | Biovision | each | EUR 411.6 |
DiaEasy? Dialyzer (20 ml) MWCO 1 kDa |
|||
K1009-25 | Biovision | each | EUR 914.4 |
DiaEasy? Dialyzer (15 ml) MWCO 1 kDa |
|||
K1010-25 | Biovision | each | EUR 914.4 |
DiaEasy? Dialyzer (10 ml) MWCO 1 kDa |
|||
K1011-25 | Biovision | each | EUR 914.4 |
DiaEasy? Dialyzer (3 ml) MWCO 3.5 kDa |
|||
K1012-25 | Biovision | each | EUR 346.8 |
DiaEasy? Dialyzer (3 ml) MWCO 6-8 kDa |
|||
K1013-25 | Biovision | each | EUR 346.8 |
DiaEasy? Dialyzer (3 ml) MWCO 12-14 kDa |
|||
K1014-25 | Biovision | each | EUR 346.8 |
DiaEasy? Dialyzer (3 ml) MWCO 25 kDa |
|||
K1015-25 | Biovision | each | EUR 588 |
DiaEasy? Dialyzer (3 ml) MWCO 50 kDa |
|||
K1016-10 | Biovision | each | EUR 301.2 |
DiaEasy? Dialyzer (3 ml) MWCO 50 kDa |
|||
K1016-100 | Biovision | each | EUR 1776 |
DiaEasy? Dialyzer (3 ml) MWCO 50 kDa |
|||
K1016-25 | Biovision | each | EUR 588 |
DiaEasy? Dialyzer (800 µl) MWCO 1 kDa |
|||
K1017-25 | Biovision | each | EUR 579.6 |
DiaEasy? Dialyzer (250 µl) Floating racks |
|||
1020-10 | Biovision | each | EUR 124.8 |
DiaEasy? Dialyzer (250 µl) Floating racks |
|||
1020-5 | Biovision | each | EUR 105.6 |
DiaEasy? Dialyzer (800 µl) Floating racks |
|||
1018-10 | Biovision | each | EUR 124.8 |
DiaEasy? Dialyzer (800 µl) Floating racks |
|||
1018-5 | Biovision | each | EUR 105.6 |
DiaEasy? Dialyzer (3 ml) Floating racks |
|||
1016-10 | Biovision | each | EUR 170.4 |
DiaEasy? Dialyzer (3 ml) Floating racks |
|||
1016-5 | Biovision | each | EUR 130.8 |
DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks |
|||
1000-10 | Biovision | each | EUR 164.4 |
DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks |
|||
1000-5 | Biovision | each | EUR 124.8 |
DiaEasy? Dialyzer (250 µl) Supporting trays |
|||
1028-10 | Biovision | each | EUR 124.8 |
DiaEasy? Dialyzer (250 µl) Supporting trays |
|||
1028-5 | Biovision | each | EUR 105.6 |
DiaEasy? Dialyzer (3 ml) Supporting trays |
|||
1017-10 | Biovision | each | EUR 157.2 |
DiaEasy? Dialyzer (3 ml) Supporting trays |
|||
1017-5 | Biovision | each | EUR 117.6 |
DiaEasy? Dialyzer (800 µl) Supporting trays |
|||
1019-10 | Biovision | each | EUR 124.8 |
DiaEasy? Dialyzer (800 µl) Supporting trays |
|||
1019-5 | Biovision | each | EUR 105.6 |
FBS (PREMIUM) |
|||
35-015-CV | CORNING | 500 mL/pk | EUR 667.2 |
Description: Serum; Serum |
FBS Replacement |
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0454-50 | AthenaES | 50 ml | EUR 97.2 |
FBS Replacement |
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0454-500 | AthenaES | 500 ml | EUR 248.4 |
FBS (US Origin) |
|||
C0013-12 | Addexbio | RT 500 mL Bottle | EUR 595 |
FBS Liquid Media |
|||
88-NB05 | Fitzgerald | 100 ml | EUR 196.8 |
Description: Fetal Bovine Serum (US origin) |
FBS, Hepatocyte Optimized |
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F0692-050 | GenDepot | 500ml | Ask for price |
FBS, Melanocyte Optimized |
|||
F0695-050 | GenDepot | 500ml | Ask for price |
Recombinant Fibrosin (FBS) |
|||
RPU51034-100ug | Biomatik Corporation | 100ug | EUR 451 |
Recombinant Fibrosin (FBS) |
|||
RPU51034-1mg | Biomatik Corporation | 1mg | EUR 1998.1 |
Recombinant Fibrosin (FBS) |
|||
RPU51034-50ug | Biomatik Corporation | 50ug | EUR 361.9 |
Recombinant Fibrosin (FBS) |
|||
RPC473Hu01 | Cloud-Clone | 10ug | EUR 146 |
Recombinant Fibrosin (FBS) |
|||
4-RPC473Hu01 | Cloud-Clone |
|
|
Description: Recombinant Human Fibrosin expressed in: E.coli |
Recombinant Fibrosin (FBS) |
|||
RPC473Mu01 | Cloud-Clone | 10ug | EUR 158 |
Recombinant Fibrosin (FBS) |
|||
4-RPC473Mu01 | Cloud-Clone |
|
|
Description: Recombinant Mouse Fibrosin expressed in: E.coli |
Recombinant Fibrosin (FBS) |
|||
RPU51444-100ug | Biomatik Corporation | 100ug | EUR 488.4 |
Recombinant Fibrosin (FBS) |
|||
RPU51444-1mg | Biomatik Corporation | 1mg | EUR 2161.9 |
Recombinant Fibrosin (FBS) |
|||
RPU51444-50ug | Biomatik Corporation | 50ug | EUR 391.6 |
FBS, Transfection Optimized |
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F0640-050 | GenDepot | 500ml | EUR 902.4 |
FBS, Keratinocyte Optimized |
|||
F0694-050 | GenDepot | 500ml | Ask for price |
Refeed Medium 5% FBS |
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10-170100 | Quidel | 100 mL | Ask for price |
Description: used with most cell cultures for detection of viruses other than influenza |
Refeed Medium 5% FBS |
|||
10-170500 | Quidel | 500 mL | Ask for price |
Description: used with most cell cultures for detection of viruses other than influenza |
FBS - Fetal Bovine Serum |
|||
FBS001 | Neuromics | 500 ml | EUR 654 |
FBS Alternative (Xeno-free) |
|||
P766-50 | 101Bio | - | Ask for price |
FBS Alternative (Xeno-free) |
|||
P766-500 | 101Bio | - | Ask for price |
FBS (PREMIUM, HEAT INACTIVATED) |
|||
35-016-CV | CORNING | 500 mL/pk | EUR 678 |
Description: Serum; Serum |
FBS, Fibroblasts Optimized I |
|||
F0691-050 | GenDepot | 500ml | Ask for price |
Fibrosin (FBS) Polyclonal Antibody |
|||
CAU24231-100ul | Biomatik Corporation | 100ul | EUR 241.9 |
Fibrosin (FBS) Polyclonal Antibody |
|||
CAU24231-200ul | Biomatik Corporation | 200ul | EUR 302.4 |
Fibrosin (FBS) Polyclonal Antibody |
|||
CAU24232-100ul | Biomatik Corporation | 100ul | EUR 235.2 |
Fibrosin (FBS) Polyclonal Antibody |
|||
CAU24232-200ul | Biomatik Corporation | 200ul | EUR 294 |
Fetal Bovine Serum (FBS) [500 ml] |
|||
ABP-MED-FBS0500 | Allele Biotech | 500ml | Ask for price |
FBS Opti-Gold, US Origin |
|||
F0900-050 | GenDepot | 500ml | EUR 675.6 |
MEM Complete Medium (10%FBS) |
|||
PM150411B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
MEM Complete Medium (20%FBS) |
|||
PM150411C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 158 |
Description: Complete Growth Medium |
ELISA Kit for Fibrosin (FBS) |
|||
SEC473Mu | Cloud-Clone | 96Т | EUR 720 |
MEMα Complete Medium (10%FBS) |
|||
PM150421B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
MEMα Complete Medium (20%FBS) |
|||
PM150421C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
IMDM Complete Medium (10%FBS) |
|||
PM150510B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
IMDM Complete Medium (20%FBS) |
|||
PM150510C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
M199 Complete Medium (10%FBS) |
|||
PM150610B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
M199 Complete Medium (20%FBS) |
|||
PM150610C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
Human Fibrosin(FBS)ELISA Kit |
|||
QY-E00902 | Qayee Biotechnology | 96T | EUR 433.2 |
100ML FBS - Sterile - Filtered - 100ML |
|||
SLS1166 | Scientific Laboratory Supplies | 100ML | EUR 102.6 |
FBS - Preferred Fetal Bovine Serum |
|||
FBS007 | Neuromics | each | EUR 270 |
Cell Culture Freezing Medium (FBS) |
|||
cAP-22 | Angio Proteomie | 50ml | EUR 108.9 |
FBS, Endothelial Cell Optimized I |
|||
F0670-050 | GenDepot | 500ml | Ask for price |
FBS, Endothelial Cell Optimized II |
|||
F0672-050 | GenDepot | 500ml | Ask for price |
FBS, Epithelical Cell Optimized I |
|||
F0680-050 | GenDepot | 500ml | Ask for price |
FBS, Epithelical Cell Optimized II |
|||
F0682-050 | GenDepot | 500ml | Ask for price |
Polyclonal Antibody to Fibrosin (FBS) |
|||
PAC473Hu01 | Cloud-Clone | 100ul | EUR 245 |
Polyclonal Antibody to Fibrosin (FBS) |
|||
PAC473Mu01 | Cloud-Clone | 100ul | EUR 252 |
Fibrosin (FBS) Polyclonal Antibody (Mouse) |
|||
4-PAC473Mu01 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS) |
Exosome-depleted FBS Media Supplement |
|||
EXO-FBS-250A-1 | SBI | 250 ml | EUR 837 |
Exosome-depleted FBS Media Supplement |
|||
EXO-FBS-50A-1 | SBI | 50 ml | EUR 193 |
Fetal Bovine Serum (FBS) [50 ml] |
|||
ABP-MED-FBS0050 | Allele Biotech | 50ml | Ask for price |
DMEM/F12 Complete Medium (10%FBS) |
|||
PM150312B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
DMEM/F12 Complete Medium (20%FBS) |
|||
PM150312C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 158 |
Description: Complete Growth Medium |
McCoy's 5A Complete Medium (10%FBS) |
|||
PM150710B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
McCoy's 5A Complete Medium (20%FBS) |
|||
PM150710C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
FBS - Tet-Free Fetal Bovine Serum |
|||
FBS002-T | Neuromics | each | EUR 415.8 |
FBS - Fetal Bovine Serum USDA Origin |
|||
FBS002 | Neuromics | 500 mL | EUR 574.8 |
RPMI-1640 Complete Medium (10%FBS) |
|||
PM150110B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
RPMI-1640 Complete Medium (20%FBS) |
|||
PM150110C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 158 |
Description: Complete Growth Medium |
FBS - Female Only Fetal Bovine Serum |
|||
FBS001-F | Neuromics | each | EUR 581.4 |
FBS - Exosome Free Fetal Bovine Serum |
|||
FBS002-X | Neuromics | each | EUR 120.6 |
FBS - Exosome Free Fetal Bovine Serum |
|||
FBS002-X-A | Neuromics | each | EUR 601.2 |
FBS - Lipid Depleted Fetal Bovine Serum |
|||
FBS005-L | Neuromics | each | EUR 558 |
FBS Ultra Low IgG, < 5 μg/ml |
|||
F1900-050 | GenDepot | 500ml | EUR 1113.6 |
100ML FBS - Sterile - Heat Inactivated - 100ML |
|||
SLS1168 | Scientific Laboratory Supplies | 100ML | EUR 139.05 |
FBS - Charcoal Stripped Fetal Bovine Serum |
|||
FBS005-C | Neuromics | each | EUR 585 |
Fibrosin (FBS) Polyclonal Antibody (Mouse), PE |
|||
4-PAC473Mu01-PE | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), APC |
|||
4-PAC473Mu01-APC | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3 |
|||
4-PAC473Mu01-Cy3 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP |
|||
4-PAC473Mu01-HRP | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP. |
Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC |
|||
4-PAC473Mu01-FITC | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC. |
Fibrosin (FBS) Polyclonal Antibody (Human, Mouse) |
|||
4-PAC473Hu01 | Cloud-Clone |
|
|
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS) |
Ham's F-12 Complete Medium (10%FBS) |
|||
PM150810B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
Ham's F-12 Complete Medium (20%FBS) |
|||
PM150810C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
Ham's F-10 Complete Medium (10%FBS) |
|||
PM151110B-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 108 |
Description: Complete Growth Medium |
Ham's F-10 Complete Medium (20%FBS) |
|||
PM151110C-125mL4 | Elabscience Biotech | 125 mL×4 | EUR 168 |
Description: Complete Growth Medium |
FBS Opti-Gold, US Origin, Low IgG |
|||
F0970-050 | GenDepot | 500ml | Ask for price |