Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

FBS Replacement

0454-50 50 ml
EUR 81

FBS Replacement

0454-500 500 ml
EUR 207

Recombinant Fibrosin (FBS)

4-RPC473Hu01
  • EUR 427.94
  • EUR 217.00
  • EUR 1329.76
  • EUR 509.92
  • EUR 919.84
  • EUR 349.00
  • EUR 3174.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)

4-RPC473Mu01
  • EUR 454.82
  • EUR 224.00
  • EUR 1430.56
  • EUR 543.52
  • EUR 987.04
  • EUR 367.00
  • EUR 3426.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

FBS, Transfection Optimized

F0640-050 500ml
EUR 752

FBS, Hepatocyte Optimized

F0692-050 500ml Ask for price

FBS, Keratinocyte Optimized

F0694-050 500ml Ask for price

FBS, Melanocyte Optimized

F0695-050 500ml Ask for price

FBS Liquid Media

88-NB05 100 ml
EUR 164
Description: Fetal Bovine Serum (US origin)

FBS Liquid Media

88-NB06 500 ml
EUR 651
Description: FBS Liquid Media (Heat Inactivated)

FBS, Fibroblasts Optimized I

F0691-050 500ml Ask for price

FBS - Fetal Bovine Serum

FBS001 500 ml
EUR 545

FBS Alternative (Xeno-free)

P766-50 - Ask for price

FBS Alternative (Xeno-free)

P766-500 - Ask for price

FBS (PREMIUM, HEAT INACTIVATED)

35-016-CV 500 mL/pk
EUR 565
Description: Serum; Serum

Fetal Bovine Serum, Premium, US Origin, Dialyzed

F0602-050 500ml
EUR 1063

500 ML FETAL BOVINE SERUM, PREMIUM (DIALYZED)

35-071-CV 500 mL/pk
EUR 925
Description: Serum; Serum

Fibrosin (FBS) Polyclonal Antibody (Mouse)

4-PAC473Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS)

FBS, Endothelial Cell Optimized I

F0670-050 500ml Ask for price

FBS, Endothelial Cell Optimized II

F0672-050 500ml Ask for price

FBS, Epithelical Cell Optimized I

F0680-050 500ml Ask for price

FBS, Epithelical Cell Optimized II

F0682-050 500ml Ask for price

FBS Opti-Gold, US Origin

F0900-050 500ml
EUR 563

Human Fibrosin(FBS)ELISA Kit

QY-E00902 96T
EUR 361

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse)

4-PAC473Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS)

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC

4-PAC473Mu01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated

4-PAC473Mu01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3

4-PAC473Mu01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC

4-PAC473Mu01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP

4-PAC473Mu01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), PE

4-PAC473Mu01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE.

FBS - Fetal Bovine Serum USDA Origin

FBS002 500 mL
EUR 479

Fetal Bovine Serum (FBS) [50 ml]

ABP-MED-FBS0050 50ml Ask for price

Fetal Bovine Serum (FBS) [500 ml]

ABP-MED-FBS0500 500ml Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC

4-PAC473Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated

4-PAC473Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3

4-PAC473Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC

4-PAC473Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP

4-PAC473Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE

4-PAC473Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC473Mu01-APC-Cy7
  • EUR 583.00
  • EUR 6610.00
  • EUR 1750.00
  • EUR 778.00
  • EUR 324.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS Ultra Low IgG, < 5 μg/ml

F1900-050 500ml
EUR 928

FBS-HI - Heat Inactivated Fetal Bovine Serum

FBS001-HI 500 ml
EUR 564

Fetal Bovine Serum (FBS) proteins for ELISA

FBS15-N-1 1 ml
EUR 225

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0500 500 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0500 500 ml Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7

4-PAC473Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS,Mouse Embryonic Stem cell and iPSC Optimized

F0650-050 500ml
EUR 752

FBS,Human Embryonic Stem cell and iPSC Optimized

F0660-050 500ml
EUR 752

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-1 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-10 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760S - Ask for price

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG

FBS11-A 100 ul
EUR 408

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0500 500 ml Ask for price

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified      

EXO-FBSHI-250A-1 250 ml
EUR 893

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified      

EXO-FBSHI-50A-1 50 ml
EUR 255

Collagenase Type I Solution 0.25% in PBS with 20% FBS

CA091-002 20ml
EUR 178

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761-1 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761-10 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested

P761S - Ask for price

Human Anti-Fetal Bovine/Calf Serum (FBS /FCS) IgG ELISA Kit, 96 tests, Quantitative

710-150-FBG 1 Kit
EUR 773

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG-Agarose affinity matrix to remove fetal bovine serum

FBS12-AS 2 ml
EUR 469