Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

Egg White Ovalbumin Purified Dialyzed Lyophilized
IEGGOVAPF100MG	Innovative research	each	EUR 97
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized

Egg White Ovalbumin Purified Dialyzed Lyophilized
IEGGOVAPF1GM	Innovative research	each	EUR 408
Description: Egg White Ovalbumin Purified Dialyzed Lyophilized

Egg White Ovalbumin Purified dialyzed Lyophilized
MBS136403-100mg	MyBiosource	100mg	EUR 205

Egg White Ovalbumin Purified dialyzed Lyophilized
MBS136403-1g	MyBiosource	1g	EUR 530

Egg White Ovalbumin Purified dialyzed Lyophilized
MBS136403-5x1g	MyBiosource	5x1g	EUR 2195

Hyclone Dialyzed Fetal Bovine Serum US Origin 50 mL (SH30079.01) - EACH
HYC43	Scientific Laboratory Supplies	EACH	EUR 116.1

Hyclone Dialyzed Fetal Bovine Serum US Origin 100 mL (SH30079.02) - EACH
HYC45	Scientific Laboratory Supplies	EACH	EUR 195.75

Hyclone Dialyzed Fetal Bovine Serum US Origin 500 mL (SH30079.03) - EACH
HYC47	Scientific Laboratory Supplies	EACH	EUR 816.75

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBMDY30-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBMDY30-0500	Equitech	500 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBUDY30-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBUDY30-0500	Equitech	500 ml	Ask for price

Hyclone Dialyzed Fetal Bovine Serum US Origin Irradiated 500 mL (SH30079.03IR) - EACH
HYC50	Scientific Laboratory Supplies	EACH	EUR 892.35

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 50 mL (SH30079.01HI) - EACH
HYC44	Scientific Laboratory Supplies	EACH	EUR 137.7

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 100 mL (SH30079.02HI) - EACH
HYC46	Scientific Laboratory Supplies	EACH	EUR 218.7

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 500 mL (SH30079.03HI) - EACH
HYC48	Scientific Laboratory Supplies	EACH	EUR 868.05

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated
SFBMDY32-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated
SFBMDY32-0500	Equitech	500 ml	Ask for price

FBS-Dialyzed Fetal Bovine Serum
MBS555995-500mL	MyBiosource	500mL	EUR 810

FBS-Dialyzed Fetal Bovine Serum
MBS555995-5x500mL	MyBiosource	5x500mL	EUR 3495

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa
K1000-10	Biovision	each	EUR 216

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa
K1000-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa
K1000-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa
K1001-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa
K1001-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa
K1002-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa
K1002-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa
K1003-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa
K1003-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa
K1004-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa
K1004-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa
K1005-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa
K1005-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa
K1006-100	Biovision	each	EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa
K1006-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa
K1007-10	Biovision	each	EUR 216

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa
K1007-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa
K1008-10	Biovision	each	EUR 216

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa
K1008-25	Biovision	each	EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 1 kDa
K1009-25	Biovision	each	EUR 914.4

DiaEasy? Dialyzer (15 ml) MWCO 1 kDa
K1010-25	Biovision	each	EUR 914.4

DiaEasy? Dialyzer (10 ml) MWCO 1 kDa
K1011-25	Biovision	each	EUR 914.4

DiaEasy? Dialyzer (3 ml) MWCO 3.5 kDa
K1012-25	Biovision	each	EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 6-8 kDa
K1013-25	Biovision	each	EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 12-14 kDa
K1014-25	Biovision	each	EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 25 kDa
K1015-25	Biovision	each	EUR 588

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa
K1016-10	Biovision	each	EUR 301.2

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa
K1016-100	Biovision	each	EUR 1776

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa
K1016-25	Biovision	each	EUR 588

DiaEasy? Dialyzer (800 µl) MWCO 1 kDa
K1017-25	Biovision	each	EUR 579.6

DiaEasy? Dialyzer (800 µl) MWCO 3.5 kDa
K1018-25	Biovision	each	EUR 288

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa
K1019-10	Biovision	each	EUR 164.4

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa
K1019-25	Biovision	each	EUR 288

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa
K1020-10	Biovision	each	EUR 138

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa
K1020-100	Biovision	each	EUR 574.8

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa
K1020-25	Biovision	each	EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa
K1021-10	Biovision	each	EUR 138

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa
K1021-25	Biovision	each	EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa
K1022-10	Biovision	each	EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa
K1022-25	Biovision	each	EUR 418.8

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks
1000-10	Biovision	each	EUR 164.4

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks
1000-5	Biovision	each	EUR 124.8

DiaEasy? Dialyzer (250 µl) Floating racks
1020-10	Biovision	each	EUR 124.8

DiaEasy? Dialyzer (250 µl) Floating racks
1020-5	Biovision	each	EUR 105.6

DiaEasy? Dialyzer (3 ml) Floating racks
1016-10	Biovision	each	EUR 170.4

DiaEasy? Dialyzer (3 ml) Floating racks
1016-5	Biovision	each	EUR 130.8

DiaEasy? Dialyzer (800 µl) Floating racks
1018-10	Biovision	each	EUR 124.8

DiaEasy? Dialyzer (800 µl) Floating racks
1018-5	Biovision	each	EUR 105.6

DiaEasy? Dialyzer (250 µl) Supporting trays
1028-10	Biovision	each	EUR 124.8

DiaEasy? Dialyzer (250 µl) Supporting trays
1028-5	Biovision	each	EUR 105.6

DiaEasy? Dialyzer (3 ml) Supporting trays
1017-10	Biovision	each	EUR 157.2

DiaEasy? Dialyzer (3 ml) Supporting trays
1017-5	Biovision	each	EUR 117.6

DiaEasy? Dialyzer (800 µl) Supporting trays
1019-10	Biovision	each	EUR 124.8

DiaEasy? Dialyzer (800 µl) Supporting trays
1019-5	Biovision	each	EUR 105.6

FBS (PREMIUM)
35-015-CV	CORNING	500 mL/pk	EUR 667.2
Description: Serum; Serum

FBS Replacement
0454-50	AthenaES	50 ml	EUR 97.2

FBS Replacement
0454-500	AthenaES	500 ml	EUR 248.4

FBS (US Origin)
C0013-12	Addexbio	RT 500 mL Bottle	EUR 595

FBS Liquid Media
88-NB05	Fitzgerald	100 ml	EUR 196.8
Description: Fetal Bovine Serum (US origin)

FBS Liquid Media
MBS539303-INQUIRE	MyBiosource	INQUIRE	Ask for price

FBS, Hepatocyte Optimized
F0692-050	GenDepot	500ml	Ask for price

FBS, Melanocyte Optimized
F0695-050	GenDepot	500ml	Ask for price

Recombinant Fibrosin (FBS)
RPC473Hu01	Cloud-Clone	10ug	EUR 146

Recombinant Fibrosin (FBS)
4-RPC473Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)
RPC473Mu01	Cloud-Clone	10ug	EUR 158

Recombinant Fibrosin (FBS)
4-RPC473Mu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)
RPU51444-100ug	Biomatik Corporation	100ug	EUR 488.4

Recombinant Fibrosin (FBS)
RPU51444-1mg	Biomatik Corporation	1mg	EUR 2161.9

Recombinant Fibrosin (FBS)
RPU51444-50ug	Biomatik Corporation	50ug	EUR 391.6

Recombinant Fibrosin (FBS)
RPU51034-100ug	Biomatik Corporation	100ug	EUR 451

Recombinant Fibrosin (FBS)
RPU51034-1mg	Biomatik Corporation	1mg	EUR 1998.1

Recombinant Fibrosin (FBS)
RPU51034-50ug	Biomatik Corporation	50ug	EUR 361.9

Recombinant Fibrosin (FBS)
MBS2034181-001mg	MyBiosource	0.01mg	EUR 165

Recombinant Fibrosin (FBS)
MBS2034181-005mg	MyBiosource	0.05mg	EUR 285

Recombinant Fibrosin (FBS)
MBS2034181-01mg	MyBiosource	0.1mg	EUR 420

Recombinant Fibrosin (FBS)
MBS2034181-02mg	MyBiosource	0.2mg	EUR 510

Recombinant Fibrosin (FBS)
MBS2034181-05mg	MyBiosource	0.5mg	EUR 970

Recombinant Fibrosin (FBS)
MBS2034252-001mg	MyBiosource	0.01mg	EUR 160

Recombinant Fibrosin (FBS)
MBS2034252-005mg	MyBiosource	0.05mg	EUR 265

Recombinant Fibrosin (FBS)
MBS2034252-01mg	MyBiosource	0.1mg	EUR 390

Recombinant Fibrosin (FBS)
MBS2034252-02mg	MyBiosource	0.2mg	EUR 480

Recombinant Fibrosin (FBS)
MBS2034252-05mg	MyBiosource	0.5mg	EUR 900

FBS, Transfection Optimized
F0640-050	GenDepot	500ml	EUR 902.4

FBS, Keratinocyte Optimized
F0694-050	GenDepot	500ml	Ask for price

Refeed Medium 5% FBS
10-170100	Quidel	100 mL	Ask for price
Description: used with most cell cultures for detection of viruses other than influenza

Refeed Medium 5% FBS
10-170500	Quidel	500 mL	Ask for price
Description: used with most cell cultures for detection of viruses other than influenza

FBS - Fetal Bovine Serum
FBS001	Neuromics	500 ml	EUR 654

FBS-Fetal Bovine Serum
MBS555797-500mL	MyBiosource	500mL	EUR 615

FBS-Fetal Bovine Serum
MBS555797-5x500mL	MyBiosource	5x500mL	EUR 2615

FBS-Fetal Bovine Serum
MBS555798-500mL	MyBiosource	500mL	EUR 635

FBS-Fetal Bovine Serum
MBS555798-5x500mL	MyBiosource	5x500mL	EUR 2700

FBS Alternative (Xeno-free)
P766-50	101Bio	-	Ask for price

FBS Alternative (Xeno-free)
P766-500	101Bio	-	Ask for price

FBS (PREMIUM, HEAT INACTIVATED)
35-016-CV	CORNING	500 mL/pk	EUR 678
Description: Serum; Serum

FBS, Fibroblasts Optimized I
F0691-050	GenDepot	500ml	Ask for price

Fibrosin (FBS) Polyclonal Antibody
CAU24231-100ul	Biomatik Corporation	100ul	EUR 241.9

Fibrosin (FBS) Polyclonal Antibody
CAU24231-200ul	Biomatik Corporation	200ul	EUR 302.4

Fibrosin (FBS) Polyclonal Antibody
CAU24232-100ul	Biomatik Corporation	100ul	EUR 235.2

Fibrosin (FBS) Polyclonal Antibody
CAU24232-200ul	Biomatik Corporation	200ul	EUR 294

Fetal Bovine Serum (FBS) [500 ml]
ABP-MED-FBS0500	Allele Biotech	500ml	Ask for price

FBS Opti-Gold, US Origin
F0900-050	GenDepot	500ml	EUR 675.6

MEM Complete Medium (10%FBS)
PM150411B-125mL4	Elabscience Biotech	125 mL×4	EUR 108
Description: Complete Growth Medium

MEM Complete Medium (20%FBS)
PM150411C-125mL4	Elabscience Biotech	125 mL×4	EUR 158
Description: Complete Growth Medium

ELISA Kit for Fibrosin (FBS)
SEC473Mu	Cloud-Clone	96Т	EUR 720

MEM Complete Medium (10%FBS)
MBS2568657-4x125mL	MyBiosource	4x125mL	EUR 160

MEM Complete Medium (20%FBS)
MBS2568658-4x125mL	MyBiosource	4x125mL	EUR 195

MEMα Complete Medium (10%FBS)
PM150421B-125mL4	Elabscience Biotech	125 mL×4	EUR 108
Description: Complete Growth Medium

MEMα Complete Medium (20%FBS)
PM150421C-125mL4	Elabscience Biotech	125 mL×4	EUR 168
Description: Complete Growth Medium

IMDM Complete Medium (10%FBS)
PM150510B-125mL4	Elabscience Biotech	125 mL×4	EUR 108
Description: Complete Growth Medium

IMDM Complete Medium (20%FBS)
PM150510C-125mL4	Elabscience Biotech	125 mL×4	EUR 168
Description: Complete Growth Medium

M199 Complete Medium (10%FBS)
PM150610B-125mL4	Elabscience Biotech	125 mL×4	EUR 108
Description: Complete Growth Medium

M199 Complete Medium (20%FBS)
PM150610C-125mL4	Elabscience Biotech	125 mL×4	EUR 168
Description: Complete Growth Medium

IMDM Complete Medium (10%FBS)
MBS2568713-4x125mL	MyBiosource	4x125mL	EUR 160

IMDM Complete Medium (20%FBS)
MBS2568714-4x125mL	MyBiosource	4x125mL	EUR 200

M199 Complete Medium (10%FBS)
MBS2568720-4x125mL	MyBiosource	4x125mL	EUR 160

M199 Complete Medium (20%FBS)
MBS2568721-4x125mL	MyBiosource	4x125mL	EUR 200

Human Fibrosin(FBS)ELISA Kit
QY-E00902	Qayee Biotechnology	96T	EUR 433.2

Human Fibrosin (FBS) ELISA Kit
MBS9311876-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Fibrosin (FBS) ELISA Kit
MBS9311876-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Fibrosin (FBS) ELISA Kit
MBS9311876-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Fibrosin (FBS) ELISA Kit
MBS9311876-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

FBRS (FBS, FBS1, Probable Fibrosin-1) (AP)
MBS6417003-01mL	MyBiosource	0.1mL	EUR 950

FBRS (FBS, FBS1, Probable Fibrosin-1) (AP)
MBS6417003-5x01mL	MyBiosource	5x0.1mL	EUR 4120

FBRS (FBS, FBS1, Probable Fibrosin-1) (PE)
MBS6417013-01mL	MyBiosource	0.1mL	EUR 950

FBRS (FBS, FBS1, Probable Fibrosin-1) (PE)
MBS6417013-5x01mL	MyBiosource	5x0.1mL	EUR 4120

FBRS (FBS, FBS1, Probable Fibrosin-1) (APC)
MBS6417004-01mL	MyBiosource	0.1mL	EUR 950

FBRS (FBS, FBS1, Probable Fibrosin-1) (APC)
MBS6417004-5x01mL	MyBiosource	5x0.1mL	EUR 4120

FBRS (FBS, FBS1, Probable Fibrosin-1) (HRP)
MBS6417007-01mL	MyBiosource	0.1mL	EUR 950

FBRS (FBS, FBS1, Probable Fibrosin-1) (HRP)
MBS6417007-5x01mL	MyBiosource	5x0.1mL	EUR 4120

FBRS (FBS, FBS1, Probable Fibrosin-1) (FITC)
MBS6417006-01mL	MyBiosource	0.1mL	EUR 950