Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

Hyclone Dialyzed Fetal Bovine Serum US Origin 50 mL (SH30079.01)

HYC43 EACH
EUR 103.2

Hyclone Dialyzed Fetal Bovine Serum US Origin 100 mL (SH30079.02)

HYC45 EACH
EUR 174

Hyclone Dialyzed Fetal Bovine Serum US Origin 500 mL (SH30079.03)

HYC47 EACH
EUR 726

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBMDY30-0500 500 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered

SFBUDY30-0500 500 ml Ask for price

Hyclone Dialyzed Fetal Bovine Serum US Origin Irradiated 500 mL (SH30079.03IR)

HYC50 EACH
EUR 793.2

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 50 mL (SH30079.01HI)

HYC44 EACH
EUR 122.4

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 100 mL (SH30079.02HI)

HYC46 EACH
EUR 194.4

Hyclone Dialyzed Fetal Bovine Serum US Origin Heat Inact 500 mL (SH30079.03HI)

HYC48 EACH
EUR 771.6

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0100 100 ml Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated

SFBMDY32-0500 500 ml Ask for price

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-10 each
EUR 216

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 3.5 kDa

K1000-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa

K1001-100 each
EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 3.5 kDa

K1001-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa

K1002-100 each
EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa

K1002-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa

K1003-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 6-8 kDa

K1003-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa

K1004-100 each
EUR 1227.6

DiaEasy? Dialyzer (15 ml) MWCO 6-8 kDa

K1004-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa

K1005-100 each
EUR 1227.6

DiaEasy? Dialyzer (10 ml) MWCO 6-8 kDa

K1005-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa

K1006-100 each
EUR 1227.6

DiaEasy? Dialyzer (20 ml) MWCO 12-14 kDa

K1006-25 each
EUR 411.6

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa

K1007-10 each
EUR 216

DiaEasy? Dialyzer (15 ml) MWCO 12-14 kDa

K1007-25 each
EUR 411.6

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa

K1008-10 each
EUR 216

DiaEasy? Dialyzer (10 ml) MWCO 12-14 kDa

K1008-25 each
EUR 411.6

DiaEasy? Dialyzer (20 ml) MWCO 1 kDa

K1009-25 each
EUR 914.4

DiaEasy? Dialyzer (15 ml) MWCO 1 kDa

K1010-25 each
EUR 914.4

DiaEasy? Dialyzer (10 ml) MWCO 1 kDa

K1011-25 each
EUR 914.4

DiaEasy? Dialyzer (3 ml) MWCO 12-14 kDa

K1014-25 each
EUR 346.8

DiaEasy? Dialyzer (800 µl) MWCO 3.5 kDa

K1018-25 each
EUR 288

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-10 each
EUR 138

DiaEasy? Dialyzer (3 ml) MWCO 3.5 kDa

K1012-25 each
EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 6-8 kDa

K1013-25 each
EUR 346.8

DiaEasy? Dialyzer (3 ml) MWCO 25 kDa

K1015-25 each
EUR 588

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-10 each
EUR 301.2

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-100 each
EUR 1776

DiaEasy? Dialyzer (3 ml) MWCO 50 kDa

K1016-25 each
EUR 588

DiaEasy? Dialyzer (800 µl) MWCO 1 kDa

K1017-25 each
EUR 579.6

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa

K1019-10 each
EUR 164.4

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa

K1019-100 each
EUR 783.6

DiaEasy? Dialyzer (800 µl) MWCO 6-8 kDa

K1019-25 each
EUR 288

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-100 each
EUR 574.8

DiaEasy? Dialyzer (250 µl) MWCO 6-8 kDa

K1020-25 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa

K1021-10 each
EUR 138

DiaEasy? Dialyzer (250 µl) MWCO 12-14 kDa

K1021-25 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa

K1022-10 each
EUR 235.2

DiaEasy? Dialyzer (250 µl) MWCO 25 kDa

K1022-25 each
EUR 418.8

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks

1000-10 each
EUR 164.4

DiaEasy? Dialyzer (10, 15, 20 ml) Floating racks

1000-5 each
EUR 124.8

DiaEasy? Dialyzer (3 ml) Floating racks

1016-10 each
EUR 170.4

DiaEasy? Dialyzer (3 ml) Floating racks

1016-5 each
EUR 130.8

DiaEasy? Dialyzer (800 µl) Floating racks

1018-10 each
EUR 124.8

DiaEasy? Dialyzer (800 µl) Floating racks

1018-5 each
EUR 105.6

DiaEasy? Dialyzer (250 µl) Floating racks

1020-10 each
EUR 124.8

DiaEasy? Dialyzer (250 µl) Floating racks

1020-5 each
EUR 105.6

DiaEasy? Dialyzer (3 ml) Supporting trays

1017-10 each
EUR 157.2

DiaEasy? Dialyzer (3 ml) Supporting trays

1017-5 each
EUR 117.6

DiaEasy? Dialyzer (800 µl) Supporting trays

1019-10 each
EUR 124.8

DiaEasy? Dialyzer (800 µl) Supporting trays

1019-5 each
EUR 105.6

DiaEasy? Dialyzer (250 µl) Supporting trays

1028-10 each
EUR 124.8

DiaEasy? Dialyzer (250 µl) Supporting trays

1028-5 each
EUR 105.6

FBS (PREMIUM)

35-015-CV 500 mL/pk
EUR 667.2
Description: Serum; Serum

FBS Replacement

0454-50 50 ml
EUR 97.2

FBS Replacement

0454-500 500 ml
EUR 248.4

FBS Liquid Media

88-NB05 100 ml
EUR 196.8
Description: Fetal Bovine Serum (US origin)

FBS Liquid Media

88-NB06 500 ml
EUR 781.2
Description: FBS Liquid Media (Heat Inactivated)

FBS, Hepatocyte Optimized

F0692-050 500ml Ask for price

FBS, Melanocyte Optimized

F0695-050 500ml Ask for price

Recombinant Fibrosin (FBS)

4-RPC473Hu01
  • EUR 513.53
  • EUR 260.40
  • EUR 1595.71
  • EUR 611.90
  • EUR 1103.81
  • EUR 418.80
  • EUR 3809.28
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)

4-RPC473Mu01
  • EUR 545.78
  • EUR 268.80
  • EUR 1716.67
  • EUR 652.22
  • EUR 1184.45
  • EUR 440.40
  • EUR 4111.68
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

FBS, Transfection Optimized

F0640-050 500ml
EUR 902.4

FBS, Keratinocyte Optimized

F0694-050 500ml Ask for price

FBS - Fetal Bovine Serum

FBS001 500 ml
EUR 654

100ML FBS - Sterile - Filtered

SLS1166 100ML
EUR 91.2

FBS Alternative (Xeno-free)

P766-50 - Ask for price

FBS Alternative (Xeno-free)

P766-500 - Ask for price

FBS (PREMIUM, HEAT INACTIVATED)

35-016-CV 500 mL/pk
EUR 678
Description: Serum; Serum

FBS, Fibroblasts Optimized I

F0691-050 500ml Ask for price

Fetal Bovine Serum (FBS) [500 ml]

ABP-MED-FBS0500 500ml Ask for price

FBS Opti-Gold, US Origin

F0900-050 500ml
EUR 675.6

Human Fibrosin(FBS)ELISA Kit

QY-E00902 96T
EUR 433.2

FBS, Endothelial Cell Optimized I

F0670-050 500ml Ask for price

FBS, Endothelial Cell Optimized II

F0672-050 500ml Ask for price

FBS, Epithelical Cell Optimized I

F0680-050 500ml Ask for price

FBS, Epithelical Cell Optimized II

F0682-050 500ml Ask for price

100ML FBS - Sterile - Heat Inactivated

SLS1168 100ML
EUR 123.6

Fibrosin (FBS) Polyclonal Antibody (Mouse)

4-PAC473Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS)

Exosome-depleted FBS Media Supplement

EXO-FBS-250A-1 250 ml
EUR 837

Exosome-depleted FBS Media Supplement

EXO-FBS-50A-1 50 ml
EUR 193

Fetal Bovine Serum (FBS) [50 ml]

ABP-MED-FBS0050 50ml Ask for price

500ML FBS EU Grade Origin: Brazil

SLS1108 500ML
EUR 360

FBS - Fetal Bovine Serum USDA Origin

FBS002 500 mL
EUR 574.8

FBS Ultra Low IgG, < 5 μg/ml

F1900-050 500ml
EUR 1113.6

South American FBS Serum 500ml Bottles

35-079-CV 500ML
EUR 420

Fibrosin (FBS) Polyclonal Antibody (Mouse), PE

4-PAC473Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC

4-PAC473Mu01-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3

4-PAC473Mu01-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP

4-PAC473Mu01-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC

4-PAC473Mu01-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse)

4-PAC473Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS)

Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated

4-PAC473Mu01-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fetal Bovine Serum (FBS) proteins for ELISA

FBS15-N-1 1 ml
EUR 270

FBS-HI - Heat Inactivated Fetal Bovine Serum

FBS001-HI 500 ml
EUR 676.8

Dialysis Membrane

2392344 8unit
EUR 331.2

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE

4-PAC473Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC

4-PAC473Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3

4-PAC473Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP

4-PAC473Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC473Mu01-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC

4-PAC473Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Mini Dialysis Kit 1 kDa cutoff 250 ul

80648375 EACH
EUR 555.6

Mini Dialysis Kit 8 kDa cutoff 250 ul

80648413 EACH
EUR 555.6

Dialysis membrane, 34mm

TX0111 2m, 2m
EUR 78.79

Dialysis membrane, 44mm

TX0112 2m, 2m
EUR 82.97

Dialysis membrane, 77mm

TX0113 2m, 2m
EUR 93.41

Mini Dialysis Kit 1 kDa cutoff 2mL

80648394 EACH
EUR 555.6

Mini Dialysis Kit 8 kDa cutoff 2mL

80648432 EACH
EUR 555.6

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-1 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760-10 - Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin

P760S - Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated

4-PAC473Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG

FBS11-A 100 ul
EUR 489.6

FBS,Mouse Embryonic Stem cell and iPSC Optimized

F0650-050 500ml
EUR 902.4

FBS,Human Embryonic Stem cell and iPSC Optimized

F0660-050 500ml
EUR 902.4

Dialysis Bagholder clip Beakers

BAF182370000-6EA PK6
EUR 37.8

South American FBS Serum Heat Inactivated 500ml Bottles

35-089-CV 500ML
EUR 429.6

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7

4-PAC473Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing,15 m

LC9001-001 Roll
EUR 505.2

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m

LC9001-002 Roll
EUR 523.2

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m

LC9001-003 Roll
EUR 523.2

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m

LC9001-004 Roll
EUR 555.6

Spectra/Por ® 1 Dry Standard RC Dialysis Tubing, 30 m

LC9001-005 Roll
EUR 625.2

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing

LC9002-002 Roll
EUR 644.4

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing

LC9002-003 Roll
EUR 644.4

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing

LC9002-004 Roll
EUR 1183.2

Spectra/Por ® 2 Dry Standard RC Dialysis Tubing

LC9002-005 Roll
EUR 1183.2

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing

LC9003-001 Roll
EUR 588

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing

LC9003-002 Roll
EUR 588

Spectra/Por ® 3 Dry Standard RC Dialysis Tubing

LC9003-003 Roll
EUR 616.8

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing

LC9004-001 Roll
EUR 724.8

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing

LC9004-002 Roll
EUR 465.6

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing

LC9004-003 Roll
EUR 489.6

Spectra/Por ® 4 Dry Standard RC Dialysis Tubing

LC9004-004 Roll
EUR 547.2