Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues.

retroelements endogenous (eres) constitutes about 42% of the human genome and has been involved in common human diseases such as autoimmunity and cancer. The dominant paradigm stating that Eres is expressed in embryonic stem cells (ESCs) and germline cells but suppressed in differentiated somatic cells. Despite evidence that some eres can be expressed in RNA and protein levels in a particular context, the evaluation of their system-level expression in human tissues is lacking.Using RNA sequencing data, we analyzed the expression of ERE in 32 human tissues and cell types, including medullary thymic epithelial cells (mTECs). A tissue specificity index is calculated to identify tissue-restricted ERE family. We also analyzed the transcriptome of wild type and mTECs in autoimmune regulator (AIRE) -deficient mice.

Finally, we developed a workflow proteogenomic combining RNA sequencing and mass spectrometry (MS) to evaluate whether Eres may translate and produce MHC I-related peptide (MAP) in the B-lymphoblastoid cell lines (B-LCL) from 16 individuals. We reported that all human tissues express eres, but the extent and magnitude of the ERE expression is very heterogeneous from one network to another.

ERE expression is very high in both MHC I-tissue deficiency (ESCs and testes) and the MHC I-expressing tissue, mTECs. In the mutant mice, we reported that the extraordinary expression of Eres in mTECs is AIRE-independent. MS analysis identified 103 non-redundant MAPS ERE derived (ereMAPs) in B-LCLS. This ereMAPs privileged derived from intronic sense Eres translation. In particular, a detailed analysis of their amino acid composition revealed that the ERE derived virus MAPs.

This MAPS served homology studies show that ERE expression in somatic tissue is more pervasive and heterogeneous than anticipated. High and diversified expression of Eres in mTECs and their ability to generate MAPs indicate that Eres may play an important role in the formation of self-tolerance. Viral-like properties derived MAPS ERE showed that they were not disclosed in the mTECs be highly immunogenic.

FBS Replacement
0454-50	AthenaES	50 ml	EUR 81

FBS Replacement
0454-500	AthenaES	500 ml	EUR 207

Recombinant Fibrosin (FBS)
4-RPC473Hu01	Cloud-Clone	EUR 427.94 EUR 217.00 EUR 1329.76 EUR 509.92 EUR 919.84 EUR 349.00 EUR 3174.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Fibrosin expressed in: E.coli

Recombinant Fibrosin (FBS)
4-RPC473Mu01	Cloud-Clone	EUR 454.82 EUR 224.00 EUR 1430.56 EUR 543.52 EUR 987.04 EUR 367.00 EUR 3426.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Fibrosin expressed in: E.coli

FBS, Transfection Optimized
F0640-050	GenDepot	500ml	EUR 752

FBS, Hepatocyte Optimized
F0692-050	GenDepot	500ml	Ask for price

FBS, Keratinocyte Optimized
F0694-050	GenDepot	500ml	Ask for price

FBS, Melanocyte Optimized
F0695-050	GenDepot	500ml	Ask for price

FBS Liquid Media
88-NB05	Fitzgerald	100 ml	EUR 164
Description: Fetal Bovine Serum (US origin)

FBS Liquid Media
88-NB06	Fitzgerald	500 ml	EUR 651
Description: FBS Liquid Media (Heat Inactivated)

FBS, Fibroblasts Optimized I
F0691-050	GenDepot	500ml	Ask for price

FBS - Fetal Bovine Serum
FBS001	Neuromics	500 ml	EUR 545

FBS Alternative (Xeno-free)
P766-50	101Bio	-	Ask for price

FBS Alternative (Xeno-free)
P766-500	101Bio	-	Ask for price

FBS (PREMIUM, HEAT INACTIVATED)
35-016-CV	CORNING	500 mL/pk	EUR 565
Description: Serum; Serum

Fetal Bovine Serum, Premium, US Origin, Dialyzed
F0602-050	GenDepot	500ml	EUR 1063

500 ML FETAL BOVINE SERUM, PREMIUM (DIALYZED)
35-071-CV	CORNING	500 mL/pk	EUR 925
Description: Serum; Serum

Fibrosin (FBS) Polyclonal Antibody (Mouse)
4-PAC473Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS)

FBS, Endothelial Cell Optimized I
F0670-050	GenDepot	500ml	Ask for price

FBS, Endothelial Cell Optimized II
F0672-050	GenDepot	500ml	Ask for price

FBS, Epithelical Cell Optimized I
F0680-050	GenDepot	500ml	Ask for price

FBS, Epithelical Cell Optimized II
F0682-050	GenDepot	500ml	Ask for price

FBS Opti-Gold, US Origin
F0900-050	GenDepot	500ml	EUR 563

Human Fibrosin(FBS)ELISA Kit
QY-E00902	Qayee Biotechnology	96T	EUR 361

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse)
4-PAC473Hu01	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS)

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC
4-PAC473Mu01-APC	Cloud-Clone	EUR 351.00 EUR 3365.00 EUR 935.00 EUR 449.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Biotinylated
4-PAC473Mu01-Biotin	Cloud-Clone	EUR 316.00 EUR 2526.00 EUR 744.00 EUR 387.00 EUR 221.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Mouse), Cy3
4-PAC473Mu01-Cy3	Cloud-Clone	EUR 427.00 EUR 4445.00 EUR 1205.00 EUR 557.00 EUR 254.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Mouse), FITC
4-PAC473Mu01-FITC	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Mouse), HRP
4-PAC473Mu01-HRP	Cloud-Clone	EUR 321.00 EUR 2933.00 EUR 827.00 EUR 405.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Mouse), PE
4-PAC473Mu01-PE	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with PE.

FBS - Fetal Bovine Serum USDA Origin
FBS002	Neuromics	500 mL	EUR 479

Fetal Bovine Serum (FBS) [50 ml]
ABP-MED-FBS0050	Allele Biotech	50ml	Ask for price

Fetal Bovine Serum (FBS) [500 ml]
ABP-MED-FBS0500	Allele Biotech	500ml	Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC
4-PAC473Hu01-APC	Cloud-Clone	EUR 345.00 EUR 3275.00 EUR 912.00 EUR 440.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Biotinylated
4-PAC473Hu01-Biotin	Cloud-Clone	EUR 311.00 EUR 2460.00 EUR 727.00 EUR 381.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Biotin.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), Cy3
4-PAC473Hu01-Cy3	Cloud-Clone	EUR 419.00 EUR 4325.00 EUR 1175.00 EUR 545.00 EUR 251.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with Cy3.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), FITC
4-PAC473Hu01-FITC	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with FITC.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), HRP
4-PAC473Hu01-HRP	Cloud-Clone	EUR 316.00 EUR 2855.00 EUR 807.00 EUR 398.00 EUR 206.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with HRP.

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), PE
4-PAC473Hu01-PE	Cloud-Clone	EUR 296.00 EUR 2640.00 EUR 750.00 EUR 372.00 EUR 195.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with PE.

Fibrosin (FBS) Polyclonal Antibody (Mouse), APC-Cy7
4-PAC473Mu01-APC-Cy7	Cloud-Clone	EUR 583.00 EUR 6610.00 EUR 1750.00 EUR 778.00 EUR 324.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS Ultra Low IgG, < 5 μg/ml
F1900-050	GenDepot	500ml	EUR 928

FBS-HI - Heat Inactivated Fetal Bovine Serum
FBS001-HI	Neuromics	500 ml	EUR 564

Fetal Bovine Serum (FBS) proteins for ELISA
FBS15-N-1	Alpha Diagnostics	1 ml	EUR 225

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBMDY30-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBMDY30-0500	Equitech	500 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBUDY30-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered
SFBUDY30-0500	Equitech	500 ml	Ask for price

Fibrosin (FBS) Polyclonal Antibody (Human, Mouse), APC-Cy7
4-PAC473Hu01-APC-Cy7	Cloud-Clone	EUR 571.00 EUR 6430.00 EUR 1705.00 EUR 760.00 EUR 319.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Fibrosin (FBS). This antibody is labeled with APC-Cy7.

FBS,Mouse Embryonic Stem cell and iPSC Optimized
F0650-050	GenDepot	500ml	EUR 752

FBS,Human Embryonic Stem cell and iPSC Optimized
F0660-050	GenDepot	500ml	EUR 752

Fetal Bovine Serum (FBS), Premium, 100% US Origin
P760-1	101Bio	-	Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin
P760-10	101Bio	-	Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin
P760S	101Bio	-	Ask for price

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG
FBS11-A	Alpha Diagnostics	100 ul	EUR 408

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated
SFBMDY32-0100	Equitech	100 ml	Ask for price

Sterile filtered fetal bovine serum, dialyzed, triple 0.1 micron filtered, heat-inactivated
SFBMDY32-0500	Equitech	500 ml	Ask for price

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified
EXO-FBSHI-250A-1	SBI	250 ml	EUR 893

Exosome-depleted FBS Media Supplement Heat Inactivated - USA Certified
EXO-FBSHI-50A-1	SBI	50 ml	EUR 255

Collagenase Type I Solution 0.25% in PBS with 20% FBS
CA091-002	GenDepot	20ml	EUR 178

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested
P761-1	101Bio	-	Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested
P761-10	101Bio	-	Ask for price

Fetal Bovine Serum (FBS), Premium, 100% US Origin, ESC Tested
P761S	101Bio	-	Ask for price

Human Anti-Fetal Bovine/Calf Serum (FBS /FCS) IgG ELISA Kit, 96 tests, Quantitative
710-150-FBG	Alpha Diagnostics	1 Kit	EUR 773

Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG-Agarose affinity matrix to remove fetal bovine serum
FBS12-AS	Alpha Diagnostics	2 ml	EUR 469