Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.

Diversity-generating retroelements (DGRs) are a novel household of retroelements that generate sequence range of DNA to profit their hosts by introducing variations and accelerating the evolution of goal proteins. They exist extensively in micro organism, archaea, phage and plasmid.

However, our understanding about DGRs in pure environments was nonetheless very restricted.We developed an environment friendly computational algorithm to determine DGRs, and utilized it to characterize DGRs in additional than 80,000 sequenced bacterial genomes in addition to greater than 4,000 human metagenome datasets.

In whole, we recognized 948 non-redundant DGRs, which expanded the quantity of identified DGRs in bacterial genomes and human microbiomes by about 55%, and supplied a way more complete reference for the examine of DGRs. Phylogenetic evaluation was achieved for recognized DGRs.

Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.
Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.

The putative goal genes of DGRs have been searched, and the functions of these goal genes have been investigated with a complete alignment towards the nr database.DGR system is a robust and common mechanism to generate range. DGR evolution is carefully related to the dwelling atmosphere and their cassette buildings. Furthermore, it might influence a variety of useful processes along with receptor-binding. These outcomes considerably improved our understanding about DGRs.

Diclofenac

B3505-50 50 mg
EUR 128

Diclofenac (diethylamine)

HY-15036A 10mM/1mL
EUR 113

Diclofenac (Sodium)

HY-15037 5g
EUR 119

Diclofenac [BSA]

DAG3299 1mg
EUR 1105

Diclofenac diethylamine

20-abx185392
  • EUR 425.00
  • EUR 244.00
  • 25 g
  • 5 g

Diclofenac Sodium

B1457-10 10 mg
EUR 108
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-50 50 mg
EUR 224
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-S Evaluation Sample
EUR 81
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Diethylamine

B1928-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine

B1928-50 50 mg
EUR 128
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine

B1928-S Evaluation Sample
EUR 81
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-50 50 mg
EUR 128
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-S Evaluation Sample
EUR 81
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac sodium salt

GP9539-25G 25 g
EUR 86

Diclofenac sodium salt

GP9539-5G 5 g
EUR 54

Diclofenac potassium salt

GX9078-1G 1 g
EUR 78

Diclofenac potassium salt

GX9078-250MG 250 mg
EUR 58

Diclofenac potassium salt

GX9078-5G 5 g
EUR 150

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-100ug 100 ug
EUR 533

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-1mg 1 mg
EUR 1313

Octanoic acid (Caorylic acid)

O5678 250ml
EUR 67.4

Okadaic acid, free acid

OL1198 50ug
EUR 192.68

Fumalic acid(Ferulic acid)

E1KS2300 50mg
EUR 325

DL-Maleic acid (Toxilic acid)

MA0333 250g
EUR 64.5

D-Glucuronic acid, free acid

GB0482 5g
EUR 155.16

ICG acid

189 5 mg
EUR 219

Salicylic acid

SB0817 250g
EUR 102.2

Sorbic acid

SB0899 500g
EUR 71.75

Succinic acid

SD0496 500g
EUR 70.01

Anacardic Acid

M37000 5 mg
EUR 183.4
Description: kits suitable for this type of research

Valproic Acid

M41002 500 mg
EUR 128.3
Description: The best epigenetics products

Ginkgolic acid

M75004 5 mg
EUR 701.05
Description: kits suitable for this type of research

Mucic acid

MD1225 50g
EUR 69.14

Nalidixic Acid

N011-100G 100 g
EUR 172

Nalidixic Acid

N011-25G 25 g
EUR 77

Neochlorogenic acid

N050-10MG 10 mg
EUR 172

Neochlorogenic acid

N050-50MG 50 mg
EUR 617

Oxolinic acid

O002-25G 25 g
EUR 335

Oxolinic acid

O002-5G 5 g
EUR 120

Lactobionic acid

L017-25G 25 g
EUR 99

Mycophenolic Acid

M012-250MG 250 mg
EUR 212

Mycophenolic Acid

M012-50MG 50 mg
EUR 73

Pipemidic acid

P009-100G 100 g
EUR 411

Pipemidic acid

P009-10G 10 g
EUR 91

Pseudomonic acid

P095-100MG 100 mg
EUR 708

Pseudomonic acid

P095-25MG 25 mg
EUR 224

Zoledronic Acid

HY-13777 100mg
EUR 229

Retinoic acid

HY-14649 10mM/1mL
EUR 126

Levomefolic acid

HY-14781 10mM/1mL
EUR 231

Minodronic acid

HY-16322 10mg
EUR 108

Folic acid

HY-16637 500mg
EUR 108

Pirinixic acid

HY-16995 250mg
EUR 354

Folinic acid

HY-17556 100mg
EUR 667

Lipoic acid

HY-18733 500mg
EUR 133

Ethylmalonic acid

HY-34740 500mg
EUR 108

Octanoic acid

HY-41417 5g
EUR 119

(-)-Aspartic acid

HY-42068 5g
EUR 119

Asparagusic acid

HY-50730 100mg
EUR 609

Chenodeoxycholic Acid

HY-76847 10mM/1mL
EUR 126

Glyoxalic acid

HY-79494 500mg
EUR 108

Benzenebutyric acid

HY-A0281 500mg
EUR 108

Pamidronic acid

HY-B0012 10mM/1mL
EUR 172

Risedronic acid

HY-B0148 500mg
EUR 402

Tranexamic acid

HY-B0149 10mM/1mL
EUR 113

Salicylic acid

HY-B0167 50g
EUR 160

Lithocholic acid

HY-B0172 500mg
EUR 108

Ellagic acid

HY-B0183 500mg
EUR 108

Etidronic acid

HY-B0302 1g
EUR 142

Tolfenamic Acid

HY-B0335 500mg
EUR 108

Nalidixic acid

HY-B0398 500mg
EUR 108

Mycophenolic acid

HY-B0421 1g
EUR 185

Niflumic acid

HY-B0493 10mM/1mL
EUR 141

Ibandronic acid

HY-B0515A 100mg
EUR 215

Cyclamic acid

HY-B0541 5g
EUR 533

Mefenamic acid

HY-B0574 500mg
EUR 113

Hyaluronic acid

HY-B0633A 50mg
EUR 119

Eicosapentaenoic Acid

HY-B0660 10mM/1mL
EUR 134

Azelaic acid

HY-B0704 10mM/1mL
EUR 113

Carglumic Acid

HY-B0711 200mg
EUR 119

Fenofibric acid

HY-B0760 500mg
EUR 108

Betulinic acid

HY-10529 10mM/1mL
EUR 131

Valproic acid

HY-10585 10mM/1mL
EUR 113

Gadopentetic acid

HY-107353 100mg
EUR 108

Arundic Acid

HY-107661 5mg
EUR 337

Medronic acid

HY-108309 10mM/1mL
EUR 113

Arachidonic acid

HY-109590 10mg
EUR 131

Aminomalonic acid

HY-112052 100mg
EUR 223

Urocanic acid

HY-113008 500mg
EUR 108

Hydroxypyruvic acid

HY-113013 5mg
EUR 371

Elaidic acid

HY-113016 100mg
EUR 108

Mevalonic acid

HY-113071 5mg
EUR 268

Argininic acid

HY-113079 5mg
EUR 223

Paullinic acid

HY-113094 10mg
EUR 302

Indolelactic acid

HY-113099 10mg
EUR 131

Eicosadienoic acid

HY-113130 25mg
EUR 119

Bovinic acid

HY-113162 10mg
EUR 153

Ursocholic acid

HY-113212 10mg
EUR 452

Hydroxyphenyllactic acid

HY-113219 50mg
EUR 176

Oxoadipic acid

HY-113227 10mg
EUR 268

Dihydrofolic acid

HY-113267 5mg
EUR 337

Homogentisic acid

HY-113283 10mg
EUR 142

Ureidopropionic acid

HY-113285 100mg
EUR 153

Citraconic acid

HY-113298 5g
EUR 119

Hexacosanoic acid

HY-113301 10mg
EUR 119

Aminoadipic acid

HY-113328 1g
EUR 153

Nicotinuric acid

HY-113353 10mM/1mL
EUR 126

Petroselinic acid

HY-113362 10mM/1mL
EUR 113

Guanidinosuccinic acid

HY-113373 100mg
EUR 257

Imidazoleacetic acid

HY-113413 50mg
EUR 223

Obeticholic acid

HY-12222 100mg
EUR 383

Bempedoic acid

HY-12357 100mg
EUR 567

Eicosatetraynoic acid

HY-124108 1mg
EUR 160

Pentacosanoic acid

HY-124422 50mg
EUR 108

Glycodeoxycholic Acid

HY-125731 50mg
EUR 211

Phosphonoacetic acid

HY-128744 100mg
EUR 108

Oseltamivir (acid)

HY-13318 10mM/1mL
EUR 148

Fusidic acid

F019-100MG 100 mg
EUR 84

Fusidic acid

F019-1G 1 g
EUR 291

Hydrochloric acid

HC6025 2.5L
EUR 97.85

Benzophenonetetracarboxylic acid

HY-100511 100mg
EUR 257

Benzenepentacarboxylic Acid

HY-100512 500mg
EUR 160

Kynurenic acid

HY-100806 10mM/1mL
EUR 113

Quinolinic acid

HY-100807 1g
EUR 119

Spaglumic Acid

HY-100921 50mg
EUR 187

Docosatrienoic Acid

HY-101408 10mg
EUR 173

Vanilpyruvic acid

HY-101416 10mg
EUR 147

Bucloxic acid

HY-101581 20mg
EUR 1703

Methylmalonic acid

HY-103395 500mg
EUR 108

Fuchsin acid

FB0469 100g
EUR 98.72

Gallic acid

GB0476 250g
EUR 71.75

Chlorogenic acid

HY-N0055 10mM/1mL
EUR 126

Ferulic acid

HY-N0060 500mg
EUR 165

Ginkgolic Acid

HY-N0077 10mg
EUR 402

Gambogic Acid

HY-N0087 5mg
EUR 133

Shikimic acid

HY-N0130 100mg
EUR 119

Ursolic acid

HY-N0140 10mM/1mL
EUR 156

Oleanolic Acid

HY-N0156 500mg
EUR 278

Orotic acid

HY-N0157 10mM/1mL
EUR 126

Hyodeoxycholic acid

HY-N0169 100mg
EUR 119

Caffeic acid

HY-N0172 5g
EUR 147

Glycyrrhizic acid

HY-N0184 100mg
EUR 147

Asiatic acid

HY-N0194 100mg
EUR 337

Nordihydroguaiaretic acid

HY-N0198 100mg
EUR 119

Benzoic acid

HY-N0216 100mg
EUR 108

Echinocystic acid

HY-N0271 10mM/1mL
EUR 172

Corosolic acid

HY-N0280 10mg
EUR 250

Protocatechuic acid

HY-N0294 1g
EUR 133

Caftaric acid

HY-N0321 10mM/1mL
EUR 414

Cholic acid

HY-N0324 10mM/1mL
EUR 126

Syringic acid

HY-N0339 100mg
EUR 108

Pachymic acid

HY-N0371 50mg
EUR 1262

Homovanillic acid

HY-N0384 100mg
EUR 119

Succinic acid

HY-N0420 10mM/1mL
EUR 151

Cichoric Acid

HY-N0457 10mg
EUR 133

Roburic acid

HY-N0481 1mg
EUR 113

Gallic acid

HY-N0523 500mg
EUR 147

Rosmarinic acid

HY-N0529 100mg
EUR 173

Deoxycholic acid

HY-N0593 10mM/1mL
EUR 126

Deacetylasperulosidic Acid

HY-N0594 10mg
EUR 436

Cinnamic acid

HY-N0610A 10mM/1mL
EUR 113

Maslinic acid

HY-N0629 25mg
EUR 436

Carnosic acid

HY-N0644 50mg
EUR 223

(+)-Usnic acid

HY-N0656A 100mg
EUR 108

Vanillic acid

HY-N0708 10mM/1mL
EUR 113

Neochlorogenic acid

HY-N0722 10mg
EUR 326

Linoleic acid

HY-N0729 10mM/1mL
EUR 113

Isoferulic acid

HY-N0761 10mM/1mL
EUR 113

Cryptochlorogenic acid

HY-N0787 10mM/1mL
EUR 126

Phytic acid

HY-N0814 250mg
EUR 108

Lithospermic acid

HY-N0823 5mg
EUR 142

Palmitic acid

HY-N0830 10mM/1mL
EUR 113

Quillaic acid

HY-N0839 5mg
EUR 533

Glycocholic acid

HY-N1423 10mM/1mL
EUR 113

Glycoursodeoxycholic acid

HY-N1424 10mg
EUR 119

Citric acid

HY-N1428 100mg
EUR 108

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