Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.
Diversity-generating retroelements (DGRs) are a novel household of retroelements that generate sequence range of DNA to profit their hosts by introducing variations and accelerating the evolution of goal proteins. They exist extensively in micro organism, archaea, phage and plasmid.
However, our understanding about DGRs in pure environments was nonetheless very restricted.We developed an environment friendly computational algorithm to determine DGRs, and utilized it to characterize DGRs in additional than 80,000 sequenced bacterial genomes in addition to greater than 4,000 human metagenome datasets.
In whole, we recognized 948 non-redundant DGRs, which expanded the quantity of identified DGRs in bacterial genomes and human microbiomes by about 55%, and supplied a way more complete reference for the examine of DGRs. Phylogenetic evaluation was achieved for recognized DGRs.
The putative goal genes of DGRs have been searched, and the functions of these goal genes have been investigated with a complete alignment towards the nr database.DGR system is a robust and common mechanism to generate range. DGR evolution is carefully related to the dwelling atmosphere and their cassette buildings. Furthermore, it might influence a variety of useful processes along with receptor-binding. These outcomes considerably improved our understanding about DGRs.
Diclofenac |
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| B3505-50 | ApexBio | 50 mg | EUR 128 |
Diclofenac (diethylamine) |
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| HY-15036A | MedChemExpress | 10mM/1mL | EUR 113 |
Diclofenac (Sodium) |
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| HY-15037 | MedChemExpress | 5g | EUR 119 |
Diclofenac [BSA] |
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| DAG3299 | Creative Diagnostics | 1mg | EUR 1105 |
Diclofenac diethylamine |
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| 20-abx185392 | Abbexa |
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Diclofenac Sodium |
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| B1457-10 | ApexBio | 10 mg | EUR 108 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-50 | ApexBio | 50 mg | EUR 224 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Diethylamine |
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| B1928-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Diethylamine |
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| B1928-50 | ApexBio | 50 mg | EUR 128 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Diethylamine |
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| B1928-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Potassium |
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| B1929-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Potassium |
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| B1929-50 | ApexBio | 50 mg | EUR 128 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Potassium |
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| B1929-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac sodium salt |
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| GP9539-25G | Glentham Life Sciences | 25 g | EUR 86 |
Diclofenac sodium salt |
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| GP9539-5G | Glentham Life Sciences | 5 g | EUR 54 |
Diclofenac potassium salt |
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| GX9078-1G | Glentham Life Sciences | 1 g | EUR 78 |
Diclofenac potassium salt |
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| GX9078-250MG | Glentham Life Sciences | 250 mg | EUR 58 |
Diclofenac potassium salt |
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| GX9078-5G | Glentham Life Sciences | 5 g | EUR 150 |
Mouse Anti-Diclofenac monoclonal antibody, clone DC |
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| CABT-L4252-100ug | Creative Diagnostics | 100 ug | EUR 533 |
Mouse Anti-Diclofenac monoclonal antibody, clone DC |
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| CABT-L4252-1mg | Creative Diagnostics | 1 mg | EUR 1313 |
Octanoic acid (Caorylic acid) |
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| O5678 | Bio Basic | 250ml | EUR 67.4 |
Okadaic acid, free acid |
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| OL1198 | Bio Basic | 50ug | EUR 192.68 |
Fumalic acid(Ferulic acid) |
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| E1KS2300 | EnoGene | 50mg | EUR 325 |
DL-Maleic acid (Toxilic acid) |
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| MA0333 | Bio Basic | 250g | EUR 64.5 |
D-Glucuronic acid, free acid |
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| GB0482 | Bio Basic | 5g | EUR 155.16 |
ICG acid |
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| 189 | AAT Bioquest | 5 mg | EUR 219 |
Salicylic acid |
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| SB0817 | Bio Basic | 250g | EUR 102.2 |
Sorbic acid |
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| SB0899 | Bio Basic | 500g | EUR 71.75 |
Succinic acid |
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| SD0496 | Bio Basic | 500g | EUR 70.01 |
Anacardic Acid |
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| M37000 | EpiGentek | 5 mg | EUR 183.4 |
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Description: kits suitable for this type of research |
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Valproic Acid |
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| M41002 | EpiGentek | 500 mg | EUR 128.3 |
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Description: The best epigenetics products |
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Ginkgolic acid |
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| M75004 | EpiGentek | 5 mg | EUR 701.05 |
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Description: kits suitable for this type of research |
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Mucic acid |
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| MD1225 | Bio Basic | 50g | EUR 69.14 |
Nalidixic Acid |
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| N011-100G | TOKU-E | 100 g | EUR 172 |
Nalidixic Acid |
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| N011-25G | TOKU-E | 25 g | EUR 77 |
Neochlorogenic acid |
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| N050-10MG | TOKU-E | 10 mg | EUR 172 |
Neochlorogenic acid |
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| N050-50MG | TOKU-E | 50 mg | EUR 617 |
Oxolinic acid |
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| O002-25G | TOKU-E | 25 g | EUR 335 |
Oxolinic acid |
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| O002-5G | TOKU-E | 5 g | EUR 120 |
Lactobionic acid |
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| L017-25G | TOKU-E | 25 g | EUR 99 |
Mycophenolic Acid |
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| M012-250MG | TOKU-E | 250 mg | EUR 212 |
Mycophenolic Acid |
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| M012-50MG | TOKU-E | 50 mg | EUR 73 |
Pipemidic acid |
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| P009-100G | TOKU-E | 100 g | EUR 411 |
Pipemidic acid |
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| P009-10G | TOKU-E | 10 g | EUR 91 |
Pseudomonic acid |
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| P095-100MG | TOKU-E | 100 mg | EUR 708 |
Pseudomonic acid |
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| P095-25MG | TOKU-E | 25 mg | EUR 224 |
Zoledronic Acid |
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| HY-13777 | MedChemExpress | 100mg | EUR 229 |
Retinoic acid |
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| HY-14649 | MedChemExpress | 10mM/1mL | EUR 126 |
Levomefolic acid |
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| HY-14781 | MedChemExpress | 10mM/1mL | EUR 231 |
Minodronic acid |
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| HY-16322 | MedChemExpress | 10mg | EUR 108 |
Folic acid |
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| HY-16637 | MedChemExpress | 500mg | EUR 108 |
Pirinixic acid |
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| HY-16995 | MedChemExpress | 250mg | EUR 354 |
Folinic acid |
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| HY-17556 | MedChemExpress | 100mg | EUR 667 |
Lipoic acid |
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| HY-18733 | MedChemExpress | 500mg | EUR 133 |
Ethylmalonic acid |
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| HY-34740 | MedChemExpress | 500mg | EUR 108 |
Octanoic acid |
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| HY-41417 | MedChemExpress | 5g | EUR 119 |
(-)-Aspartic acid |
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| HY-42068 | MedChemExpress | 5g | EUR 119 |
Asparagusic acid |
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| HY-50730 | MedChemExpress | 100mg | EUR 609 |
Chenodeoxycholic Acid |
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| HY-76847 | MedChemExpress | 10mM/1mL | EUR 126 |
Glyoxalic acid |
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| HY-79494 | MedChemExpress | 500mg | EUR 108 |
Benzenebutyric acid |
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| HY-A0281 | MedChemExpress | 500mg | EUR 108 |
Pamidronic acid |
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| HY-B0012 | MedChemExpress | 10mM/1mL | EUR 172 |
Risedronic acid |
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| HY-B0148 | MedChemExpress | 500mg | EUR 402 |
Tranexamic acid |
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| HY-B0149 | MedChemExpress | 10mM/1mL | EUR 113 |
Salicylic acid |
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| HY-B0167 | MedChemExpress | 50g | EUR 160 |
Lithocholic acid |
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| HY-B0172 | MedChemExpress | 500mg | EUR 108 |
Ellagic acid |
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| HY-B0183 | MedChemExpress | 500mg | EUR 108 |
Etidronic acid |
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| HY-B0302 | MedChemExpress | 1g | EUR 142 |
Tolfenamic Acid |
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| HY-B0335 | MedChemExpress | 500mg | EUR 108 |
Nalidixic acid |
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| HY-B0398 | MedChemExpress | 500mg | EUR 108 |
Mycophenolic acid |
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| HY-B0421 | MedChemExpress | 1g | EUR 185 |
Niflumic acid |
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| HY-B0493 | MedChemExpress | 10mM/1mL | EUR 141 |
Ibandronic acid |
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| HY-B0515A | MedChemExpress | 100mg | EUR 215 |
Cyclamic acid |
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| HY-B0541 | MedChemExpress | 5g | EUR 533 |
Mefenamic acid |
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| HY-B0574 | MedChemExpress | 500mg | EUR 113 |
Hyaluronic acid |
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| HY-B0633A | MedChemExpress | 50mg | EUR 119 |
Eicosapentaenoic Acid |
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| HY-B0660 | MedChemExpress | 10mM/1mL | EUR 134 |
Azelaic acid |
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| HY-B0704 | MedChemExpress | 10mM/1mL | EUR 113 |
Carglumic Acid |
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| HY-B0711 | MedChemExpress | 200mg | EUR 119 |
Fenofibric acid |
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| HY-B0760 | MedChemExpress | 500mg | EUR 108 |
Betulinic acid |
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| HY-10529 | MedChemExpress | 10mM/1mL | EUR 131 |
Valproic acid |
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| HY-10585 | MedChemExpress | 10mM/1mL | EUR 113 |
Gadopentetic acid |
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| HY-107353 | MedChemExpress | 100mg | EUR 108 |
Arundic Acid |
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| HY-107661 | MedChemExpress | 5mg | EUR 337 |
Medronic acid |
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| HY-108309 | MedChemExpress | 10mM/1mL | EUR 113 |
Arachidonic acid |
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| HY-109590 | MedChemExpress | 10mg | EUR 131 |
Aminomalonic acid |
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| HY-112052 | MedChemExpress | 100mg | EUR 223 |
Urocanic acid |
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| HY-113008 | MedChemExpress | 500mg | EUR 108 |
Hydroxypyruvic acid |
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| HY-113013 | MedChemExpress | 5mg | EUR 371 |
Elaidic acid |
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| HY-113016 | MedChemExpress | 100mg | EUR 108 |
Mevalonic acid |
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| HY-113071 | MedChemExpress | 5mg | EUR 268 |
Argininic acid |
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| HY-113079 | MedChemExpress | 5mg | EUR 223 |
Paullinic acid |
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| HY-113094 | MedChemExpress | 10mg | EUR 302 |
Indolelactic acid |
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| HY-113099 | MedChemExpress | 10mg | EUR 131 |
Eicosadienoic acid |
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| HY-113130 | MedChemExpress | 25mg | EUR 119 |
Bovinic acid |
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| HY-113162 | MedChemExpress | 10mg | EUR 153 |
Ursocholic acid |
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| HY-113212 | MedChemExpress | 10mg | EUR 452 |
Hydroxyphenyllactic acid |
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| HY-113219 | MedChemExpress | 50mg | EUR 176 |
Oxoadipic acid |
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| HY-113227 | MedChemExpress | 10mg | EUR 268 |
Dihydrofolic acid |
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| HY-113267 | MedChemExpress | 5mg | EUR 337 |
Homogentisic acid |
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| HY-113283 | MedChemExpress | 10mg | EUR 142 |
Ureidopropionic acid |
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| HY-113285 | MedChemExpress | 100mg | EUR 153 |
Citraconic acid |
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| HY-113298 | MedChemExpress | 5g | EUR 119 |
Hexacosanoic acid |
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| HY-113301 | MedChemExpress | 10mg | EUR 119 |
Aminoadipic acid |
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| HY-113328 | MedChemExpress | 1g | EUR 153 |
Nicotinuric acid |
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| HY-113353 | MedChemExpress | 10mM/1mL | EUR 126 |
Petroselinic acid |
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| HY-113362 | MedChemExpress | 10mM/1mL | EUR 113 |
Guanidinosuccinic acid |
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| HY-113373 | MedChemExpress | 100mg | EUR 257 |
Imidazoleacetic acid |
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| HY-113413 | MedChemExpress | 50mg | EUR 223 |
Obeticholic acid |
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| HY-12222 | MedChemExpress | 100mg | EUR 383 |
Bempedoic acid |
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| HY-12357 | MedChemExpress | 100mg | EUR 567 |
Eicosatetraynoic acid |
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| HY-124108 | MedChemExpress | 1mg | EUR 160 |
Pentacosanoic acid |
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| HY-124422 | MedChemExpress | 50mg | EUR 108 |
Glycodeoxycholic Acid |
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| HY-125731 | MedChemExpress | 50mg | EUR 211 |
Phosphonoacetic acid |
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| HY-128744 | MedChemExpress | 100mg | EUR 108 |
Oseltamivir (acid) |
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| HY-13318 | MedChemExpress | 10mM/1mL | EUR 148 |
Fusidic acid |
|||
| F019-100MG | TOKU-E | 100 mg | EUR 84 |
Fusidic acid |
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| F019-1G | TOKU-E | 1 g | EUR 291 |
Hydrochloric acid |
|||
| HC6025 | Bio Basic | 2.5L | EUR 97.85 |
Benzophenonetetracarboxylic acid |
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| HY-100511 | MedChemExpress | 100mg | EUR 257 |
Benzenepentacarboxylic Acid |
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| HY-100512 | MedChemExpress | 500mg | EUR 160 |
Kynurenic acid |
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| HY-100806 | MedChemExpress | 10mM/1mL | EUR 113 |
Quinolinic acid |
|||
| HY-100807 | MedChemExpress | 1g | EUR 119 |
Spaglumic Acid |
|||
| HY-100921 | MedChemExpress | 50mg | EUR 187 |
Docosatrienoic Acid |
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| HY-101408 | MedChemExpress | 10mg | EUR 173 |
Vanilpyruvic acid |
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| HY-101416 | MedChemExpress | 10mg | EUR 147 |
Bucloxic acid |
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| HY-101581 | MedChemExpress | 20mg | EUR 1703 |
Methylmalonic acid |
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| HY-103395 | MedChemExpress | 500mg | EUR 108 |
Fuchsin acid |
|||
| FB0469 | Bio Basic | 100g | EUR 98.72 |
Gallic acid |
|||
| GB0476 | Bio Basic | 250g | EUR 71.75 |
Chlorogenic acid |
|||
| HY-N0055 | MedChemExpress | 10mM/1mL | EUR 126 |
Ferulic acid |
|||
| HY-N0060 | MedChemExpress | 500mg | EUR 165 |
Ginkgolic Acid |
|||
| HY-N0077 | MedChemExpress | 10mg | EUR 402 |
Gambogic Acid |
|||
| HY-N0087 | MedChemExpress | 5mg | EUR 133 |
Shikimic acid |
|||
| HY-N0130 | MedChemExpress | 100mg | EUR 119 |
Ursolic acid |
|||
| HY-N0140 | MedChemExpress | 10mM/1mL | EUR 156 |
Oleanolic Acid |
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| HY-N0156 | MedChemExpress | 500mg | EUR 278 |
Orotic acid |
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| HY-N0157 | MedChemExpress | 10mM/1mL | EUR 126 |
Hyodeoxycholic acid |
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| HY-N0169 | MedChemExpress | 100mg | EUR 119 |
Caffeic acid |
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| HY-N0172 | MedChemExpress | 5g | EUR 147 |
Glycyrrhizic acid |
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| HY-N0184 | MedChemExpress | 100mg | EUR 147 |
Asiatic acid |
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| HY-N0194 | MedChemExpress | 100mg | EUR 337 |
Nordihydroguaiaretic acid |
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| HY-N0198 | MedChemExpress | 100mg | EUR 119 |
Benzoic acid |
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| HY-N0216 | MedChemExpress | 100mg | EUR 108 |
Echinocystic acid |
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| HY-N0271 | MedChemExpress | 10mM/1mL | EUR 172 |
Corosolic acid |
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| HY-N0280 | MedChemExpress | 10mg | EUR 250 |
Protocatechuic acid |
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| HY-N0294 | MedChemExpress | 1g | EUR 133 |
Caftaric acid |
|||
| HY-N0321 | MedChemExpress | 10mM/1mL | EUR 414 |
Cholic acid |
|||
| HY-N0324 | MedChemExpress | 10mM/1mL | EUR 126 |
Syringic acid |
|||
| HY-N0339 | MedChemExpress | 100mg | EUR 108 |
Pachymic acid |
|||
| HY-N0371 | MedChemExpress | 50mg | EUR 1262 |
Homovanillic acid |
|||
| HY-N0384 | MedChemExpress | 100mg | EUR 119 |
Succinic acid |
|||
| HY-N0420 | MedChemExpress | 10mM/1mL | EUR 151 |
Cichoric Acid |
|||
| HY-N0457 | MedChemExpress | 10mg | EUR 133 |
Roburic acid |
|||
| HY-N0481 | MedChemExpress | 1mg | EUR 113 |
Gallic acid |
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| HY-N0523 | MedChemExpress | 500mg | EUR 147 |
Rosmarinic acid |
|||
| HY-N0529 | MedChemExpress | 100mg | EUR 173 |
Deoxycholic acid |
|||
| HY-N0593 | MedChemExpress | 10mM/1mL | EUR 126 |
Deacetylasperulosidic Acid |
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| HY-N0594 | MedChemExpress | 10mg | EUR 436 |
Cinnamic acid |
|||
| HY-N0610A | MedChemExpress | 10mM/1mL | EUR 113 |
Maslinic acid |
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| HY-N0629 | MedChemExpress | 25mg | EUR 436 |
Carnosic acid |
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| HY-N0644 | MedChemExpress | 50mg | EUR 223 |
(+)-Usnic acid |
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| HY-N0656A | MedChemExpress | 100mg | EUR 108 |
Vanillic acid |
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| HY-N0708 | MedChemExpress | 10mM/1mL | EUR 113 |
Neochlorogenic acid |
|||
| HY-N0722 | MedChemExpress | 10mg | EUR 326 |
Linoleic acid |
|||
| HY-N0729 | MedChemExpress | 10mM/1mL | EUR 113 |
Isoferulic acid |
|||
| HY-N0761 | MedChemExpress | 10mM/1mL | EUR 113 |
Cryptochlorogenic acid |
|||
| HY-N0787 | MedChemExpress | 10mM/1mL | EUR 126 |
Phytic acid |
|||
| HY-N0814 | MedChemExpress | 250mg | EUR 108 |
Lithospermic acid |
|||
| HY-N0823 | MedChemExpress | 5mg | EUR 142 |
Palmitic acid |
|||
| HY-N0830 | MedChemExpress | 10mM/1mL | EUR 113 |
Quillaic acid |
|||
| HY-N0839 | MedChemExpress | 5mg | EUR 533 |
Glycocholic acid |
|||
| HY-N1423 | MedChemExpress | 10mM/1mL | EUR 113 |
Glycoursodeoxycholic acid |
|||
| HY-N1424 | MedChemExpress | 10mg | EUR 119 |
Citric acid |
|||
| HY-N1428 | MedChemExpress | 100mg | EUR 108 |