Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.

Diversity-generating retroelements (DGRs) are a novel household of retroelements that generate sequence range of DNA to profit their hosts by introducing variations and accelerating the evolution of goal proteins. They exist extensively in micro organism, archaea, phage and plasmid.

However, our understanding about DGRs in pure environments was nonetheless very restricted.We developed an environment friendly computational algorithm to determine DGRs, and utilized it to characterize DGRs in additional than 80,000 sequenced bacterial genomes in addition to greater than 4,000 human metagenome datasets.

In whole, we recognized 948 non-redundant DGRs, which expanded the quantity of identified DGRs in bacterial genomes and human microbiomes by about 55%, and supplied a way more complete reference for the examine of DGRs. Phylogenetic evaluation was achieved for recognized DGRs.

Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.
Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.

The putative goal genes of DGRs have been searched, and the functions of these goal genes have been investigated with a complete alignment towards the nr database.DGR system is a robust and common mechanism to generate range. DGR evolution is carefully related to the dwelling atmosphere and their cassette buildings. Furthermore, it might influence a variety of useful processes along with receptor-binding. These outcomes considerably improved our understanding about DGRs.

Diclofenac

B3505-50 50 mg
EUR 128

Diclofenac diethylamine

20-abx185392
  • EUR 425.00
  • EUR 244.00
  • 25 g
  • 5 g

Diclofenac (diethylamine)

HY-15036A 10mM/1mL
EUR 113

Diclofenac (Sodium)

HY-15037 5g
EUR 119

Diclofenac [BSA]

DAG3299 1mg
EUR 1105

Diclofenac Sodium

B1457-10 10 mg
EUR 108
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-50 50 mg
EUR 224
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Sodium

B1457-S Evaluation Sample
EUR 81
Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam

Diclofenac Diethylamine

B1928-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine

B1928-50 50 mg
EUR 128
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine

B1928-S Evaluation Sample
EUR 81
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-50 50 mg
EUR 128
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium

B1929-S Evaluation Sample
EUR 81
Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac sodium salt

GP9539-25G 25 g
EUR 86

Diclofenac sodium salt

GP9539-5G 5 g
EUR 54

Diclofenac potassium salt

GX9078-1G 1 g
EUR 78

Diclofenac potassium salt

GX9078-250MG 250 mg
EUR 58

Diclofenac potassium salt

GX9078-5G 5 g
EUR 150

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-100ug 100 ug
EUR 533

Mouse Anti-Diclofenac monoclonal antibody, clone DC

CABT-L4252-1mg 1 mg
EUR 1313

Octanoic acid (Caorylic acid)

O5678 250ml
EUR 67.4

Okadaic acid, free acid

OL1198 50ug
EUR 192.68

Fumalic acid(Ferulic acid)

E1KS2300 50mg
EUR 325

DL-Maleic acid (Toxilic acid)

MA0333 250g
EUR 64.5

D-Glucuronic acid, free acid

GB0482 5g
EUR 155.16

?-Glycyrrhetinic acid

9586-1G
EUR 120

Carnosic acid

TB0003 3X20mg
EUR 252

Rosmarinic acid

TB0004 4X20mg
EUR 268

Acetylursolic acid

TB00045 5mg
EUR 739

Benzoic acid

TB00049 8XX50mg
EUR 274

Cichoric Acid

TB0008-0020 20mg
EUR 249

Polygalic acid

TB0011-0100 20mg
EUR 228

Dihydroguaiaretic acid

TB00124 5mg
EUR 697

Polygalacic acid

TB0013 20mg
EUR 262

Chlorogenic acid

TB0022 8XX20mg
EUR 274

Neochlorogenic acid

TB0023 20mg
EUR 203

Cryptochlorogenic acid

TB0024 20mg
EUR 228

Eichlerianic acid

TB00334 5mg
EUR 847

Isocupressic acid

TB00361 5mg
EUR 847

Glycyrrhizic acid

TB0037 4X20mg
EUR 251

Glycyrrhetinic acid

TB0038 10X20mg
EUR 274

Fumaric acid

TB00430 10X100mg
EUR 274

Fumalic acid

TB0050 10X20mg
EUR 274

Euscaphic acid

TB00512 20mg
EUR 612

Acetylisocupressic acid

TB00580 5mg
EUR 911

Esculentic acid

TB00598 5mg
EUR 847

Hardwickiic acid

TB00631 5mg
EUR 847

Decanedioic acid

TB00658 4X100mg
EUR 268

Ceanothic acid

TB00872 5mg
EUR 867

Quinovic acid

TB00888 5mg
EUR 867

Cinnamic Acid

TB0095-1000 10X100mg
EUR 274

Lipoic acid

TB0098 10X20mg
EUR 274

Alphitolic acid

TB01052 5mg
EUR 867

Gallic acid

TB0110 10X50mg
EUR 274

Shikimic acid

TB0112 10X20mg
EUR 274

Confluentic acid

TB01196 unit Ask for price

Arjunolic acid

TB01216 5mg
EUR 739

Communic acid

TB01436 5mg
EUR 867

Phytic acid

TB0169 8XX20mg
EUR 274

Cholic acid

TB0171 10X20mg
EUR 274

Hyodeoxycholic acid

TB0172 10X20mg
EUR 274

Deoxycholic acid

TB0173 10X20mg
EUR 274

Moronic acid

TB01734 5mg
EUR 847

Usinic Acid

TB0177-0500 4X25mg
EUR 268

Caffeic Acid

TB0212-0500 10X20mg
EUR 274

Rehmannic acid

TB02271 5mg
EUR 738

Grandiflorenic acid

TB02318 5mg
EUR 738

Oleanolic acid

TB0237-1000 10X20mg
EUR 274

Kaurenoic acid

TB02424 20mg
EUR 249

Isopimaric acid

TB02501 5mg
EUR 763

Hydrocinnamic acid

TB02940 unit Ask for price

Asiatic acid

TB0298-0200 4X20mg
EUR 268

Palmitic acid

TB0314-0020 6X20mg
EUR 257

Loganic acid

TB0330-0020 3X20mg
EUR 291

Betulinic Acid

TB0348-0020 8XX20mg
EUR 274

Corosolic Acid

TB0356-0020 20mg
EUR 228

Geniposidic Acid

TB0376-1000 5X20mg
EUR 274

Roburic Acid

TB0383-0020 20mg
EUR 249

Homovanillic acid

TB0459 4X20mg
EUR 268

Lithospermic Acid

TB0459-0020 25mg
EUR 271

Isoferulic acid

TB0485-0500 6X20mg
EUR 257

Dehydrotrametenolic acid

TB0534-0100 20mg
EUR 313

Pachymic Acid

TB0546-0020 25mg
EUR 526

Syringic acid

TB0650 8XX20mg
EUR 274

Succinic acid

TB0657 10X20mg
EUR 274

Oleanonic acid

TB0696-0020 20mg
EUR 207

Echinocystic acid

TB0700 20mg
EUR 186

Betulonic acid

TB0700-0100 20mg
EUR 228

Chicoric acid

TB0709 20mg
EUR 249

Caftaric acid

TB0710 20mg
EUR 420

Quinic acid

TB0713-0020 8XX25mg
EUR 274

Folic acid

TB0797 8XX20mg
EUR 274

Ginkgoneolic acid

TB0798-0025 25mg
EUR 355

Rotundic acid

TB0810-0025 20mg
EUR 271

Gambogic acid

TB0820 20mg
EUR 203

Ellagic acid

TB0845-0100 8XX100mg
EUR 274

Paederosidic acid

TB0859 25mg
EUR 355

Protocatechuic acid

TB0916-0025 10X20mg
EUR 274

Ursoliic Acid

TB253-0020 8XX20mg
EUR 274

Strictosidinic acid

TBP03744 5mg
EUR 1057

Asperulosidic acid

TBW00027 10mg
EUR 355

Terminolic acid

TBW00046 10mg
EUR 461

Firmanoic acid

TBW00079 unit Ask for price

Isomugineic acid

TBW00128 unit Ask for price

Mugineic acid

TBW00129 unit Ask for price

Caffeoylmalic Acid

TBW00209 unit Ask for price

Linolenic acid

TBW00309 3X20mg
EUR 291

Nordihydroguaiaretic acid

TBW00313 20mg
EUR 313

Vanillic acid

TBW00328 10X20mg
EUR 274

Salvianic acid

TBW00423 unit Ask for price

Glucosyringic acid

TBW00429 5mg
EUR 847

Pimaric acid

TBW00488 5mg
EUR 535

Lithocholic acid

TBW00763 5X100mg
EUR 260

Arachidonic acid

TBW00878 20mg Ask for price

Nervonic acid

TBW00879 20mg Ask for price

Fupenzic acid

TBW00889 unit Ask for price

Oleic acid

TBW00897 0.1ml Ask for price

Salicylic acid

TBW00935 25mg Ask for price

Behenic acid

TBW00988 100mg Ask for price

Rupestonic acid

TBW01147 10mg Ask for price

Continentalic acid

TBW01152 10mg Ask for price

Triglochinic acid

TBW01168 20mg Ask for price

Lantanilic acid

TBW01174 unit Ask for price

Isovanillic acid

TBW01215 20mg Ask for price

Glycosmisic acid

TBW01288 2mg Ask for price

Hydroxyvalerenic acid

TBW01291 unit Ask for price

Lauric acid

TBW01299 100mg Ask for price

Arjunic acid

TBW01302 unit Ask for price

Isoferulic acid

TBW01313 unit Ask for price

Hydroxycitric Acid

TBW01328 unit Ask for price

Secologanic acid

TBW01356 5mg Ask for price

Folinic acid

TBW01395 100mg Ask for price

Glycohyodeoxycholic acid

TBW01398 20mg Ask for price

Sericic acid

TBW01434 unit Ask for price

Heynic acid

TBW01435 unit Ask for price

Docosahexaenoic acid

TBW01461 20mg Ask for price

Eicosapentenoic acid

TBW01464 unit Ask for price

Ricinoleic acid

TBW01468 50mg Ask for price

Epigambogic acid

TBW01494 10mg Ask for price

Yohimbic acid

TBW01605 20mg Ask for price

Allocholic Acid

TBW01609 unit Ask for price

Liquiridiolic acid

TBW01637 unit Ask for price

Pyracrenic acid

TBW01747 unit Ask for price

Itaconic acid

TBW01760 5mg Ask for price

Secoxyloganic acid

TBW01779 10mg Ask for price

Anisomelic acid

TBZ0027 unit Ask for price

Anofinic acid

TBZ0037 unit Ask for price

Anziaic acid

TBZ0039 unit Ask for price

Bamuxinic acid

TBZ0077 unit Ask for price

Boninic acid

TBZ0100 unit Ask for price

Bryonolic acid

TBZ0115 unit Ask for price

Camarinic acid

TBZ0130 unit Ask for price

Cryptochlorophaeic acid

TBZ0203 unit Ask for price

Dehydroabietic acid

TBZ0239 20mg Ask for price

Isochlorogenic acid

TBZ0488 unit Ask for price

Isodonoic acid

TBZ0493 unit Ask for price

Linoleic acid

TBZ0552 20mg Ask for price

Manwuweizic acid

TBZ0582 unit Ask for price

Melilotic acid

TBZ0584 unit Ask for price

Neoabietic acid

TBZ0645 unit Ask for price

Nervogenic acid

TBZ0652 unit Ask for price

Paludosic acid

TBZ0705 unit Ask for price

Palustric acid

TBZ0706 unit Ask for price

Perforatic acid

TBZ0715 unit Ask for price

Pisiferic acid

TBZ0741 unit Ask for price

Pomolic acid

TBZ0749 20mg Ask for price

Ramalinolic acid

TBZ0777 unit Ask for price

Sandaracopimaric acid

TBZ0820 unit Ask for price

Phloretic acid

TBZ2357 20mg Ask for price

Agaricic acid

TBZ2381 unit Ask for price

Dihydroartemisinic acid

TBZ2383 20mg Ask for price

Dehydropachymic acid

TBZ2391 10mg Ask for price

Morellic acid

TBZ2392 20mg Ask for price

Gambogenic acid

TBZ2393 20mg Ask for price

Mucic acid

TBZ2413 100mg Ask for price

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