Discovery and characterization of the evolution, variation and functions of diversity-generating retroelements using thousands of genomes and metagenomes.
Diversity-generating retroelements (DGRs) are a novel household of retroelements that generate sequence range of DNA to profit their hosts by introducing variations and accelerating the evolution of goal proteins. They exist extensively in micro organism, archaea, phage and plasmid.
However, our understanding about DGRs in pure environments was nonetheless very restricted.We developed an environment friendly computational algorithm to determine DGRs, and utilized it to characterize DGRs in additional than 80,000 sequenced bacterial genomes in addition to greater than 4,000 human metagenome datasets.
In whole, we recognized 948 non-redundant DGRs, which expanded the quantity of identified DGRs in bacterial genomes and human microbiomes by about 55%, and supplied a way more complete reference for the examine of DGRs. Phylogenetic evaluation was achieved for recognized DGRs.
The putative goal genes of DGRs have been searched, and the functions of these goal genes have been investigated with a complete alignment towards the nr database.DGR system is a robust and common mechanism to generate range. DGR evolution is carefully related to the dwelling atmosphere and their cassette buildings. Furthermore, it might influence a variety of useful processes along with receptor-binding. These outcomes considerably improved our understanding about DGRs.
 Diclofenac |
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| B3505-50 | ApexBio | 50 mg | EUR 128 |
 Diclofenac diethylamine |
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| 20-abx185392 | Abbexa |
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) Diclofenac (diethylamine) |
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| HY-15036A | MedChemExpress | 10mM/1mL | EUR 113 |
) Diclofenac (Sodium) |
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| HY-15037 | MedChemExpress | 5g | EUR 119 |
 Diclofenac [BSA] |
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| DAG3299 | Creative Diagnostics | 1mg | EUR 1105 |
 Diclofenac Sodium |
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| B1457-10 | ApexBio | 10 mg | EUR 108 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-50 | ApexBio | 50 mg | EUR 224 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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Diclofenac Sodium |
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| B1457-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflam |
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 Diclofenac Diethylamine |
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| B1928-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Diethylamine |
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| B1928-50 | ApexBio | 50 mg | EUR 128 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Diethylamine |
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| B1928-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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 Diclofenac Potassium |
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| B1929-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Potassium |
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| B1929-50 | ApexBio | 50 mg | EUR 128 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Potassium |
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| B1929-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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 Diclofenac sodium salt |
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| GP9539-25G | Glentham Life Sciences | 25 g | EUR 86 |
Diclofenac sodium salt |
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| GP9539-5G | Glentham Life Sciences | 5 g | EUR 54 |
 Diclofenac potassium salt |
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| GX9078-1G | Glentham Life Sciences | 1 g | EUR 78 |
Diclofenac potassium salt |
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| GX9078-250MG | Glentham Life Sciences | 250 mg | EUR 58 |
Diclofenac potassium salt |
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| GX9078-5G | Glentham Life Sciences | 5 g | EUR 150 |
 Mouse Anti-Diclofenac monoclonal antibody, clone DC |
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| CABT-L4252-100ug | Creative Diagnostics | 100 ug | EUR 533 |
Mouse Anti-Diclofenac monoclonal antibody, clone DC |
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| CABT-L4252-1mg | Creative Diagnostics | 1 mg | EUR 1313 |
) Octanoic acid (Caorylic acid) |
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| O5678 | Bio Basic | 250ml | EUR 67.4 |
 Okadaic acid, free acid |
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| OL1198 | Bio Basic | 50ug | EUR 192.68 |
) Fumalic acid(Ferulic acid) |
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| E1KS2300 | EnoGene | 50mg | EUR 325 |
) DL-Maleic acid (Toxilic acid) |
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| MA0333 | Bio Basic | 250g | EUR 64.5 |
 D-Glucuronic acid, free acid |
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| GB0482 | Bio Basic | 5g | EUR 155.16 |
 ?-Glycyrrhetinic acid |
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| 9586-1G | Biovision | EUR 120 | |
 Carnosic acid |
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| TB0003 | ChemNorm | 3X20mg | EUR 252 |
 Rosmarinic acid |
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| TB0004 | ChemNorm | 4X20mg | EUR 268 |
 Acetylursolic acid |
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| TB00045 | ChemNorm | 5mg | EUR 739 |
 Benzoic acid |
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| TB00049 | ChemNorm | 8XX50mg | EUR 274 |
 Cichoric Acid |
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| TB0008-0020 | ChemNorm | 20mg | EUR 249 |
 Polygalic acid |
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| TB0011-0100 | ChemNorm | 20mg | EUR 228 |
 Dihydroguaiaretic acid |
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| TB00124 | ChemNorm | 5mg | EUR 697 |
 Polygalacic acid |
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| TB0013 | ChemNorm | 20mg | EUR 262 |
 Chlorogenic acid |
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| TB0022 | ChemNorm | 8XX20mg | EUR 274 |
 Neochlorogenic acid |
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| TB0023 | ChemNorm | 20mg | EUR 203 |
 Cryptochlorogenic acid |
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| TB0024 | ChemNorm | 20mg | EUR 228 |
 Eichlerianic acid |
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| TB00334 | ChemNorm | 5mg | EUR 847 |
 Isocupressic acid |
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| TB00361 | ChemNorm | 5mg | EUR 847 |
 Glycyrrhizic acid |
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| TB0037 | ChemNorm | 4X20mg | EUR 251 |
 Glycyrrhetinic acid |
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| TB0038 | ChemNorm | 10X20mg | EUR 274 |
 Fumaric acid |
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| TB00430 | ChemNorm | 10X100mg | EUR 274 |
 Fumalic acid |
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| TB0050 | ChemNorm | 10X20mg | EUR 274 |
 Euscaphic acid |
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| TB00512 | ChemNorm | 20mg | EUR 612 |
 Acetylisocupressic acid |
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| TB00580 | ChemNorm | 5mg | EUR 911 |
 Esculentic acid |
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| TB00598 | ChemNorm | 5mg | EUR 847 |
 Hardwickiic acid |
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| TB00631 | ChemNorm | 5mg | EUR 847 |
 Decanedioic acid |
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| TB00658 | ChemNorm | 4X100mg | EUR 268 |
 Ceanothic acid |
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| TB00872 | ChemNorm | 5mg | EUR 867 |
 Quinovic acid |
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| TB00888 | ChemNorm | 5mg | EUR 867 |
 Cinnamic Acid |
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| TB0095-1000 | ChemNorm | 10X100mg | EUR 274 |
 Lipoic acid |
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| TB0098 | ChemNorm | 10X20mg | EUR 274 |
 Alphitolic acid |
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| TB01052 | ChemNorm | 5mg | EUR 867 |
 Gallic acid |
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| TB0110 | ChemNorm | 10X50mg | EUR 274 |
 Shikimic acid |
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| TB0112 | ChemNorm | 10X20mg | EUR 274 |
 Confluentic acid |
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| TB01196 | ChemNorm | unit | Ask for price |
 Arjunolic acid |
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| TB01216 | ChemNorm | 5mg | EUR 739 |
 Communic acid |
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| TB01436 | ChemNorm | 5mg | EUR 867 |
 Phytic acid |
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| TB0169 | ChemNorm | 8XX20mg | EUR 274 |
 Cholic acid |
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| TB0171 | ChemNorm | 10X20mg | EUR 274 |
 Hyodeoxycholic acid |
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| TB0172 | ChemNorm | 10X20mg | EUR 274 |
 Deoxycholic acid |
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| TB0173 | ChemNorm | 10X20mg | EUR 274 |
 Moronic acid |
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| TB01734 | ChemNorm | 5mg | EUR 847 |
 Usinic Acid |
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| TB0177-0500 | ChemNorm | 4X25mg | EUR 268 |
 Caffeic Acid |
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| TB0212-0500 | ChemNorm | 10X20mg | EUR 274 |
 Rehmannic acid |
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| TB02271 | ChemNorm | 5mg | EUR 738 |
 Grandiflorenic acid |
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| TB02318 | ChemNorm | 5mg | EUR 738 |
 Oleanolic acid |
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| TB0237-1000 | ChemNorm | 10X20mg | EUR 274 |
 Kaurenoic acid |
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| TB02424 | ChemNorm | 20mg | EUR 249 |
 Isopimaric acid |
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| TB02501 | ChemNorm | 5mg | EUR 763 |
 Hydrocinnamic acid |
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| TB02940 | ChemNorm | unit | Ask for price |
 Asiatic acid |
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| TB0298-0200 | ChemNorm | 4X20mg | EUR 268 |
 Palmitic acid |
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| TB0314-0020 | ChemNorm | 6X20mg | EUR 257 |
 Loganic acid |
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| TB0330-0020 | ChemNorm | 3X20mg | EUR 291 |
 Betulinic Acid |
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| TB0348-0020 | ChemNorm | 8XX20mg | EUR 274 |
 Corosolic Acid |
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| TB0356-0020 | ChemNorm | 20mg | EUR 228 |
 Geniposidic Acid |
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| TB0376-1000 | ChemNorm | 5X20mg | EUR 274 |
 Roburic Acid |
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| TB0383-0020 | ChemNorm | 20mg | EUR 249 |
 Homovanillic acid |
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| TB0459 | ChemNorm | 4X20mg | EUR 268 |
 Lithospermic Acid |
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| TB0459-0020 | ChemNorm | 25mg | EUR 271 |
 Isoferulic acid |
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| TB0485-0500 | ChemNorm | 6X20mg | EUR 257 |
 Dehydrotrametenolic acid |
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| TB0534-0100 | ChemNorm | 20mg | EUR 313 |
 Pachymic Acid |
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| TB0546-0020 | ChemNorm | 25mg | EUR 526 |
 Syringic acid |
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| TB0650 | ChemNorm | 8XX20mg | EUR 274 |
 Succinic acid |
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| TB0657 | ChemNorm | 10X20mg | EUR 274 |
 Oleanonic acid |
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| TB0696-0020 | ChemNorm | 20mg | EUR 207 |
 Echinocystic acid |
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| TB0700 | ChemNorm | 20mg | EUR 186 |
 Betulonic acid |
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| TB0700-0100 | ChemNorm | 20mg | EUR 228 |
 Chicoric acid |
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| TB0709 | ChemNorm | 20mg | EUR 249 |
 Caftaric acid |
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| TB0710 | ChemNorm | 20mg | EUR 420 |
 Quinic acid |
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| TB0713-0020 | ChemNorm | 8XX25mg | EUR 274 |
 Folic acid |
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| TB0797 | ChemNorm | 8XX20mg | EUR 274 |
 Ginkgoneolic acid |
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| TB0798-0025 | ChemNorm | 25mg | EUR 355 |
 Rotundic acid |
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| TB0810-0025 | ChemNorm | 20mg | EUR 271 |
 Gambogic acid |
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| TB0820 | ChemNorm | 20mg | EUR 203 |
 Ellagic acid |
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| TB0845-0100 | ChemNorm | 8XX100mg | EUR 274 |
 Paederosidic acid |
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| TB0859 | ChemNorm | 25mg | EUR 355 |
 Protocatechuic acid |
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| TB0916-0025 | ChemNorm | 10X20mg | EUR 274 |
 Ursoliic Acid |
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| TB253-0020 | ChemNorm | 8XX20mg | EUR 274 |
 Strictosidinic acid |
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| TBP03744 | ChemNorm | 5mg | EUR 1057 |
 Asperulosidic acid |
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| TBW00027 | ChemNorm | 10mg | EUR 355 |
 Terminolic acid |
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| TBW00046 | ChemNorm | 10mg | EUR 461 |
 Firmanoic acid |
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| TBW00079 | ChemNorm | unit | Ask for price |
 Isomugineic acid |
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| TBW00128 | ChemNorm | unit | Ask for price |
 Mugineic acid |
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| TBW00129 | ChemNorm | unit | Ask for price |
 Caffeoylmalic Acid |
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| TBW00209 | ChemNorm | unit | Ask for price |
 Linolenic acid |
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| TBW00309 | ChemNorm | 3X20mg | EUR 291 |
 Nordihydroguaiaretic acid |
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| TBW00313 | ChemNorm | 20mg | EUR 313 |
 Vanillic acid |
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| TBW00328 | ChemNorm | 10X20mg | EUR 274 |
 Salvianic acid |
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| TBW00423 | ChemNorm | unit | Ask for price |
 Glucosyringic acid |
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| TBW00429 | ChemNorm | 5mg | EUR 847 |
 Pimaric acid |
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| TBW00488 | ChemNorm | 5mg | EUR 535 |
 Lithocholic acid |
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| TBW00763 | ChemNorm | 5X100mg | EUR 260 |
 Arachidonic acid |
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| TBW00878 | ChemNorm | 20mg | Ask for price |
 Nervonic acid |
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| TBW00879 | ChemNorm | 20mg | Ask for price |
 Fupenzic acid |
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| TBW00889 | ChemNorm | unit | Ask for price |
 Oleic acid |
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| TBW00897 | ChemNorm | 0.1ml | Ask for price |
 Salicylic acid |
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| TBW00935 | ChemNorm | 25mg | Ask for price |
 Behenic acid |
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| TBW00988 | ChemNorm | 100mg | Ask for price |
 Rupestonic acid |
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| TBW01147 | ChemNorm | 10mg | Ask for price |
 Continentalic acid |
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| TBW01152 | ChemNorm | 10mg | Ask for price |
 Triglochinic acid |
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| TBW01168 | ChemNorm | 20mg | Ask for price |
 Lantanilic acid |
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| TBW01174 | ChemNorm | unit | Ask for price |
 Isovanillic acid |
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| TBW01215 | ChemNorm | 20mg | Ask for price |
 Glycosmisic acid |
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| TBW01288 | ChemNorm | 2mg | Ask for price |
 Hydroxyvalerenic acid |
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| TBW01291 | ChemNorm | unit | Ask for price |
 Lauric acid |
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| TBW01299 | ChemNorm | 100mg | Ask for price |
 Arjunic acid |
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| TBW01302 | ChemNorm | unit | Ask for price |
Isoferulic acid |
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| TBW01313 | ChemNorm | unit | Ask for price |
 Hydroxycitric Acid |
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| TBW01328 | ChemNorm | unit | Ask for price |
 Secologanic acid |
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| TBW01356 | ChemNorm | 5mg | Ask for price |
 Folinic acid |
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| TBW01395 | ChemNorm | 100mg | Ask for price |
 Glycohyodeoxycholic acid |
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| TBW01398 | ChemNorm | 20mg | Ask for price |
 Sericic acid |
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| TBW01434 | ChemNorm | unit | Ask for price |
 Heynic acid |
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| TBW01435 | ChemNorm | unit | Ask for price |
 Docosahexaenoic acid |
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| TBW01461 | ChemNorm | 20mg | Ask for price |
 Eicosapentenoic acid |
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| TBW01464 | ChemNorm | unit | Ask for price |
 Ricinoleic acid |
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| TBW01468 | ChemNorm | 50mg | Ask for price |
 Epigambogic acid |
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| TBW01494 | ChemNorm | 10mg | Ask for price |
 Yohimbic acid |
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| TBW01605 | ChemNorm | 20mg | Ask for price |
 Allocholic Acid |
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| TBW01609 | ChemNorm | unit | Ask for price |
 Liquiridiolic acid |
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| TBW01637 | ChemNorm | unit | Ask for price |
 Pyracrenic acid |
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| TBW01747 | ChemNorm | unit | Ask for price |
 Itaconic acid |
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| TBW01760 | ChemNorm | 5mg | Ask for price |
 Secoxyloganic acid |
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| TBW01779 | ChemNorm | 10mg | Ask for price |
 Anisomelic acid |
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| TBZ0027 | ChemNorm | unit | Ask for price |
 Anofinic acid |
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| TBZ0037 | ChemNorm | unit | Ask for price |
 Anziaic acid |
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| TBZ0039 | ChemNorm | unit | Ask for price |
 Bamuxinic acid |
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| TBZ0077 | ChemNorm | unit | Ask for price |
 Boninic acid |
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| TBZ0100 | ChemNorm | unit | Ask for price |
 Bryonolic acid |
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| TBZ0115 | ChemNorm | unit | Ask for price |
 Camarinic acid |
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| TBZ0130 | ChemNorm | unit | Ask for price |
 Cryptochlorophaeic acid |
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| TBZ0203 | ChemNorm | unit | Ask for price |
 Dehydroabietic acid |
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| TBZ0239 | ChemNorm | 20mg | Ask for price |
 Isochlorogenic acid |
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| TBZ0488 | ChemNorm | unit | Ask for price |
 Isodonoic acid |
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| TBZ0493 | ChemNorm | unit | Ask for price |
 Linoleic acid |
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| TBZ0552 | ChemNorm | 20mg | Ask for price |
 Manwuweizic acid |
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| TBZ0582 | ChemNorm | unit | Ask for price |
 Melilotic acid |
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| TBZ0584 | ChemNorm | unit | Ask for price |
 Neoabietic acid |
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| TBZ0645 | ChemNorm | unit | Ask for price |
 Nervogenic acid |
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| TBZ0652 | ChemNorm | unit | Ask for price |
 Paludosic acid |
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| TBZ0705 | ChemNorm | unit | Ask for price |
 Palustric acid |
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| TBZ0706 | ChemNorm | unit | Ask for price |
 Perforatic acid |
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| TBZ0715 | ChemNorm | unit | Ask for price |
 Pisiferic acid |
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| TBZ0741 | ChemNorm | unit | Ask for price |
 Pomolic acid |
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| TBZ0749 | ChemNorm | 20mg | Ask for price |
 Ramalinolic acid |
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| TBZ0777 | ChemNorm | unit | Ask for price |
 Sandaracopimaric acid |
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| TBZ0820 | ChemNorm | unit | Ask for price |
 Phloretic acid |
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| TBZ2357 | ChemNorm | 20mg | Ask for price |
 Agaricic acid |
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| TBZ2381 | ChemNorm | unit | Ask for price |
 Dihydroartemisinic acid |
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| TBZ2383 | ChemNorm | 20mg | Ask for price |
 Dehydropachymic acid |
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| TBZ2391 | ChemNorm | 10mg | Ask for price |
 Morellic acid |
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| TBZ2392 | ChemNorm | 20mg | Ask for price |
 Gambogenic acid |
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| TBZ2393 | ChemNorm | 20mg | Ask for price |
 Mucic acid |
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| TBZ2413 | ChemNorm | 100mg | Ask for price |